Refined structure (7W40) of Gq - BB2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 283 from structure (78.8%), 76 from model (21.2%)
Residue sidechains - 265 from structure (73.8%), 94 from model (26.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 Structure Structure
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure Structure
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure Structure
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure Structure
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure Structure
G.s1h1 48 G G.s1h1.03 Structure Structure
G.s1h1 49 E G.s1h1.04 Structure Structure
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure Structure
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 Structure Structure
G.H1 63 H G.H1.12 Structure Structure
G.h1ha 64 G G.h1ha.01 Structure Structure
G.h1ha 65 S G.h1ha.02 Structure Structure
G.h1ha 66 G G.h1ha.03 Structure Structure
G.h1ha 67 Y G.h1ha.04 Structure Structure
G.h1ha 68 S G.h1ha.05 Structure Structure
H.HA 69 D H.HA.01 Structure Structure
H.HA 70 E H.HA.02 Structure Structure
H.HA 71 D H.HA.03 Structure Structure
H.HA 72 K H.HA.04 Structure Structure
H.HA 73 R H.HA.05 Structure Structure
H.HA 74 G H.HA.06 Structure Structure
H.HA 75 F H.HA.07 Structure Structure
H.HA 76 T H.HA.08 Structure Structure
H.HA 77 K H.HA.09 Structure Structure
H.HA 78 L H.HA.10 Structure Structure
H.HA 79 V H.HA.11 Structure Structure
H.HA 80 Y H.HA.12 Structure Structure
H.HA 81 Q H.HA.13 Structure Structure
H.HA 82 N H.HA.14 Structure Structure
H.HA 83 I H.HA.15 Structure Structure
H.HA 84 F H.HA.16 Structure Structure
H.HA 85 T H.HA.17 Structure Structure
H.HA 86 A H.HA.18 Structure Structure
H.HA 87 M H.HA.19 Structure Structure
H.HA 88 Q H.HA.20 Structure Structure
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 Structure Structure
H.HD 147 R H.HD.09 Structure Structure
H.HD 148 R H.HD.10 Structure Structure
H.HD 149 R H.HD.11 Structure Structure
H.HD 150 E H.HD.12 Structure Structure
H.hdhe 151 Y H.hdhe.01 Structure Structure
H.hdhe 152 Q H.hdhe.02 Structure Structure
H.hdhe 153 L H.hdhe.03 Structure Structure
H.hdhe 154 S H.hdhe.04 Structure Structure
H.hdhe 155 D H.hdhe.05 Structure Structure
H.HE 156 S H.HE.01 Structure Structure
H.HE 157 T H.HE.02 Structure Structure
H.HE 158 K H.HE.03 Structure Structure
H.HE 159 Y H.HE.04 Structure Structure
H.HE 160 Y H.HE.05 Structure Structure
H.HE 161 L H.HE.06 Structure Structure
H.HE 162 N H.HE.07 Structure Structure
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 Structure Structure
H.hehf 175 T H.hehf.07 Structure Structure
H.HF 176 Q H.HF.01 Structure Structure
H.HF 177 Q H.HF.02 Structure Structure
H.HF 178 D H.HF.03 Structure Structure
H.HF 179 V H.HF.04 Structure Structure
H.HF 180 L H.HF.05 Structure Structure
H.HF 181 R H.HF.06 Structure Structure
G.hfs2 182 V G.hfs2.01 Structure Structure
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure Structure
G.hfs2 185 P G.hfs2.04 Structure Structure
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure Structure
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure Structure
G.S2 193 P G.S2.05 Structure Structure
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure Structure
G.S2 196 L G.S2.08 Structure Structure
G.s2s3 197 Q G.s2s3.01 Structure Structure
G.s2s3 198 S G.s2s3.02 Structure Structure
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure Structure
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure Structure
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure Structure
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure Structure
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure Structure
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure Structure
G.h2s4 222 N G.h2s4.03 Structure Structure
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure Structure
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure Structure
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure Structure
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure Structure
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure Structure
G.s4h3 237 Q G.s4h3.06 Structure Structure
G.s4h3 238 V G.s4h3.07 Structure Structure
G.s4h3 239 L G.s4h3.08 Structure Structure
G.s4h3 240 V G.s4h3.09 Structure Structure
G.s4h3 241 E G.s4h3.10 Structure Structure
G.s4h3 242 S G.s4h3.11 Structure Structure
G.s4h3 243 D G.s4h3.12 Structure Structure
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure Structure
G.s4h3 246 N G.s4h3.15 Structure Structure
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure Structure
G.H3 249 E G.H3.03 Structure Structure
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure Structure
G.H3 253 A G.H3.07 Structure Structure
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure Structure
G.H3 257 T G.H3.11 Structure Structure
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure Structure
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure Structure
G.H3 262 P G.H3.16 Structure Structure
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure Structure
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure Structure
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure Structure
G.HG 284 M G.HG.09 Structure Structure
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure Structure
G.HG 288 L G.HG.15 Structure Structure
G.HG 289 V G.HG.16 Structure Structure
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure Structure
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure Structure
G.hgh4 298 P G.hgh4.08 Structure Structure
G.H4 299 Q G.H4.01 Structure Structure
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure Structure
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure Structure
G.H4 304 A G.H4.06 Structure Structure
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure Structure
G.H4 307 E G.H4.09 Structure Structure
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure Structure
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 Structure Structure
G.h4s6 318 P G.h4s6.09 Structure Structure
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure Structure
G.h4s6 322 K G.h4s6.13 Structure Structure
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure Structure
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure Structure
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 301 from structure (86.2%), 48 from model (13.8%)
Residue sidechains - 266 from structure (76.2%), 83 from model (23.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 C - AF2 AF2
N-term 7 F - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 D - AF2 AF2
N-term 15 H - AF2 AF2
N-term 16 F - AF2 AF2
N-term 17 M - AF2 AF2
N-term 18 H - AF2 AF2
N-term 19 C - AF2 AF2
N-term 20 N - AF2 AF2
N-term 21 I - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 H - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 L - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 V - AF2 AF2
N-term 31 N - AF2 AF2
N-term 32 D - AF2 AF2
N-term 33 D - AF2 AF2
N-term 34 W - AF2 AF2
N-term 35 S - AF2 AF2
N-term 36 H - AF2 AF2
TM1 37 P 1.29x29 Structure Structure
TM1 38 G 1.30x30 Structure Structure
TM1 39 I 1.31x31 Structure AF2
TM1 40 L 1.32x32 Structure AF2
TM1 41 Y 1.33x33 Structure AF2
TM1 42 V 1.34x34 Structure AF2
TM1 43 I 1.35x35 Structure AF2
TM1 44 P 1.36x36 Structure Structure
TM1 45 A 1.37x37 Structure Structure
TM1 46 V 1.38x38 Structure AF2
TM1 47 Y 1.39x39 Structure Structure
TM1 48 G 1.40x40 Structure Structure
TM1 49 V 1.41x41 Structure AF2
TM1 50 I 1.42x42 Structure AF2
TM1 51 I 1.43x43 Structure AF2
TM1 52 L 1.44x44 Structure AF2
TM1 53 I 1.45x45 Structure AF2
TM1 54 G 1.46x46 Structure Structure
TM1 55 L 1.47x47 Structure AF2
TM1 56 I 1.48x48 Structure AF2
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 I 1.51x51 Structure Structure
TM1 60 T 1.52x52 Structure Structure
TM1 61 L 1.53x53 Structure Structure
TM1 62 I 1.54x54 Structure AF2
TM1 63 K 1.55x55 Structure AF2
TM1 64 I 1.56x56 Structure AF2
TM1 65 F 1.57x57 Structure Structure
TM1 66 C 1.58x58 Structure Structure
TM1 67 T 1.59x59 Structure AF2
TM1 68 V 1.60x60 Structure AF2
ICL1 69 K 12.48x48 Structure AF2
ICL1 70 S 12.49x49 Structure Structure
ICL1 71 M 12.50x50 Structure Structure
ICL1 72 R 12.51x51 Structure Structure
TM2 73 N 2.37x37 Structure Structure
TM2 74 V 2.38x38 Structure Structure
TM2 75 P 2.39x39 Structure Structure
TM2 76 N 2.40x40 Structure Structure
TM2 77 L 2.41x41 Structure Structure
TM2 78 F 2.42x42 Structure Structure
TM2 79 I 2.43x43 Structure Structure
TM2 80 S 2.44x44 Structure Structure
TM2 81 S 2.45x45 Structure Structure
TM2 82 L 2.46x46 Structure Structure
TM2 83 A 2.47x47 Structure Structure
TM2 84 L 2.48x48 Structure Structure
TM2 85 G 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure AF2
TM2 87 L 2.51x51 Structure AF2
TM2 88 L 2.52x52 Structure Structure
TM2 89 L 2.53x53 Structure Structure
TM2 90 L 2.54x54 Structure AF2
TM2 91 I 2.55x55 Structure Structure
TM2 92 T 2.56x551 Structure Structure
TM2 93 C 2.57x56 Structure Structure
TM2 94 A 2.58x57 Structure Structure
TM2 95 P 2.59x58 Structure Structure
TM2 96 V 2.60x59 Structure Structure
TM2 97 D 2.61x60 Structure Structure
TM2 98 A 2.62x61 Structure Structure
TM2 99 S 2.63x62 Structure Structure
TM2 100 R 2.64x63 Structure Structure
TM2 101 Y 2.65x64 Structure Structure
TM2 102 L 2.66x65 Structure Structure
TM2 103 A 2.67x66 Structure Structure
ECL1 104 D - Structure Structure
ECL1 105 R 23.49x49 Structure Structure
ECL1 106 W 23.50x50 Structure Structure
ECL1 107 L 23.51x51 Structure Structure
ECL1 108 F 23.52x52 Structure Structure
TM3 109 G 3.21x21 Structure Structure
TM3 110 R 3.22x22 Structure Structure
TM3 111 I 3.23x23 Structure Structure
TM3 112 G 3.24x24 Structure Structure
TM3 113 C 3.25x25 Structure Structure
TM3 114 K 3.26x26 Structure Structure
TM3 115 L 3.27x27 Structure Structure
TM3 116 I 3.28x28 Structure Structure
TM3 117 P 3.29x29 Structure Structure
TM3 118 F 3.30x30 Structure Structure
TM3 119 I 3.31x31 Structure Structure
TM3 120 Q 3.32x32 Structure Structure
TM3 121 L 3.33x33 Structure Structure
TM3 122 T 3.34x34 Structure Structure
TM3 123 S 3.35x35 Structure Structure
TM3 124 V 3.36x36 Structure Structure
TM3 125 G 3.37x37 Structure Structure
TM3 126 V 3.38x38 Structure Structure
TM3 127 S 3.39x39 Structure Structure
TM3 128 V 3.40x40 Structure Structure
TM3 129 F 3.41x41 Structure Structure
TM3 130 T 3.42x42 Structure Structure
TM3 131 L 3.43x43 Structure Structure
TM3 132 T 3.44x44 Structure Structure
TM3 133 A 3.45x45 Structure Structure
TM3 134 L 3.46x46 Structure Structure
TM3 135 S 3.47x47 Structure Structure
TM3 136 A 3.48x48 Structure Structure
TM3 137 D 3.49x49 Structure Structure
TM3 138 R 3.50x50 Structure Structure
TM3 139 Y 3.51x51 Structure Structure
TM3 140 K 3.52x52 Structure Structure
TM3 141 A 3.53x53 Structure Structure
TM3 142 I 3.54x54 Structure Structure
TM3 143 V 3.55x55 Structure Structure
TM3 144 R 3.56x56 Structure Structure
ICL2 145 P 34.50x50 Structure Structure
ICL2 146 M 34.51x51 Structure Structure
ICL2 147 D 34.52x52 Structure Structure
ICL2 148 I 34.53x53 Structure AF2
ICL2 149 Q 34.54x54 Structure AF2
ICL2 150 A 34.55x55 Structure Structure
ICL2 151 S 34.56x56 Structure Structure
ICL2 152 H 34.57x57 Structure AF2
TM4 153 A 4.38x38 Structure Structure
TM4 154 L 4.39x39 Structure Structure
TM4 155 M 4.40x40 Structure Structure
TM4 156 K 4.41x41 Structure Structure
TM4 157 I 4.42x42 Structure AF2
TM4 158 C 4.43x43 Structure Structure
TM4 159 L 4.44x44 Structure Structure
TM4 160 K 4.45x45 Structure Structure
TM4 161 A 4.46x46 Structure Structure
TM4 162 A 4.47x47 Structure Structure
TM4 163 F 4.48x48 Structure Structure
TM4 164 I 4.49x49 Structure Structure
TM4 165 W 4.50x50 Structure Structure
TM4 166 I 4.51x51 Structure Structure
TM4 167 I 4.52x52 Structure Structure
TM4 168 S 4.53x53 Structure Structure
TM4 169 M 4.54x54 Structure Structure
TM4 170 L 4.55x55 Structure Structure
TM4 171 L 4.56x56 Structure Structure
TM4 172 A 4.57x57 Structure Structure
TM4 173 I 4.58x59 Structure Structure
TM4 174 P 4.59x60 Structure Structure
TM4 175 E 4.60x61 Structure AF2
TM4 176 A 4.61x62 Structure Structure
TM4 177 V 4.62x63 Structure Structure
TM4 178 F 4.63x64 Structure Structure
TM4 179 S 4.64x65 Structure Structure
ECL2 180 D - Structure Structure
ECL2 181 L - Structure Structure
ECL2 182 H - Structure Structure
ECL2 183 P - Structure Structure
ECL2 184 F - Structure Structure
ECL2 185 H - Structure AF2
ECL2 186 E - Structure AF2
ECL2 187 E - Structure AF2
ECL2 188 S - Structure Structure
ECL2 189 T - Structure AF2
ECL2 190 N - Structure AF2
ECL2 191 Q - Structure AF2
ECL2 192 T - Structure Structure
ECL2 193 F - Structure Structure
ECL2 194 I - Structure Structure
ECL2 195 S - Structure Structure
ECL2 196 C 45.50x50 Structure Structure
ECL2 197 A 45.51x51 Structure Structure
ECL2 198 P 45.52x52 Structure Structure
ECL2 199 Y - Structure Structure
ECL2 200 P - Structure Structure
ECL2 201 H - Structure Structure
ECL2 202 S - Structure Structure
TM5 203 N 5.31x32 Structure Structure
TM5 204 E 5.32x33 Structure Structure
TM5 205 L 5.33x34 Structure Structure
TM5 206 H 5.34x35 Structure Structure
TM5 207 P 5.35x36 Structure Structure
TM5 208 K 5.36x37 Structure Structure
TM5 209 I 5.37x38 Structure Structure
TM5 210 H 5.38x39 Structure Structure
TM5 211 S 5.39x40 Structure Structure
TM5 212 M 5.40x41 Structure Structure
TM5 213 A 5.41x42 Structure Structure
TM5 214 S 5.42x43 Structure Structure
TM5 215 F 5.43x44 Structure Structure
TM5 216 L 5.44x45 Structure Structure
TM5 217 V 5.45x46 Structure Structure
TM5 218 F 5.46x461 Structure Structure
TM5 219 Y 5.47x47 Structure Structure
TM5 220 V 5.48x48 Structure Structure
TM5 221 I 5.49x49 Structure Structure
TM5 222 P 5.50x50 Structure Structure
TM5 223 L 5.51x51 Structure Structure
TM5 224 S 5.52x52 Structure Structure
TM5 225 I 5.53x53 Structure Structure
TM5 226 I 5.54x54 Structure Structure
TM5 227 S 5.55x55 Structure Structure
TM5 228 V 5.56x56 Structure Structure
TM5 229 Y 5.57x57 Structure Structure
TM5 230 Y 5.58x58 Structure Structure
TM5 231 Y 5.59x59 Structure Structure
TM5 232 F 5.60x60 Structure Structure
TM5 233 I 5.61x61 Structure Structure
TM5 234 A 5.62x62 Structure Structure
TM5 235 K 5.63x63 Structure Structure
TM5 236 N 5.64x64 Structure Structure
TM5 237 L 5.65x65 Structure Structure
TM5 238 I 5.66x66 Structure Structure
TM5 239 Q 5.67x67 Structure Structure
TM5 240 S 5.68x68 Structure Structure
TM5 241 A 5.69x69 Structure Structure
TM5 242 Y 5.70x70 Structure Structure
TM5 243 N 5.71x71 Structure Structure
TM5 244 L 5.72x72 Structure Structure
ICL3 245 P - Structure Structure
ICL3 246 V - Structure Structure
ICL3 247 E - Structure Structure
ICL3 248 G - Structure Structure
TM6 249 N 6.20x20 Structure Structure
TM6 250 I 6.21x21 Structure Structure
TM6 251 H 6.22x22 Structure Structure
TM6 252 V 6.23x23 Structure Structure
TM6 253 K 6.24x24 Structure Structure
TM6 254 K 6.25x25 Structure Structure
TM6 255 Q 6.26x26 Structure Structure
TM6 256 I 6.27x27 Structure Structure
TM6 257 E 6.28x28 Structure Structure
TM6 258 S 6.29x29 Structure Structure
TM6 259 R 6.30x30 Structure Structure
TM6 260 K 6.31x31 Structure Structure
TM6 261 R 6.32x32 Structure Structure
TM6 262 L 6.33x33 Structure Structure
TM6 263 A 6.34x34 Structure Structure
TM6 264 K 6.35x35 Structure Structure
TM6 265 T 6.36x36 Structure Structure
TM6 266 V 6.37x37 Structure Structure
TM6 267 L 6.38x38 Structure Structure
TM6 268 V 6.39x39 Structure Structure
TM6 269 F 6.40x40 Structure Structure
TM6 270 V 6.41x41 Structure Structure
TM6 271 G 6.42x42 Structure Structure
TM6 272 L 6.43x43 Structure Structure
TM6 273 F 6.44x44 Structure Structure
TM6 274 A 6.45x45 Structure Structure
TM6 275 F 6.46x46 Structure Structure
TM6 276 C 6.47x47 Structure Structure
TM6 277 W 6.48x48 Structure Structure
TM6 278 L 6.49x49 Structure Structure
TM6 279 P 6.50x50 Structure Structure
TM6 280 N 6.51x51 Structure Structure
TM6 281 H 6.52x52 Structure Structure
TM6 282 V 6.53x53 Structure Structure
TM6 283 I 6.54x54 Structure Structure
TM6 284 Y 6.55x55 Structure Structure
TM6 285 L 6.56x56 Structure Structure
TM6 286 Y 6.57x57 Structure Structure
TM6 287 R 6.58x58 Structure Structure
TM6 288 S 6.59x59 Structure Structure
TM6 289 Y 6.60x60 Structure Structure
TM6 290 H 6.61x61 Structure Structure
ECL3 291 Y - Structure Structure
ECL3 292 S - Structure Structure
ECL3 293 E - Structure AF2
ECL3 294 V - Structure Structure
ECL3 295 D - Structure Structure
ECL3 296 T - Structure Structure
TM7 297 S 7.28x27 Structure Structure
TM7 298 M 7.29x28 Structure Structure
TM7 299 L 7.30x29 Structure Structure
TM7 300 H 7.31x30 Structure Structure
TM7 301 F 7.32x31 Structure Structure
TM7 302 V 7.33x32 Structure Structure
TM7 303 T 7.34x33 Structure Structure
TM7 304 S 7.35x34 Structure Structure
TM7 305 I 7.36x35 Structure Structure
TM7 306 C 7.37x36 Structure Structure
TM7 307 A 7.38x37 Structure Structure
TM7 308 R 7.39x38 Structure Structure
TM7 309 L 7.40x39 Structure Structure
TM7 310 L 7.41x40 Structure Structure
TM7 311 A 7.42x41 Structure Structure
TM7 312 F 7.43x42 Structure Structure
TM7 313 T 7.44x43 Structure Structure
TM7 314 N 7.45x45 Structure Structure
TM7 315 S 7.46x46 Structure Structure
TM7 316 C 7.47x47 Structure Structure
TM7 317 V 7.48x48 Structure Structure
TM7 318 N 7.49x49 Structure Structure
TM7 319 P 7.50x50 Structure Structure
TM7 320 F 7.51x51 Structure Structure
TM7 321 A 7.52x52 Structure Structure
TM7 322 L 7.53x53 Structure Structure
TM7 323 Y 7.54x54 Structure Structure
TM7 324 L 7.55x55 Structure Structure
TM7 325 L 7.56x56 Structure Structure
H8 326 S 8.47x47 Structure Structure
H8 327 K 8.48x48 Structure AF2
H8 328 S 8.49x49 Structure Structure
H8 329 F 8.50x50 Structure Structure
H8 330 R 8.51x51 Structure Structure
H8 331 K 8.52x52 Structure Structure
H8 332 Q 8.53x53 Structure Structure
H8 333 F 8.54x54 Structure Structure
H8 334 N 8.55x55 Structure Structure
H8 335 T 8.56x56 Structure Structure
H8 336 Q 8.57x57 Structure Structure
H8 337 L 8.58x58 Structure Structure
H8 338 L 8.59x59 AF2 AF2
H8 339 C 8.60x60 AF2 AF2
C-term 340 C - AF2 AF2
C-term 341 Q - AF2 AF2
C-term 342 P - AF2 AF2
C-term 343 G - AF2 AF2
C-term 344 L - AF2 AF2
C-term 345 I - AF2 AF2
C-term 346 I - AF2 AF2
C-term 347 R - AF2 AF2
C-term 348 S - AF2 AF2
C-term 349 H - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 H 251 6x22 G.H4 L 310 G.H4.12
Van-der-waals TM6 H 251 6x22 G.H4 L 310 G.H4.12
Hydrophobic TM6 V 252 6x23 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 L 262 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 262 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 145 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL3 P 245 - G.H5 A 343 G.H5.10
Hydrophobic TM7 L 325 7x56 G.H5 L 358 G.H5.25
Hydrophobic H8 S 326 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 326 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Ionic ICL3 E 247 - G.S6 H 327 G.S6.04
Polar ICL3 E 247 - G.S6 H 327 G.S6.04
Hydrophobic ICL3 E 247 - G.S6 H 327 G.S6.04
Polar TM6 K 254 6x25 G.h4s6 S 320 G.h4s6.11
Polar ICL3 P 245 - G.S6 S 326 G.S6.03
Hydrophobic TM7 L 322 7x53 G.H5 N 357 G.H5.24
Van-der-waals ICL2 P 145 34x50 G.H5 N 352 G.H5.19
Hydrophobic ICL3 E 247 - G.H4 L 310 G.H4.12
Hydrophobic TM6 H 251 6x22 G.H4 V 314 G.H4.16
Hydrophobic TM5 L 237 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 P 245 - G.S6 Y 325 G.S6.02
Ionic TM6 K 254 6x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 Q 255 6x26 G.h4s6 I 323 G.h4s6.20
Polar TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 358 G.H5.25
Ionic ICL2 D 147 34x52 G.hns1 R 38 G.hns1.03
Polar H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 262 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Ionic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 259 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 259 6x30 G.H5 D 346 G.H5.13
Hydrophobic ICL3 V 246 - G.S6 Y 325 G.S6.02
Hydrophobic TM6 H 251 6x22 G.H4 K 311 G.H4.13
Hydrophobic ICL3 P 245 - G.H5 A 342 G.H5.09
Hydrophobic TM5 L 244 5x72 G.H5 D 346 G.H5.13
Hydrophobic ICL3 E 247 - G.S6 S 326 G.S6.03
Hydrophobic TM7 L 322 7x53 G.H5 L 358 G.H5.25
Polar TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM3 R 138 3x50 G.H5 L 358 G.H5.25
Polar ICL3 E 247 - G.S6 F 328 G.S6.05
Hydrophobic ICL3 E 247 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 E 247 - G.S6 F 328 G.S6.05
Hydrophobic ICL3 V 246 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 V 246 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 P 245 - G.H5 D 346 G.H5.13
Polar ICL2 Q 149 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 Q 149 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Q 149 34x54 G.hns1 R 37 G.hns1.02
Polar TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 352 G.H5.19
Polar TM6 Q 255 6x26 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 Q 255 6x26 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 L 262 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 262 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM2 P 75 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM5 L 237 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 145 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL3 P 245 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 P 245 - G.H5 F 339 G.H5.06
Polar TM6 Q 255 6x26 G.h4s6 S 320 G.h4s6.11