H4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 R 123 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 123 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL4 H 362 - G.H5 D 350 G.H5.22
Van-der-waals ICL4 H 362 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 293 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL4 C 361 - G.H5 C 351 G.H5.23
Van-der-waals ICL4 C 361 - G.H5 C 351 G.H5.23
Ionic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 204 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 301 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 301 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL4 H 362 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 293 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 H 126 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 126 - G.hns1 R 32 G.hns1.03
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL4 K 363 - G.H5 G 352 G.H5.24
Ionic H8 R 364 8x49 G.H5 D 350 G.H5.22
Polar H8 R 364 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 364 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 364 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 197 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 304 6x36 G.H5 L 353 G.H5.25
Polar ICL4 C 361 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 C 361 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 C 361 - G.H5 G 352 G.H5.24
Hydrophobic TM5 R 204 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 204 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Polar TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Polar ICL2 T 124 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 348 G.H5.20
Ionic ICL2 H 126 - G.HN E 28 G.HN.52
Hydrophobic ICL2 H 126 - G.HN E 28 G.HN.52
Van-der-waals ICL4 K 363 - G.H5 K 349 G.H5.21
Hydrophobic TM5 L 201 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 201 5x65 G.H5 F 354 G.H5.26
Polar ICL4 K 363 - G.H5 D 350 G.H5.22
Van-der-waals ICL4 K 363 - G.H5 D 350 G.H5.22
Hydrophobic TM6 K 300 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 300 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 297 6x29 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 297 6x29 G.h4s6 K 314 G.h4s6.08