Refined structure (8JXX) of Gi1 - H4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 206 from structure (58.2%), 148 from model (41.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure AF2
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 260 from structure (81.2%), 60 from model (18.8%)
Residue sidechains - 252 from structure (78.8%), 68 from model (21.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 D - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 I - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 L - AF2 AF2
TM1 11 S 1.28x28 AF2 AF2
TM1 12 L 1.29x29 AF2 AF2
TM1 13 S 1.30x30 AF2 AF2
TM1 14 T 1.31x31 AF2 AF2
TM1 15 R 1.32x32 Structure AF2
TM1 16 V 1.33x33 Structure Structure
TM1 17 T 1.34x34 Structure Structure
TM1 18 L 1.35x35 Structure Structure
TM1 19 A 1.36x36 Structure Structure
TM1 20 F 1.37x37 Structure Structure
TM1 21 F 1.38x38 Structure Structure
TM1 22 M 1.39x39 Structure Structure
TM1 23 S 1.40x40 Structure Structure
TM1 24 L 1.41x41 Structure Structure
TM1 25 V 1.42x42 Structure Structure
TM1 26 A 1.43x43 Structure Structure
TM1 27 F 1.44x44 Structure Structure
TM1 28 A 1.45x45 Structure Structure
TM1 29 I 1.46x46 Structure Structure
TM1 30 M 1.47x47 Structure Structure
TM1 31 L 1.48x48 Structure Structure
TM1 32 G 1.49x49 Structure Structure
TM1 33 N 1.50x50 Structure Structure
TM1 34 A 1.51x51 Structure Structure
TM1 35 L 1.52x52 Structure Structure
TM1 36 V 1.53x53 Structure Structure
TM1 37 I 1.54x54 Structure Structure
TM1 38 L 1.55x55 Structure Structure
TM1 39 A 1.56x56 Structure Structure
TM1 40 F 1.57x57 Structure Structure
TM1 41 V 1.58x58 Structure Structure
TM1 42 V 1.59x59 Structure Structure
TM1 43 D 1.60x60 Structure Structure
ICL1 44 K 12.48x48 Structure Structure
ICL1 45 N 12.49x49 Structure Structure
ICL1 46 L 12.50x50 Structure Structure
ICL1 47 R 12.51x51 Structure Structure
TM2 48 H 2.37x37 Structure Structure
TM2 49 R 2.38x38 Structure Structure
TM2 50 S 2.39x39 Structure Structure
TM2 51 S 2.40x40 Structure Structure
TM2 52 Y 2.41x41 Structure Structure
TM2 53 F 2.42x42 Structure Structure
TM2 54 F 2.43x43 Structure Structure
TM2 55 L 2.44x44 Structure Structure
TM2 56 N 2.45x45 Structure Structure
TM2 57 L 2.46x46 Structure Structure
TM2 58 A 2.47x47 Structure Structure
TM2 59 I 2.48x48 Structure Structure
TM2 60 S 2.49x49 Structure Structure
TM2 61 D 2.50x50 Structure Structure
TM2 62 F 2.51x51 Structure Structure
TM2 63 F 2.52x52 Structure Structure
TM2 64 V 2.53x53 Structure Structure
TM2 65 G 2.54x54 Structure Structure
TM2 66 V 2.55x55 Structure Structure
TM2 67 I 2.56x551 Structure Structure
TM2 68 S 2.57x56 Structure Structure
TM2 69 I 2.58x57 Structure Structure
TM2 70 P 2.59x58 Structure Structure
TM2 71 L 2.60x59 Structure Structure
TM2 72 Y 2.61x60 Structure Structure
TM2 73 I 2.62x61 Structure Structure
TM2 74 P 2.63x62 Structure Structure
TM2 75 H 2.64x63 Structure Structure
TM2 76 T 2.65x64 Structure Structure
TM2 77 L 2.66x65 Structure Structure
ECL1 78 F - Structure Structure
ECL1 79 E 23.49x49 Structure AF2
ECL1 80 W 23.50x50 Structure Structure
ECL1 81 D 23.51x51 Structure AF2
ECL1 82 F 23.52x52 Structure Structure
TM3 83 G 3.21x21 Structure Structure
TM3 84 K 3.22x22 Structure AF2
TM3 85 E 3.23x23 Structure AF2
TM3 86 I 3.24x24 Structure Structure
TM3 87 C 3.25x25 Structure Structure
TM3 88 V 3.26x26 Structure Structure
TM3 89 F 3.27x27 Structure Structure
TM3 90 W 3.28x28 Structure Structure
TM3 91 L 3.29x29 Structure Structure
TM3 92 T 3.30x30 Structure Structure
TM3 93 T 3.31x31 Structure Structure
TM3 94 D 3.32x32 Structure Structure
TM3 95 Y 3.33x33 Structure Structure
TM3 96 L 3.34x34 Structure Structure
TM3 97 L 3.35x35 Structure Structure
TM3 98 C 3.36x36 Structure Structure
TM3 99 T 3.37x37 Structure Structure
TM3 100 A 3.38x38 Structure Structure
TM3 101 S 3.39x39 Structure Structure
TM3 102 V 3.40x40 Structure Structure
TM3 103 Y 3.41x41 Structure Structure
TM3 104 N 3.42x42 Structure Structure
TM3 105 I 3.43x43 Structure Structure
TM3 106 V 3.44x44 Structure Structure
TM3 107 L 3.45x45 Structure Structure
TM3 108 I 3.46x46 Structure Structure
TM3 109 S 3.47x47 Structure Structure
TM3 110 Y 3.48x48 Structure Structure
TM3 111 D 3.49x49 Structure Structure
TM3 112 R 3.50x50 Structure Structure
TM3 113 Y 3.51x51 Structure Structure
TM3 114 L 3.52x52 Structure Structure
TM3 115 S 3.53x53 Structure Structure
TM3 116 V 3.54x54 Structure Structure
TM3 117 S 3.55x55 Structure Structure
TM3 118 N 3.56x56 Structure Structure
ICL2 119 A 34.50x50 Structure Structure
ICL2 120 V 34.51x51 Structure Structure
ICL2 121 S 34.52x52 Structure Structure
ICL2 122 Y 34.53x53 Structure Structure
ICL2 123 R 34.54x54 Structure Structure
ICL2 124 T 34.55x55 Structure Structure
ICL2 125 Q 34.56x56 Structure Structure
ICL2 126 H - Structure Structure
ICL2 127 T - Structure Structure
TM4 128 G 4.38x38 Structure Structure
TM4 129 V 4.39x39 Structure Structure
TM4 130 L 4.40x40 Structure Structure
TM4 131 K 4.41x41 Structure Structure
TM4 132 I 4.42x42 Structure Structure
TM4 133 V 4.43x43 Structure Structure
TM4 134 T 4.44x44 Structure Structure
TM4 135 L 4.45x45 Structure Structure
TM4 136 M 4.46x46 Structure Structure
TM4 137 V 4.47x47 Structure Structure
TM4 138 A 4.48x48 Structure Structure
TM4 139 V 4.49x49 Structure Structure
TM4 140 W 4.50x50 Structure Structure
TM4 141 V 4.51x51 Structure Structure
TM4 142 L 4.52x52 Structure Structure
TM4 143 A 4.53x53 Structure Structure
TM4 144 F 4.54x54 Structure Structure
TM4 145 L 4.55x55 Structure Structure
TM4 146 V 4.56x56 Structure Structure
TM4 147 N 4.57x57 Structure Structure
TM4 148 G 4.58x59 Structure Structure
TM4 149 P 4.59x60 Structure Structure
TM4 150 M 4.60x61 Structure Structure
TM4 151 I 4.61x62 Structure Structure
TM4 152 L 4.62x63 Structure Structure
TM4 153 V 4.63x64 Structure Structure
TM4 154 S 4.64x65 Structure Structure
TM4 155 E 4.65x66 Structure Structure
TM4 156 S 4.66x67 Structure Structure
TM4 157 W 4.67x68 Structure Structure
TM4 158 K 4.68x69 AF2 AF2
ECL2 159 D - AF2 AF2
ECL2 160 E - AF2 AF2
ECL2 161 G - AF2 AF2
ECL2 162 S - AF2 AF2
ECL2 163 E - Structure AF2
ECL2 164 C 45.50x50 Structure Structure
ECL2 165 E 45.51x51 Structure Structure
ECL2 166 P 45.52x52 Structure Structure
ECL2 167 G - Structure Structure
ECL2 168 F - Structure Structure
ECL2 169 F - Structure Structure
ECL2 170 S - Structure Structure
TM5 171 E 5.35x36 Structure Structure
TM5 172 W 5.36x37 Structure Structure
TM5 173 Y 5.37x38 Structure Structure
TM5 174 I 5.38x39 Structure Structure
TM5 175 L 5.39x40 Structure Structure
TM5 176 A 5.40x41 Structure Structure
TM5 177 I 5.41x42 Structure Structure
TM5 178 T 5.42x43 Structure Structure
TM5 179 S 5.43x44 Structure Structure
TM5 180 F 5.44x45 Structure Structure
TM5 181 L 5.45x46 Structure Structure
TM5 182 E 5.46x461 Structure Structure
TM5 183 F 5.47x47 Structure Structure
TM5 184 V 5.48x48 Structure Structure
TM5 185 I 5.49x49 Structure Structure
TM5 186 P 5.50x50 Structure Structure
TM5 187 V 5.51x51 Structure Structure
TM5 188 I 5.52x52 Structure Structure
TM5 189 L 5.53x53 Structure Structure
TM5 190 V 5.54x54 Structure Structure
TM5 191 A 5.55x55 Structure Structure
TM5 192 Y 5.56x56 Structure Structure
TM5 193 F 5.57x57 Structure Structure
TM5 194 N 5.58x58 Structure Structure
TM5 195 M 5.59x59 Structure Structure
TM5 196 N 5.60x60 Structure Structure
TM5 197 I 5.61x61 Structure Structure
TM5 198 Y 5.62x62 Structure Structure
TM5 199 W 5.63x63 Structure Structure
TM5 200 S 5.64x64 Structure Structure
TM5 201 L 5.65x65 Structure Structure
TM5 202 W 5.66x66 Structure Structure
TM5 203 K 5.67x67 Structure Structure
TM5 204 R 5.68x68 AF2 AF2
TM5 205 D 5.69x69 AF2 AF2
TM5 206 H 5.70x70 AF2 AF2
TM5 207 L 5.71x71 AF2 AF2
TM5 208 S 5.72x72 AF2 AF2
TM5 209 R 5.73x73 AF2 AF2
TM5 210 C 5.74x74 AF2 AF2
TM5 211 Q 5.75x75 AF2 AF2
TM5 212 S 5.76x76 AF2 AF2
ICL3 213 H - AF2 AF2
ICL3 214 P - AF2 AF2
ICL3 215 G - AF2 AF2
ICL3 216 L - AF2 AF2
ICL3 217 T - AF2 AF2
ICL3 218 A - AF2 AF2
ICL3 219 V - AF2 AF2
ICL3 285 V - AF2 AF2
ICL3 286 A - AF2 AF2
ICL3 287 L - AF2 AF2
ICL3 288 H - AF2 AF2
ICL3 289 Q - AF2 AF2
ICL3 290 R - AF2 AF2
ICL3 291 E - AF2 AF2
TM6 292 H 6.24x24 AF2 AF2
TM6 293 V 6.25x25 Structure Structure
TM6 294 E 6.26x26 Structure AF2
TM6 295 L 6.27x27 Structure Structure
TM6 296 L 6.28x28 Structure Structure
TM6 297 R 6.29x29 Structure Structure
TM6 298 A 6.30x30 Structure Structure
TM6 299 R 6.31x31 Structure Structure
TM6 300 R 6.32x32 Structure Structure
TM6 301 L 6.33x33 Structure Structure
TM6 302 A 6.34x34 Structure Structure
TM6 303 K 6.35x35 Structure Structure
TM6 304 S 6.36x36 Structure Structure
TM6 305 L 6.37x37 Structure Structure
TM6 306 A 6.38x38 Structure Structure
TM6 307 I 6.39x39 Structure Structure
TM6 308 L 6.40x40 Structure Structure
TM6 309 L 6.41x41 Structure Structure
TM6 310 G 6.42x42 Structure Structure
TM6 311 V 6.43x43 Structure Structure
TM6 312 F 6.44x44 Structure Structure
TM6 313 A 6.45x45 Structure Structure
TM6 314 V 6.46x46 Structure Structure
TM6 315 C 6.47x47 Structure Structure
TM6 316 W 6.48x48 Structure Structure
TM6 317 A 6.49x49 Structure Structure
TM6 318 P 6.50x50 Structure Structure
TM6 319 Y 6.51x51 Structure Structure
TM6 320 S 6.52x52 Structure Structure
TM6 321 L 6.53x53 Structure Structure
TM6 322 F 6.54x54 Structure Structure
TM6 323 T 6.55x55 Structure Structure
TM6 324 I 6.56x56 Structure Structure
TM6 325 V 6.57x57 Structure Structure
TM6 326 L 6.58x58 Structure Structure
TM6 327 S 6.59x59 Structure Structure
TM6 328 F 6.60x60 Structure Structure
TM6 329 Y 6.61x61 Structure Structure
ECL3 330 S - Structure Structure
ECL3 331 S - Structure Structure
ECL3 332 A - AF2 AF2
ECL3 333 T - AF2 AF2
ECL3 334 G - AF2 AF2
ECL3 335 P - AF2 AF2
ECL3 336 K - Structure Structure
TM7 337 S 7.32x31 Structure Structure
TM7 338 V 7.33x32 Structure Structure
TM7 339 W 7.34x33 Structure Structure
TM7 340 Y 7.35x34 Structure Structure
TM7 341 R 7.36x35 Structure AF2
TM7 342 I 7.37x36 Structure Structure
TM7 343 A 7.38x37 Structure Structure
TM7 344 F 7.39x38 Structure Structure
TM7 345 W 7.40x39 Structure Structure
TM7 346 L 7.41x40 Structure Structure
TM7 347 Q 7.42x41 Structure Structure
TM7 348 W 7.43x42 Structure Structure
TM7 349 F 7.44x43 Structure Structure
TM7 350 N 7.45x45 Structure Structure
TM7 351 S 7.46x46 Structure Structure
TM7 352 F 7.47x47 Structure Structure
TM7 353 V 7.48x48 Structure Structure
TM7 354 N 7.49x49 Structure Structure
TM7 355 P 7.50x50 Structure Structure
TM7 356 L 7.51x51 Structure Structure
TM7 357 L 7.52x52 Structure Structure
TM7 358 Y 7.53x53 Structure Structure
TM7 359 P 7.54x54 Structure Structure
TM7 360 L 7.55x55 Structure Structure
TM7 361 C 7.56x56 Structure Structure
H8 362 H 8.47x47 Structure Structure
H8 363 K 8.48x48 Structure Structure
H8 364 R 8.49x49 Structure Structure
H8 365 F 8.50x50 Structure Structure
H8 366 Q 8.51x51 Structure Structure
H8 367 K 8.52x52 Structure Structure
H8 368 A 8.53x53 Structure Structure
H8 369 F 8.54x54 Structure Structure
H8 370 L 8.55x55 Structure Structure
H8 371 K 8.56x56 Structure Structure
H8 372 I 8.57x57 Structure Structure
H8 373 F 8.58x58 AF2 AF2
H8 374 C 8.59x59 AF2 AF2
H8 375 I 8.60x60 AF2 AF2
C-term 376 K - AF2 AF2
C-term 377 K - AF2 AF2
C-term 378 Q - AF2 AF2
C-term 379 P - AF2 AF2
C-term 380 L - AF2 AF2
C-term 381 P - AF2 AF2
C-term 382 S - AF2 AF2
C-term 383 Q - AF2 AF2
C-term 384 H - AF2 AF2
C-term 385 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 H 362 8x47 G.H5 C 351 G.H5.23
Polar C-term S 385 - G.H2 H 213 G.H2.09
Hydrophobic C-term S 385 - G.H2 H 213 G.H2.09
Van-der-waals C-term S 385 - G.H2 H 213 G.H2.09
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Polar TM5 R 204 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 R 204 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 204 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM5 I 197 5x61 G.H5 L 353 G.H5.25
Polar TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Polar C-term H 384 - G.H2 H 213 G.H2.09
Hydrophobic C-term H 384 - G.H2 H 213 G.H2.09
Van-der-waals C-term H 384 - G.H2 H 213 G.H2.09
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Polar C-term S 385 - G.H2 I 212 G.H2.08
Hydrophobic C-term S 385 - G.H2 I 212 G.H2.08
Van-der-waals C-term S 385 - G.H2 I 212 G.H2.08
Polar C-term Q 383 - G.h2s4 E 216 G.h2s4.02
Ionic C-term H 384 - G.h2s4 E 216 G.h2s4.02
Ionic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 204 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar ICL3 R 290 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 G 215 - G.H4 A 301 G.H4.08
Hydrophobic TM5 R 204 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 204 5x68 G.H5 I 344 G.H5.16
Polar C-term S 385 - G.H2 W 211 G.H2.07
Hydrophobic C-term S 385 - G.H2 W 211 G.H2.07
Van-der-waals C-term S 385 - G.H2 W 211 G.H2.07
Hydrophobic C-term P 381 - G.H3 W 258 G.H3.17
Van-der-waals C-term P 381 - G.H3 W 258 G.H3.17
Polar C-term Q 383 - G.H2 C 214 G.H2.10
Polar C-term H 384 - G.H2 C 214 G.H2.10
Hydrophobic C-term H 384 - G.H2 C 214 G.H2.10
Van-der-waals C-term H 384 - G.H2 C 214 G.H2.10
Polar H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 301 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 201 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 201 5x65 G.H5 F 354 G.H5.26
Ionic ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Polar C-term Q 383 - G.H2 H 213 G.H2.09
Hydrophobic C-term Q 383 - G.H2 H 213 G.H2.09
Van-der-waals C-term Q 383 - G.H2 H 213 G.H2.09
Polar C-term S 385 - G.H2 K 210 G.H2.06
Hydrophobic C-term S 385 - G.H2 K 210 G.H2.06
Van-der-waals C-term S 385 - G.H2 K 210 G.H2.06
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Polar ICL3 A 286 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 V 116 3x54 G.H5 I 344 G.H5.16
Polar C-term Q 383 - G.H3 K 257 G.H3.16
Hydrophobic C-term Q 383 - G.H3 K 257 G.H3.16
Van-der-waals C-term Q 383 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 V 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic C-term S 385 - G.H2 K 209 G.H2.05
Van-der-waals C-term S 385 - G.H2 K 209 G.H2.05
Polar C-term Q 383 - G.H3 W 258 G.H3.17
Hydrophobic C-term Q 383 - G.H3 W 258 G.H3.17
Van-der-waals C-term Q 383 - G.H3 W 258 G.H3.17
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19
Polar TM7 C 361 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 C 361 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 C 361 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 A 218 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 A 218 - G.H4 C 305 G.H4.13
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 353 G.H5.25
Ionic TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Ionic ICL3 R 290 - G.H4 E 308 G.H4.16
Polar ICL3 R 290 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 290 - G.H4 E 308 G.H4.16
Hydrophobic TM6 L 301 6x33 G.H5 L 348 G.H5.20