S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VIF

RESOLUTION

2.8 Å

REFERENCE

10.1073/PNAS.2117716119

PUBLICATION DATE

Sept. 28, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

(S)-FTY720-phosphate - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

sphingosylphosphorylcholine, sphingosine 1-phosphate, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 250 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Ionic TM6 K 250 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 250 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 250 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 353 G.H5.25
Polar H8 N 315 8x47 G.H5 F 354 G.H5.26
Polar H8 K 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 316 8x48 G.H5 F 354 G.H5.26
Polar H8 N 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Polar ICL2 M 149 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 149 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 149 - G.H5 N 347 G.H5.19
Polar ICL2 H 152 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 152 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 L 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 F 237 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 L 235 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 235 - G.H5 D 337 G.H5.09
Polar ICL3 T 236 - G.H5 D 337 G.H5.09
Polar TM3 T 145 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 149 - G.H5 I 344 G.H5.16
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 150 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 150 - G.H5 I 343 G.H5.15
Polar ICL2 N 153 - G.H5 N 347 G.H5.19
Ionic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Polar TM6 K 250 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 250 6x29 G.H5 D 341 G.H5.13
Aromatic ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 237 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 151 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 254 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 151 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 L 151 - G.S1 E 33 G.S1.01
Hydrophobic TM6 K 250 6x29 G.H5 L 348 G.H5.20
Polar TM2 R 78 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 M 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 146 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 F 237 - G.H5 D 341 G.H5.13
Hydrophobic TM2 M 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 T 145 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 T 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 151 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 151 - G.S1 V 34 G.S1.02
Hydrophobic TM6 K 250 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 250 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 M 149 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 F 237 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 F 237 - G.H5 D 337 G.H5.09
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 C 351 G.H5.23
Ionic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 78 2x37 G.H5 D 350 G.H5.22
Polar ICL2 N 153 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 153 - G.H5 D 350 G.H5.22