M2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

May 8, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

iperoxo - Agonist pubchem gtoplig chembl_ligand ,

LY2119620 - Ago-PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL3 S 380 - G.H5 Y 354 G.H5.26
Ionic ICL3 R 381 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 129 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 R 121 3x50 G.H5 L 353 G.H5.25
Van-der-waals ICL3 S 215 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 381 - G.H5 I 344 G.H5.16
Polar TM6 T 388 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 388 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 I 217 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 381 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 R 381 - G.H5 L 348 G.H5.20
Hydrophobic TM5 S 213 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 392 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 385 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 385 6x33 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 133 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 K 384 6x32 G.H5 Y 354 G.H5.26
Polar TM7 C 443 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 C 443 7x56 G.H5 G 352 G.H5.24
Polar ICL3 R 381 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 R 381 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 R 381 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 I 217 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 389 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 N 58 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 209 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic H8 N 444 8x47 G.H5 G 352 G.H5.24