ETA receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HCQ

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

March 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

87 interactions (Click to see)

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-3, endothelin-2, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 W 190 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 W 190 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 W 190 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 V 193 - G.H5 M 351 G.H5.18
Van-der-waals ICL2 V 193 - G.H5 M 351 G.H5.18
Polar C-term S 373 - G.H5 L 358 G.H5.25
Hydrophobic C-term S 373 - G.H5 L 358 G.H5.25
Hydrophobic C-term F 376 - G.H5 N 357 G.H5.24
Van-der-waals C-term F 376 - G.H5 N 357 G.H5.24
Polar TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Van-der-waals TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 W 190 - G.S2 V 192 G.S2.04
Van-der-waals ICL2 W 190 - G.S2 V 192 G.S2.04
Polar ICL2 R 192 - G.H5 N 352 G.H5.19
Hydrophobic ICL2 V 193 - G.H5 I 348 G.H5.15
Ionic TM6 R 301 6x30 G.H5 D 346 G.H5.13
Polar C-term S 373 - G.H5 N 357 G.H5.24
Hydrophobic C-term S 373 - G.H5 N 357 G.H5.24
Van-der-waals C-term S 373 - G.H5 N 357 G.H5.24
Hydrophobic TM3 A 186 3x53 G.H5 N 352 G.H5.19
Van-der-waals C-term K 375 - G.H5 N 357 G.H5.24
Hydrophobic TM3 R 183 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM7 V 372 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM2 P 115 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 115 2x39 G.H5 Y 356 G.H5.23
Polar TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 W 190 - G.HN L 34 G.HN.52
Hydrophobic TM3 V 187 3x54 G.H5 L 349 G.H5.16
Aromatic TM3 R 183 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 183 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 V 304 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM6 R 301 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 301 6x30 G.H5 L 349 G.H5.16
Hydrophobic TM6 H 297 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 H 297 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 V 304 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 304 6x33 G.H5 L 358 G.H5.25
Ionic TM6 H 297 6x26 G.H5 D 346 G.H5.13
Polar TM6 H 297 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM6 H 297 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 H 297 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM7 V 372 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 L 369 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 369 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM6 V 308 6x37 G.H5 L 358 G.H5.25
Polar TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 W 190 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 W 190 - G.H5 I 348 G.H5.15
Hydrophobic TM5 M 282 5x65 G.H5 L 349 G.H5.16