NK3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JBF

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41421-023-00564-W

PUBLICATION DATE

Feb. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

72 interactions (Click to see)

LIGANDS

senktide - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

substance P, neurokinin A, neurokinin B



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 191 - G.H5 C 346 G.H5.11
Hydrophobic ICL2 P 190 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 190 - G.H5 I 350 G.H5.15
Hydrophobic TM6 M 301 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM2 T 120 2x39 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 191 - G.H5 K 347 G.H5.12
Van-der-waals TM2 N 121 2x40 G.H5 N 359 G.H5.24
Hydrophobic TM6 K 294 6x30 G.H5 L 355 G.H5.20
Hydrophobic ICL2 L 191 - G.S1 L 34 G.S1.02
Hydrophobic TM5 L 274 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM3 R 183 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 193 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 183 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 183 3x50 G.H5 L 360 G.H5.25
Ionic TM6 K 294 6x30 G.H5 D 348 G.H5.13
Polar TM6 K 294 6x30 G.H5 D 348 G.H5.13
Hydrophobic ICL4 N 360 - G.H5 N 359 G.H5.24
Van-der-waals ICL4 N 360 - G.H5 N 359 G.H5.24
Polar TM2 T 120 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 120 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 120 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM6 Q 290 6x26 G.h4s6 I 325 G.h4s6.20
Hydrophobic TM7 L 359 7x56 G.H5 V 361 G.H5.26
Van-der-waals TM7 L 359 7x56 G.H5 V 361 G.H5.26
Van-der-waals TM6 K 294 6x30 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 P 193 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 193 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 186 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM6 A 293 6x29 G.H5 V 361 G.H5.26
Polar TM3 D 182 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 182 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 182 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 190 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 P 190 - G.H5 K 347 G.H5.12
Polar TM6 K 296 6x32 G.H5 V 361 G.H5.26
Hydrophobic ICL2 L 191 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 191 - G.H5 F 343 G.H5.08
Polar TM6 Q 290 6x26 G.H5 Q 352 G.H5.17
Hydrophobic ICL2 L 191 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 191 - G.H5 I 350 G.H5.15
Hydrophobic TM3 I 187 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 187 3x54 G.H5 L 355 G.H5.20
Polar ICL2 R 194 - G.H5 Y 358 G.H5.23
Hydrophobic ICL2 R 194 - G.H5 Y 358 G.H5.23
Van-der-waals ICL2 R 194 - G.H5 Y 358 G.H5.23
Hydrophobic TM6 V 297 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 297 6x33 G.H5 L 360 G.H5.25
Polar TM3 A 186 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM5 L 274 5x65 G.H5 L 351 G.H5.16
Polar ICL2 P 190 - G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 190 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 P 190 - G.H5 L 351 G.H5.16
Hydrophobic H8 F 363 8x50 G.H5 N 359 G.H5.24
Hydrophobic TM6 M 300 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 M 300 6x36 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 191 - G.S3 V 194 G.S3.01
Hydrophobic TM6 K 294 6x30 G.H5 L 351 G.H5.16
Hydrophobic TM3 I 187 3x54 G.H5 L 351 G.H5.16