OT receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Aug. 10, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

vasopressin, oxytocin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 I 227 5x65 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 227 5x65 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 144 - G.H5 L 344 G.H5.16
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM2 L 74 2x39 G.H5 Y 351 G.H5.23
Van-der-waals TM2 L 74 2x39 G.H5 Y 351 G.H5.23
Polar TM3 D 136 3x49 G.H5 Y 351 G.H5.23
Van-der-waals TM3 D 136 3x49 G.H5 Y 351 G.H5.23
Hydrophobic ICL2 P 144 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 144 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 141 3x54 G.H5 Y 351 G.H5.23
Hydrophobic TM3 A 140 3x53 G.H5 Y 351 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 Y 351 G.H5.23
Ionic TM2 R 73 2x38 G.H5 E 350 G.H5.22
Polar TM2 R 73 2x38 G.H5 E 350 G.H5.22
Van-der-waals TM5 N 230 5x68 G.H5 Q 345 G.H5.17
Hydrophobic H8 T 333 8x47 G.H5 N 352 G.H5.24
Polar TM2 R 73 2x38 G.H5 Y 351 G.H5.23
Hydrophobic TM2 R 73 2x38 G.H5 Y 351 G.H5.23
Van-der-waals TM2 R 73 2x38 G.H5 Y 351 G.H5.23
Hydrophobic TM6 R 272 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 N 347 G.H5.19
Polar TM6 R 272 6x32 G.H5 V 354 G.H5.26
Hydrophobic TM6 R 272 6x32 G.H5 V 354 G.H5.26
Van-der-waals TM6 R 272 6x32 G.H5 V 354 G.H5.26
Hydrophobic TM2 L 74 2x39 G.H5 N 352 G.H5.24
Van-der-waals TM2 L 74 2x39 G.H5 N 352 G.H5.24
Van-der-waals ICL2 P 144 - G.H5 N 347 G.H5.19
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Polar H8 H 335 8x49 G.H5 N 352 G.H5.24
Hydrophobic H8 H 335 8x49 G.H5 N 352 G.H5.24
Van-der-waals H8 H 335 8x49 G.H5 N 352 G.H5.24
Polar TM3 R 137 3x50 G.H5 Y 351 G.H5.23
Aromatic TM3 R 137 3x50 G.H5 Y 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 Y 351 G.H5.23
Hydrophobic TM3 I 141 3x54 G.H5 L 348 G.H5.20