GPCRdb

Refined structure (6OIK) of G_o - M₂ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 201 from structure (56.8%), 153 from model (43.2%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	E	G.HN.33	Structure	AF2
G.HN	10	R	G.HN.34	Structure	AF2
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	L	G.HN.37	Structure	AF2
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	A	G.HN.42	Structure	AF2
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	E	G.HN.44	Structure	AF2
G.HN	21	K	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	K	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	AF2
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	I	G.HN.52	Structure	Structure
G.HN	29	S	G.HN.53	Structure	AF2
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	K	G.hns1.03	Structure	Structure
G.S1	33	D	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	Structure	Structure
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	D	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	F	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	G	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	D	H.HA.03	AF2	AF2
H.HA	66	V	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	P	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	L	H.HA.19	AF2	AF2
H.HA	82	A	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	V	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	D	H.HA.27	AF2	AF2
H.HA	90	T	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	G	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	E	H.hahb.05	AF2	AF2
H.hahb	95	Y	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	K	H.hahb.09	AF2	AF2
H.HB	99	E	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	K	H.HB.03	AF2	AF2
H.HB	102	A	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	K	H.HB.07	AF2	AF2
H.HB	106	M	H.HB.08	AF2	AF2
H.HB	107	V	H.HB.09	AF2	AF2
H.HB	108	C	H.HB.10	AF2	AF2
H.HB	109	D	H.HB.11	AF2	AF2
H.HB	110	V	H.HB.12	AF2	AF2
H.HB	111	V	H.HB.13	AF2	AF2
H.HB	112	S	H.HB.14	AF2	AF2
H.hbhc	113	R	H.hbhc.01	AF2	AF2
H.hbhc	114	M	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	D	H.hbhc.04	AF2	AF2
H.hbhc	117	T	H.hbhc.05	AF2	AF2
H.hbhc	118	E	H.hbhc.12	AF2	AF2
H.hbhc	119	P	H.hbhc.13	AF2	AF2
H.hbhc	120	F	H.hbhc.14	AF2	AF2
H.hbhc	121	S	H.hbhc.15	AF2	AF2
H.HC	122	A	H.HC.01	AF2	AF2
H.HC	123	E	H.HC.02	AF2	AF2
H.HC	124	L	H.HC.03	AF2	AF2
H.HC	125	L	H.HC.04	AF2	AF2
H.HC	126	S	H.HC.05	AF2	AF2
H.HC	127	A	H.HC.06	AF2	AF2
H.HC	128	M	H.HC.07	AF2	AF2
H.HC	129	M	H.HC.08	AF2	AF2
H.HC	130	R	H.HC.09	AF2	AF2
H.HC	131	L	H.HC.10	AF2	AF2
H.HC	132	W	H.HC.11	AF2	AF2
H.HC	133	G	H.HC.12	AF2	AF2
H.hchd	134	D	H.hchd.01	AF2	AF2
H.HD	135	S	H.HD.01	AF2	AF2
H.HD	136	G	H.HD.02	AF2	AF2
H.HD	137	I	H.HD.03	AF2	AF2
H.HD	138	Q	H.HD.04	AF2	AF2
H.HD	139	E	H.HD.05	AF2	AF2
H.HD	140	C	H.HD.06	AF2	AF2
H.HD	141	F	H.HD.07	AF2	AF2
H.HD	142	N	H.HD.08	AF2	AF2
H.HD	143	R	H.HD.09	AF2	AF2
H.HD	144	S	H.HD.10	AF2	AF2
H.HD	145	R	H.HD.11	AF2	AF2
H.HD	146	E	H.HD.12	AF2	AF2
H.hdhe	147	Y	H.hdhe.01	AF2	AF2
H.hdhe	148	Q	H.hdhe.02	AF2	AF2
H.hdhe	149	L	H.hdhe.03	AF2	AF2
H.hdhe	150	N	H.hdhe.04	AF2	AF2
H.hdhe	151	D	H.hdhe.05	AF2	AF2
H.HE	152	S	H.HE.01	AF2	AF2
H.HE	153	A	H.HE.02	AF2	AF2
H.HE	154	K	H.HE.03	AF2	AF2
H.HE	155	Y	H.HE.04	AF2	AF2
H.HE	156	Y	H.HE.05	AF2	AF2
H.HE	157	L	H.HE.06	AF2	AF2
H.HE	158	D	H.HE.07	AF2	AF2
H.HE	159	S	H.HE.08	AF2	AF2
H.HE	160	L	H.HE.09	AF2	AF2
H.HE	161	D	H.HE.10	AF2	AF2
H.HE	162	R	H.HE.11	AF2	AF2
H.HE	163	I	H.HE.12	AF2	AF2
H.HE	164	G	H.HE.13	AF2	AF2
H.hehf	165	A	H.hehf.01	AF2	AF2
H.hehf	166	A	H.hehf.02	AF2	AF2
H.hehf	167	D	H.hehf.03	AF2	AF2
H.hehf	168	Y	H.hehf.04	AF2	AF2
H.hehf	169	Q	H.hehf.05	AF2	AF2
H.hehf	170	P	H.hehf.06	AF2	AF2
H.hehf	171	T	H.hehf.07	AF2	AF2
H.HF	172	E	H.HF.01	AF2	AF2
H.HF	173	Q	H.HF.02	AF2	AF2
H.HF	174	D	H.HF.03	AF2	AF2
H.HF	175	I	H.HF.04	AF2	AF2
H.HF	176	L	H.HF.05	AF2	AF2
H.HF	177	R	H.HF.06	AF2	AF2
G.hfs2	178	T	G.hfs2.01	AF2	AF2
G.hfs2	179	R	G.hfs2.02	AF2	AF2
G.hfs2	180	V	G.hfs2.03	AF2	AF2
G.hfs2	181	K	G.hfs2.04	AF2	AF2
G.hfs2	182	T	G.hfs2.05	Structure	Structure
G.hfs2	183	T	G.hfs2.06	Structure	Structure
G.hfs2	184	G	G.hfs2.07	Structure	Structure
G.S2	185	I	G.S2.01	Structure	Structure
G.S2	186	V	G.S2.02	Structure	Structure
G.S2	187	E	G.S2.03	Structure	Structure
G.S2	188	T	G.S2.04	Structure	Structure
G.S2	189	H	G.S2.05	Structure	Structure
G.S2	190	F	G.S2.06	Structure	Structure
G.S2	191	T	G.S2.07	Structure	Structure
G.S2	192	F	G.S2.08	Structure	Structure
G.s2s3	193	K	G.s2s3.01	Structure	Structure
G.s2s3	194	N	G.s2s3.02	Structure	Structure
G.S3	195	L	G.S3.01	Structure	Structure
G.S3	196	H	G.S3.02	Structure	AF2
G.S3	197	F	G.S3.03	Structure	Structure
G.S3	198	R	G.S3.04	Structure	Structure
G.S3	199	L	G.S3.05	Structure	Structure
G.S3	200	F	G.S3.06	Structure	Structure
G.S3	201	D	G.S3.07	Structure	Structure
G.S3	202	V	G.S3.08	Structure	Structure
G.s3h2	203	G	G.s3h2.01	Structure	Structure
G.s3h2	204	G	G.s3h2.02	Structure	Structure
G.s3h2	205	Q	G.s3h2.03	Structure	Structure
G.H2	206	R	G.H2.01	Structure	Structure
G.H2	207	S	G.H2.02	Structure	Structure
G.H2	208	E	G.H2.03	Structure	Structure
G.H2	209	R	G.H2.04	Structure	Structure
G.H2	210	K	G.H2.05	Structure	Structure
G.H2	211	K	G.H2.06	Structure	Structure
G.H2	212	W	G.H2.07	Structure	Structure
G.H2	213	I	G.H2.08	Structure	Structure
G.H2	214	H	G.H2.09	Structure	Structure
G.H2	215	C	G.H2.10	Structure	Structure
G.h2s4	216	F	G.h2s4.01	Structure	Structure
G.h2s4	217	E	G.h2s4.02	Structure	Structure
G.h2s4	218	D	G.h2s4.03	Structure	Structure
G.h2s4	219	V	G.h2s4.04	Structure	Structure
G.h2s4	220	T	G.h2s4.05	Structure	Structure
G.S4	221	A	G.S4.01	Structure	Structure
G.S4	222	I	G.S4.02	Structure	Structure
G.S4	223	I	G.S4.03	Structure	Structure
G.S4	224	F	G.S4.04	Structure	Structure
G.S4	225	C	G.S4.05	Structure	Structure
G.S4	226	V	G.S4.06	Structure	Structure
G.S4	227	A	G.S4.07	Structure	Structure
G.s4h3	228	L	G.s4h3.01	Structure	Structure
G.s4h3	229	S	G.s4h3.02	Structure	AF2
G.s4h3	230	G	G.s4h3.03	Structure	Structure
G.s4h3	231	Y	G.s4h3.04	Structure	Structure
G.s4h3	232	D	G.s4h3.05	Structure	Structure
G.s4h3	233	Q	G.s4h3.06	Structure	Structure
G.s4h3	234	V	G.s4h3.07	AF2	AF2
G.s4h3	235	L	G.s4h3.08	AF2	AF2
G.s4h3	236	H	G.s4h3.09	AF2	AF2
G.s4h3	237	E	G.s4h3.10	AF2	AF2
G.s4h3	238	D	G.s4h3.11	AF2	AF2
G.s4h3	239	E	G.s4h3.12	AF2	AF2
G.s4h3	240	T	G.s4h3.13	AF2	AF2
G.s4h3	241	T	G.s4h3.14	AF2	AF2
G.s4h3	242	N	G.s4h3.15	Structure	Structure
G.H3	243	R	G.H3.01	Structure	Structure
G.H3	244	M	G.H3.02	Structure	Structure
G.H3	245	H	G.H3.03	Structure	Structure
G.H3	246	E	G.H3.04	Structure	Structure
G.H3	247	S	G.H3.05	Structure	Structure
G.H3	248	L	G.H3.06	Structure	Structure
G.H3	249	M	G.H3.07	Structure	AF2
G.H3	250	L	G.H3.08	Structure	Structure
G.H3	251	F	G.H3.09	Structure	Structure
G.H3	252	D	G.H3.10	Structure	Structure
G.H3	253	S	G.H3.11	Structure	Structure
G.H3	254	I	G.H3.12	Structure	Structure
G.H3	255	C	G.H3.13	Structure	Structure
G.H3	256	N	G.H3.14	Structure	Structure
G.H3	257	N	G.H3.15	Structure	Structure
G.H3	258	K	G.H3.16	Structure	Structure
G.H3	259	F	G.H3.17	Structure	Structure
G.H3	260	F	G.H3.18	Structure	Structure
G.h3s5	261	I	G.h3s5.01	Structure	Structure
G.h3s5	262	D	G.h3s5.02	Structure	AF2
G.h3s5	263	T	G.h3s5.03	Structure	Structure
G.S5	264	S	G.S5.01	Structure	Structure
G.S5	265	I	G.S5.02	Structure	Structure
G.S5	266	I	G.S5.03	Structure	Structure
G.S5	267	L	G.S5.04	Structure	Structure
G.S5	268	F	G.S5.05	Structure	Structure
G.S5	269	L	G.S5.06	Structure	Structure
G.S5	270	N	G.S5.07	Structure	Structure
G.s5hg	271	K	G.s5hg.01	Structure	Structure
G.HG	272	K	G.HG.01	Structure	Structure
G.HG	273	D	G.HG.02	Structure	Structure
G.HG	274	L	G.HG.03	Structure	Structure
G.HG	275	F	G.HG.04	Structure	Structure
G.HG	276	G	G.HG.05	Structure	Structure
G.HG	277	E	G.HG.06	Structure	Structure
G.HG	278	K	G.HG.07	Structure	Structure
G.HG	279	I	G.HG.08	Structure	Structure
G.HG	280	K	G.HG.09	Structure	AF2
G.HG	281	K	G.HG.12	Structure	AF2
G.HG	282	S	G.HG.13	Structure	Structure
G.HG	283	P	G.HG.14	Structure	Structure
G.HG	284	L	G.HG.15	Structure	Structure
G.HG	285	T	G.HG.16	Structure	Structure
G.HG	286	I	G.HG.17	Structure	Structure
G.hgh4	287	C	G.hgh4.01	Structure	Structure
G.hgh4	288	F	G.hgh4.02	Structure	Structure
G.hgh4	289	P	G.hgh4.03	Structure	Structure
G.hgh4	290	E	G.hgh4.04	Structure	Structure
G.hgh4	291	Y	G.hgh4.05	Structure	Structure
G.hgh4	292	T	G.hgh4.06	Structure	Structure
G.hgh4	293	G	G.hgh4.07	Structure	Structure
G.hgh4	294	P	G.hgh4.08	Structure	Structure
G.H4	295	N	G.H4.01	Structure	Structure
G.H4	296	T	G.H4.02	Structure	Structure
G.H4	297	Y	G.H4.03	Structure	Structure
G.H4	298	E	G.H4.04	Structure	AF2
G.H4	299	D	G.H4.05	Structure	Structure
G.H4	300	A	G.H4.06	Structure	Structure
G.H4	301	A	G.H4.07	Structure	Structure
G.H4	302	A	G.H4.08	Structure	Structure
G.H4	303	Y	G.H4.10	Structure	Structure
G.H4	304	I	G.H4.11	Structure	Structure
G.H4	305	Q	G.H4.12	Structure	Structure
G.H4	306	A	G.H4.13	Structure	Structure
G.H4	307	Q	G.H4.14	Structure	Structure
G.H4	308	F	G.H4.15	Structure	Structure
G.H4	309	E	G.H4.16	Structure	Structure
G.H4	310	S	G.H4.17	Structure	Structure
G.h4s6	311	K	G.h4s6.01	Structure	Structure
G.h4s6	312	N	G.h4s6.02	Structure	Structure
G.h4s6	313	R	G.h4s6.03	Structure	Structure
G.h4s6	314	S	G.h4s6.08	Structure	Structure
G.h4s6	315	P	G.h4s6.09	Structure	Structure
G.h4s6	316	N	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	C	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	M	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	Structure
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	AF2
G.H5	329	T	G.H5.01	Structure	AF2
G.H5	330	N	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	I	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	V	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	I	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	A	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	R	G.H5.21	Structure	Structure
G.H5	350	G	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	Y	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 278 from structure (84.8%), 50 from model (15.2%)
Residue sidechains - 245 from structure (74.7%), 83 from model (25.3%)

Showing 1 to 328 of 328 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	N	-	AF2	AF2
N-term	3	N	-	AF2	AF2
N-term	4	S	-	AF2	AF2
N-term	5	T	-	AF2	AF2
N-term	6	N	-	AF2	AF2
N-term	7	S	-	AF2	AF2
N-term	8	S	-	AF2	AF2
N-term	9	N	-	AF2	AF2
N-term	10	N	-	AF2	AF2
N-term	11	S	-	AF2	AF2
N-term	12	L	-	AF2	AF2
N-term	13	A	-	AF2	AF2
N-term	14	L	-	AF2	AF2
N-term	15	T	-	AF2	AF2
N-term	16	S	-	AF2	AF2
N-term	17	P	-	AF2	AF2
N-term	18	Y	-	AF2	AF2
TM1	19	K	1.28x28	AF2	AF2
TM1	20	T	1.29x29	Structure	AF2
TM1	21	F	1.30x30	Structure	AF2
TM1	22	E	1.31x31	Structure	AF2
TM1	23	V	1.32x32	Structure	AF2
TM1	24	V	1.33x33	Structure	Structure
TM1	25	F	1.34x34	Structure	Structure
TM1	26	I	1.35x35	Structure	AF2
TM1	27	V	1.36x36	Structure	Structure
TM1	28	L	1.37x37	Structure	AF2
TM1	29	V	1.38x38	Structure	Structure
TM1	30	A	1.39x39	Structure	Structure
TM1	31	G	1.40x40	Structure	Structure
TM1	32	S	1.41x41	Structure	Structure
TM1	33	L	1.42x42	Structure	Structure
TM1	34	S	1.43x43	Structure	Structure
TM1	35	L	1.44x44	Structure	Structure
TM1	36	V	1.45x45	Structure	Structure
TM1	37	T	1.46x46	Structure	Structure
TM1	38	I	1.47x47	Structure	Structure
TM1	39	I	1.48x48	Structure	Structure
TM1	40	G	1.49x49	Structure	Structure
TM1	41	N	1.50x50	Structure	Structure
TM1	42	I	1.51x51	Structure	AF2
TM1	43	L	1.52x52	Structure	Structure
TM1	44	V	1.53x53	Structure	Structure
TM1	45	M	1.54x54	Structure	Structure
TM1	46	V	1.55x55	Structure	Structure
TM1	47	S	1.56x56	Structure	Structure
TM1	48	I	1.57x57	Structure	Structure
TM1	49	K	1.58x58	Structure	AF2
TM1	50	V	1.59x59	Structure	AF2
TM1	51	N	1.60x60	Structure	Structure
ICL1	52	R	12.48x48	Structure	AF2
ICL1	53	H	12.49x49	Structure	Structure
ICL1	54	L	12.50x50	Structure	Structure
ICL1	55	Q	12.51x51	Structure	AF2
TM2	56	T	2.37x37	Structure	Structure
TM2	57	V	2.38x38	Structure	Structure
TM2	58	N	2.39x39	Structure	Structure
TM2	59	N	2.40x40	Structure	Structure
TM2	60	Y	2.41x41	Structure	Structure
TM2	61	F	2.42x42	Structure	Structure
TM2	62	L	2.43x43	Structure	Structure
TM2	63	F	2.44x44	Structure	Structure
TM2	64	S	2.45x45	Structure	Structure
TM2	65	L	2.46x46	Structure	Structure
TM2	66	A	2.47x47	Structure	Structure
TM2	67	C	2.48x48	Structure	Structure
TM2	68	A	2.49x49	Structure	Structure
TM2	69	D	2.50x50	Structure	Structure
TM2	70	L	2.51x51	Structure	AF2
TM2	71	I	2.52x52	Structure	Structure
TM2	72	I	2.53x53	Structure	Structure
TM2	73	G	2.54x54	Structure	Structure
TM2	74	V	2.55x55	Structure	AF2
TM2	75	F	2.56x551	Structure	Structure
TM2	76	S	2.57x56	Structure	Structure
TM2	77	M	2.58x57	Structure	Structure
TM2	78	N	2.59x58	Structure	Structure
TM2	79	L	2.60x59	Structure	Structure
TM2	80	Y	2.61x60	Structure	Structure
TM2	81	T	2.62x61	Structure	Structure
TM2	82	L	2.63x62	Structure	Structure
TM2	83	Y	2.64x63	Structure	Structure
TM2	84	T	2.65x64	Structure	Structure
TM2	85	V	2.66x65	Structure	Structure
TM2	86	I	2.67x66	Structure	Structure
TM2	87	G	2.68x67	Structure	Structure
ECL1	88	Y	23.49x49	Structure	Structure
ECL1	89	W	23.50x50	Structure	Structure
ECL1	90	P	23.51x51	Structure	Structure
ECL1	91	L	23.52x52	Structure	AF2
TM3	92	G	3.21x21	Structure	Structure
TM3	93	P	3.22x22	Structure	Structure
TM3	94	V	3.23x23	Structure	Structure
TM3	95	V	3.24x24	Structure	Structure
TM3	96	C	3.25x25	Structure	Structure
TM3	97	D	3.26x26	Structure	AF2
TM3	98	L	3.27x27	Structure	AF2
TM3	99	W	3.28x28	Structure	Structure
TM3	100	L	3.29x29	Structure	Structure
TM3	101	A	3.30x30	Structure	Structure
TM3	102	L	3.31x31	Structure	Structure
TM3	103	D	3.32x32	Structure	Structure
TM3	104	Y	3.33x33	Structure	Structure
TM3	105	V	3.34x34	Structure	Structure
TM3	106	V	3.35x35	Structure	Structure
TM3	107	S	3.36x36	Structure	Structure
TM3	108	N	3.37x37	Structure	Structure
TM3	109	A	3.38x38	Structure	Structure
TM3	110	S	3.39x39	Structure	Structure
TM3	111	V	3.40x40	Structure	Structure
TM3	112	M	3.41x41	Structure	Structure
TM3	113	N	3.42x42	Structure	Structure
TM3	114	L	3.43x43	Structure	Structure
TM3	115	L	3.44x44	Structure	Structure
TM3	116	I	3.45x45	Structure	Structure
TM3	117	I	3.46x46	Structure	Structure
TM3	118	S	3.47x47	Structure	Structure
TM3	119	F	3.48x48	Structure	Structure
TM3	120	D	3.49x49	Structure	Structure
TM3	121	R	3.50x50	Structure	Structure
TM3	122	Y	3.51x51	Structure	Structure
TM3	123	F	3.52x52	Structure	Structure
TM3	124	C	3.53x53	Structure	Structure
TM3	125	V	3.54x54	Structure	Structure
TM3	126	T	3.55x55	Structure	Structure
TM3	127	K	3.56x56	Structure	AF2
ICL2	128	P	34.50x50	Structure	Structure
ICL2	129	L	34.51x51	Structure	Structure
ICL2	130	T	34.52x52	Structure	Structure
ICL2	131	Y	34.53x53	Structure	Structure
ICL2	132	P	34.54x54	Structure	Structure
ICL2	133	V	34.55x55	Structure	Structure
ICL2	134	K	34.56x56	Structure	Structure
ICL2	135	R	34.57x57	Structure	Structure
TM4	136	T	4.38x38	Structure	AF2
TM4	137	T	4.39x39	Structure	Structure
TM4	138	K	4.40x40	Structure	AF2
TM4	139	M	4.41x41	Structure	Structure
TM4	140	A	4.42x42	Structure	Structure
TM4	141	G	4.43x43	Structure	Structure
TM4	142	M	4.44x44	Structure	Structure
TM4	143	M	4.45x45	Structure	Structure
TM4	144	I	4.46x46	Structure	Structure
TM4	145	A	4.47x47	Structure	Structure
TM4	146	A	4.48x48	Structure	Structure
TM4	147	A	4.49x49	Structure	Structure
TM4	148	W	4.50x50	Structure	Structure
TM4	149	V	4.51x51	Structure	AF2
TM4	150	L	4.52x52	Structure	Structure
TM4	151	S	4.53x53	Structure	Structure
TM4	152	F	4.54x54	Structure	Structure
TM4	153	I	4.55x55	Structure	Structure
TM4	154	L	4.56x56	Structure	Structure
TM4	155	W	4.57x57	Structure	Structure
TM4	156	A	4.58x58	Structure	Structure
TM4	157	P	4.59x59	Structure	Structure
TM4	158	A	4.60x60	Structure	Structure
TM4	159	I	4.61x61	Structure	Structure
TM4	160	L	4.62x62	Structure	Structure
TM4	161	F	4.63x63	Structure	Structure
TM4	162	W	4.64x64	Structure	Structure
TM4	163	Q	4.65x65	Structure	Structure
TM4	164	F	4.66x66	Structure	Structure
TM4	165	I	4.67x67	Structure	Structure
TM4	166	V	4.68x68	Structure	Structure
TM4	167	G	4.69x69	Structure	Structure
ECL2	168	V	-	Structure	AF2
ECL2	169	R	-	Structure	Structure
ECL2	170	T	-	Structure	Structure
ECL2	171	V	-	Structure	Structure
ECL2	172	E	-	Structure	Structure
ECL2	173	D	-	Structure	AF2
ECL2	174	G	-	Structure	Structure
ECL2	175	E	-	Structure	AF2
ECL2	176	C	45.50x50	Structure	Structure
ECL2	177	Y	45.51x51	Structure	Structure
ECL2	178	I	45.52x52	Structure	Structure
ECL2	179	Q	-	Structure	Structure
ECL2	180	F	-	Structure	Structure
ECL2	181	F	-	Structure	AF2
ECL2	182	S	-	Structure	Structure
TM5	183	N	5.35x36	Structure	Structure
TM5	184	A	5.36x37	Structure	Structure
TM5	185	A	5.37x38	Structure	Structure
TM5	186	V	5.38x39	Structure	Structure
TM5	187	T	5.39x40	Structure	Structure
TM5	188	F	5.40x41	Structure	Structure
TM5	189	G	5.41x42	Structure	Structure
TM5	190	T	5.42x43	Structure	Structure
TM5	191	A	5.43x44	Structure	Structure
TM5	192	I	5.44x45	Structure	AF2
TM5	193	A	5.45x46	Structure	Structure
TM5	194	A	5.46x461	Structure	Structure
TM5	195	F	5.47x47	Structure	Structure
TM5	196	Y	5.48x48	Structure	Structure
TM5	197	L	5.49x49	Structure	AF2
TM5	198	P	5.50x50	Structure	Structure
TM5	199	V	5.51x51	Structure	Structure
TM5	200	I	5.52x52	Structure	Structure
TM5	201	I	5.53x53	Structure	Structure
TM5	202	M	5.54x54	Structure	Structure
TM5	203	T	5.55x55	Structure	Structure
TM5	204	V	5.56x56	Structure	Structure
TM5	205	L	5.57x57	Structure	Structure
TM5	206	Y	5.58x58	Structure	Structure
TM5	207	W	5.59x59	Structure	Structure
TM5	208	H	5.60x60	Structure	Structure
TM5	209	I	5.61x61	Structure	Structure
TM5	210	S	5.62x62	Structure	Structure
TM5	211	R	5.63x63	Structure	Structure
TM5	212	A	5.64x64	Structure	Structure
TM5	213	S	5.65x65	Structure	Structure
TM5	214	K	5.66x66	Structure	Structure
TM5	215	S	5.67x67	Structure	Structure
TM5	216	R	5.68x68	Structure	Structure
TM5	217	I	5.69x69	Structure	Structure
TM5	218	K	5.70x70	Structure	Structure
TM5	219	K	5.71x71	AF2	AF2
TM5	220	D	5.72x72	AF2	AF2
TM5	221	K	5.73x73	AF2	AF2
TM5	222	K	5.74x74	AF2	AF2
TM5	223	E	5.75x75	AF2	AF2
ICL3	224	P	-	AF2	AF2
ICL3	225	V	-	AF2	AF2
ICL3	226	A	-	AF2	AF2
ICL3	227	N	-	AF2	AF2
ICL3	228	Q	-	AF2	AF2
ICL3	229	D	-	AF2	AF2
ICL3	230	P	-	AF2	AF2
ICL3	369	T	-	AF2	AF2
ICL3	370	K	-	AF2	AF2
ICL3	371	Q	-	AF2	AF2
ICL3	372	P	-	AF2	AF2
ICL3	373	A	-	AF2	AF2
ICL3	374	K	-	AF2	AF2
ICL3	375	K	-	AF2	AF2
TM6	376	K	6.24x24	AF2	AF2
TM6	377	P	6.25x25	AF2	AF2
TM6	378	P	6.26x26	AF2	AF2
TM6	379	P	6.27x27	Structure	Structure
TM6	380	S	6.28x28	Structure	Structure
TM6	381	R	6.29x29	Structure	Structure
TM6	382	E	6.30x30	Structure	AF2
TM6	383	K	6.31x31	Structure	Structure
TM6	384	K	6.32x32	Structure	Structure
TM6	385	V	6.33x33	Structure	Structure
TM6	386	T	6.34x34	Structure	Structure
TM6	387	R	6.35x35	Structure	Structure
TM6	388	T	6.36x36	Structure	Structure
TM6	389	I	6.37x37	Structure	Structure
TM6	390	L	6.38x38	Structure	Structure
TM6	391	A	6.39x39	Structure	Structure
TM6	392	I	6.40x40	Structure	Structure
TM6	393	L	6.41x41	Structure	Structure
TM6	394	L	6.42x42	Structure	Structure
TM6	395	A	6.43x43	Structure	Structure
TM6	396	F	6.44x44	Structure	Structure
TM6	397	I	6.45x45	Structure	Structure
TM6	398	I	6.46x46	Structure	Structure
TM6	399	T	6.47x47	Structure	Structure
TM6	400	W	6.48x48	Structure	Structure
TM6	401	A	6.49x49	Structure	Structure
TM6	402	P	6.50x50	Structure	Structure
TM6	403	Y	6.51x51	Structure	Structure
TM6	404	N	6.52x52	Structure	Structure
TM6	405	V	6.53x53	Structure	Structure
TM6	406	M	6.54x54	Structure	Structure
TM6	407	V	6.55x55	Structure	Structure
TM6	408	L	6.56x56	Structure	Structure
TM6	409	I	6.57x57	Structure	Structure
TM6	410	N	6.58x58	Structure	Structure
TM6	411	T	6.59x59	Structure	Structure
TM6	412	F	6.60x60	Structure	Structure
TM6	413	C	6.61x61	Structure	Structure
ECL3	414	A	-	Structure	Structure
ECL3	415	P	-	Structure	Structure
ECL3	416	C	-	Structure	Structure
ECL3	417	I	-	Structure	Structure
TM7	418	P	7.31x30	Structure	Structure
TM7	419	N	7.32x31	Structure	Structure
TM7	420	T	7.33x32	Structure	AF2
TM7	421	V	7.34x33	Structure	AF2
TM7	422	W	7.35x34	Structure	Structure
TM7	423	T	7.36x35	Structure	Structure
TM7	424	I	7.37x36	Structure	AF2
TM7	425	G	7.38x37	Structure	Structure
TM7	426	Y	7.39x38	Structure	Structure
TM7	427	W	7.40x39	Structure	Structure
TM7	428	L	7.41x40	Structure	Structure
TM7	429	C	7.42x41	Structure	Structure
TM7	430	Y	7.43x42	Structure	Structure
TM7	431	I	7.44x43	Structure	Structure
TM7	432	N	7.45x45	Structure	Structure
TM7	433	S	7.46x46	Structure	Structure
TM7	434	T	7.47x47	Structure	Structure
TM7	435	I	7.48x48	Structure	Structure
TM7	436	N	7.49x49	Structure	Structure
TM7	437	P	7.50x50	Structure	Structure
TM7	438	A	7.51x51	Structure	Structure
TM7	439	C	7.52x52	Structure	Structure
TM7	440	Y	7.53x53	Structure	Structure
TM7	441	A	7.54x54	Structure	Structure
TM7	442	L	7.55x55	Structure	Structure
TM7	443	C	7.56x56	Structure	Structure
H8	444	N	8.47x47	Structure	Structure
H8	445	A	8.48x48	Structure	Structure
H8	446	T	8.49x49	Structure	Structure
H8	447	F	8.50x50	Structure	Structure
H8	448	K	8.51x51	Structure	AF2
H8	449	K	8.52x52	Structure	AF2
H8	450	T	8.53x53	Structure	Structure
H8	451	F	8.54x54	Structure	Structure
H8	452	K	8.55x55	Structure	AF2
H8	453	H	8.56x56	Structure	Structure
H8	454	L	8.57x57	Structure	Structure
H8	455	L	8.58x58	Structure	Structure
H8	456	M	8.59x59	Structure	Structure
C-term	457	C	-	Structure	Structure
C-term	458	H	-	AF2	AF2
C-term	459	Y	-	AF2	AF2
C-term	460	K	-	AF2	AF2
C-term	461	N	-	AF2	AF2
C-term	462	I	-	AF2	AF2
C-term	463	G	-	AF2	AF2
C-term	464	A	-	AF2	AF2
C-term	465	T	-	AF2	AF2
C-term	466	R	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM6	R	381	6x29	G.H5	D	341	G.H5.13
Hydrophobic	ICL2	V	133	34x55	G.hns1	K	32	G.hns1.03
Hydrophobic	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM6	V	385	6x33	G.H5	Y	354	G.H5.26
Hydrophobic	TM5	I	217	5x69	G.S6	Y	320	G.S6.02
Hydrophobic	TM2	N	58	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM5	I	217	5x69	G.H5	A	338	G.H5.10
Hydrophobic	TM5	I	209	5x61	G.H5	L	353	G.H5.25
Hydrophobic	H8	N	444	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM6	I	392	6x40	G.H5	L	353	G.H5.25
Hydrophobic	TM5	I	217	5x69	G.H5	D	341	G.H5.13
Hydrophobic	TM3	V	125	3x54	G.H5	L	348	G.H5.20
Hydrophobic	TM6	R	381	6x29	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	Q	228	-	G.hgh4	T	292	G.hgh4.06
Hydrophobic	TM6	R	381	6x29	G.H5	I	344	G.H5.16
Hydrophobic	TM6	R	381	6x29	G.H5	Y	354	G.H5.26
Hydrophobic	TM6	V	385	6x33	G.H5	L	348	G.H5.20
Hydrophobic	TM6	I	389	6x37	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	L	129	34x51	G.S3	L	195	G.S3.01
Hydrophobic	TM5	S	213	5x65	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	P	128	34x50	G.H5	I	344	G.H5.16
Hydrophobic	TM6	K	384	6x32	G.H5	Y	354	G.H5.26
Hydrophobic	TM3	R	121	3x50	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	P	128	34x50	G.H5	I	343	G.H5.15
Hydrophobic	TM5	I	217	5x69	G.H5	D	337	G.H5.09
Hydrophobic	TM6	P	378	6x26	G.h4s6	P	315	G.h4s6.09
Ionic	TM6	R	381	6x29	G.H5	D	341	G.H5.13
Ionic	TM5	K	222	5x74	G.H4	E	298	G.H4.04
Polar	TM6	R	381	6x29	G.H5	D	341	G.H5.13
Polar	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Polar	TM5	R	216	5x68	G.H5	D	341	G.H5.13
Polar	ICL3	Q	228	-	G.hgh4	T	292	G.hgh4.06
Polar	TM6	R	381	6x29	G.H5	Y	354	G.H5.26
Polar	TM7	C	443	7x56	G.H5	G	352	G.H5.24
Polar	TM6	T	388	6x36	G.H5	L	353	G.H5.25
Polar	TM5	S	215	5x67	G.H5	D	341	G.H5.13
Van-der-waals	TM6	R	381	6x29	G.H5	D	341	G.H5.13
Van-der-waals	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Van-der-waals	TM5	I	217	5x69	G.S6	Y	320	G.S6.02
Van-der-waals	TM5	I	217	5x69	G.H5	A	338	G.H5.10
Van-der-waals	TM5	I	217	5x69	G.H5	D	341	G.H5.13
Van-der-waals	TM6	R	381	6x29	G.H5	L	348	G.H5.20
Van-der-waals	ICL3	Q	228	-	G.hgh4	T	292	G.hgh4.06
Van-der-waals	TM6	R	381	6x29	G.H5	I	344	G.H5.16
Van-der-waals	TM6	R	381	6x29	G.H5	Y	354	G.H5.26
Van-der-waals	TM7	C	443	7x56	G.H5	G	352	G.H5.24
Van-der-waals	TM6	T	388	6x36	G.H5	L	353	G.H5.25
Van-der-waals	ICL2	P	128	34x50	G.H5	I	344	G.H5.16
Van-der-waals	TM5	S	215	5x67	G.H5	D	341	G.H5.13

Showing 1 to 49 of 49 entries

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Main reference

Refined structure (6OIK) of Go - M2 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (6OIK) of G_o - M₂ receptor

Full