Refined structure (6LML) of Gi1 - glucagon receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 224 from structure (63.3%), 130 from model (36.7%)
Residue sidechains - 200 from structure (56.5%), 154 from model (43.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure AF2
G.s4h3 237 D G.s4h3.11 Structure AF2
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure AF2
G.s4h3 240 M G.s4h3.14 Structure AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure AF2
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 395 from structure (90.0%), 44 from model (10.0%)
Residue sidechains - 376 from structure (85.6%), 63 from model (14.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 C - AF2 AF2
N-term 5 Q - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 C - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 Q - AF2 AF2
N-term 23 V - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 Q - Structure Structure
N-term 28 V - Structure Structure
N-term 29 M - Structure Structure
N-term 30 D - Structure Structure
N-term 31 F - Structure Structure
N-term 32 L - Structure Structure
N-term 33 F - Structure Structure
N-term 34 E - Structure Structure
N-term 35 K - Structure Structure
N-term 36 W - Structure Structure
N-term 37 K - Structure Structure
N-term 38 L - Structure Structure
N-term 39 Y - Structure Structure
N-term 40 G - Structure Structure
N-term 41 D - Structure Structure
N-term 42 Q - Structure Structure
N-term 43 C - Structure Structure
N-term 44 H - Structure Structure
N-term 45 H - Structure Structure
N-term 46 N - Structure Structure
N-term 47 L - Structure Structure
N-term 48 S - Structure Structure
N-term 49 L - Structure Structure
N-term 50 L - Structure Structure
N-term 51 P - Structure Structure
N-term 52 P - Structure Structure
N-term 53 P - Structure AF2
N-term 54 T - Structure AF2
N-term 55 E - Structure AF2
N-term 56 L - Structure Structure
N-term 57 V - Structure Structure
N-term 58 C - Structure Structure
N-term 59 N - Structure Structure
N-term 60 R - Structure Structure
N-term 61 T - Structure Structure
N-term 62 F - Structure Structure
N-term 63 D - Structure Structure
N-term 64 K - Structure Structure
N-term 65 Y - Structure Structure
N-term 66 S - Structure Structure
N-term 67 C - Structure Structure
N-term 68 W - Structure Structure
N-term 69 P - Structure Structure
N-term 70 D - Structure Structure
N-term 71 T - Structure Structure
N-term 72 P - Structure Structure
N-term 73 A - Structure Structure
N-term 74 N - Structure Structure
N-term 75 T - Structure Structure
N-term 76 T - Structure Structure
N-term 77 A - Structure Structure
N-term 78 N - Structure Structure
N-term 79 I - Structure Structure
N-term 80 S - Structure Structure
N-term 81 C - Structure Structure
N-term 82 P - Structure Structure
N-term 83 W - Structure Structure
N-term 84 Y - Structure Structure
N-term 85 L - Structure Structure
N-term 86 P - Structure Structure
N-term 87 W - Structure Structure
N-term 88 H - Structure Structure
N-term 89 H - Structure Structure
N-term 90 K - Structure Structure
N-term 91 V - Structure Structure
N-term 92 Q - Structure Structure
N-term 93 H - Structure Structure
N-term 94 R - Structure Structure
N-term 95 F - Structure Structure
N-term 96 V - Structure Structure
N-term 97 F - Structure Structure
N-term 98 K - Structure Structure
N-term 99 R - Structure Structure
N-term 100 C - Structure Structure
N-term 101 G - Structure Structure
N-term 102 P - Structure Structure
N-term 103 D - Structure Structure
N-term 104 G - Structure Structure
N-term 105 Q - Structure Structure
N-term 106 W - Structure Structure
N-term 107 V - Structure Structure
N-term 108 R - Structure Structure
N-term 109 G - Structure Structure
N-term 110 P - Structure Structure
N-term 111 R - Structure Structure
N-term 112 G - Structure Structure
N-term 113 Q - Structure Structure
N-term 114 P - Structure Structure
N-term 115 W - Structure Structure
N-term 116 R - Structure AF2
N-term 117 D - Structure Structure
N-term 118 A - Structure Structure
N-term 119 S - Structure Structure
N-term 120 Q - Structure Structure
N-term 121 C - Structure Structure
N-term 122 Q - Structure Structure
N-term 123 M - Structure Structure
N-term 124 D - Structure Structure
N-term 125 G - Structure Structure
N-term 126 E - Structure AF2
N-term 127 E - Structure Structure
N-term 128 I - Structure Structure
N-term 129 E - Structure Structure
N-term 130 V - Structure Structure
TM1 131 Q 1.29x29 Structure Structure
TM1 132 K 1.30x30 Structure Structure
TM1 133 E 1.31x31 Structure Structure
TM1 134 V 1.32x32 Structure Structure
TM1 135 A 1.33x33 Structure Structure
TM1 136 K 1.34x34 Structure Structure
TM1 137 M 1.35x35 Structure Structure
TM1 138 Y 1.36x36 Structure Structure
TM1 139 S 1.37x37 Structure Structure
TM1 140 S 1.38x38 Structure Structure
TM1 141 F 1.39x39 Structure Structure
TM1 142 Q 1.40x40 Structure Structure
TM1 143 V 1.41x41 Structure Structure
TM1 144 M 1.42x42 Structure Structure
TM1 145 Y 1.43x43 Structure Structure
TM1 146 T 1.44x44 Structure Structure
TM1 147 V 1.45x45 Structure Structure
TM1 148 G 1.46x46 Structure Structure
TM1 149 Y 1.47x47 Structure Structure
TM1 150 S 1.48x48 Structure Structure
TM1 151 L 1.49x49 Structure Structure
TM1 152 S 1.50x50 Structure Structure
TM1 153 L 1.51x51 Structure Structure
TM1 154 G 1.52x52 Structure Structure
TM1 155 A 1.53x53 Structure Structure
TM1 156 L 1.54x54 Structure Structure
TM1 157 L 1.55x55 Structure Structure
TM1 158 L 1.56x56 Structure Structure
TM1 159 A 1.57x57 Structure Structure
TM1 160 L 1.58x58 Structure Structure
TM1 161 A 1.59x59 Structure Structure
TM1 162 I 1.60x60 Structure Structure
TM1 163 L 1.61x61 Structure Structure
TM1 164 G 1.62x62 Structure Structure
TM1 165 G 1.63x63 Structure Structure
TM1 166 L 1.64x64 Structure Structure
ICL1 167 S 12.48x48 Structure Structure
ICL1 168 K 12.49x49 Structure Structure
ICL1 169 L 12.50x50 Structure Structure
ICL1 170 H 12.51x51 Structure Structure
TM2 171 C 2.44x44 Structure Structure
TM2 172 T 2.45x45 Structure Structure
TM2 173 R 2.46x46 Structure Structure
TM2 174 N 2.47x47 Structure Structure
TM2 175 A 2.48x48 Structure Structure
TM2 176 I 2.49x49 Structure Structure
TM2 177 H 2.50x50 Structure Structure
TM2 178 A 2.51x51 Structure Structure
TM2 179 N 2.52x52 Structure Structure
TM2 180 L 2.53x53 Structure Structure
TM2 181 F 2.54x54 Structure Structure
TM2 182 A 2.55x55 Structure Structure
TM2 183 S 2.56x56 Structure Structure
TM2 184 F 2.57x57 Structure Structure
TM2 185 V 2.58x58 Structure Structure
TM2 186 L 2.59x59 Structure Structure
TM2 187 K 2.60x60 Structure Structure
TM2 188 A 2.61x61 Structure Structure
TM2 189 S 2.62x62 Structure Structure
TM2 190 S 2.63x63 Structure Structure
TM2 191 V 2.64x64 Structure Structure
TM2 192 L 2.65x65 Structure Structure
TM2 193 V 2.66x66 Structure Structure
TM2 194 I 2.67x67 Structure Structure
TM2 195 D 2.68x68 Structure Structure
TM2 196 G 2.69x69 Structure Structure
TM2 197 L 2.70x70 Structure Structure
TM2 198 L 2.71x71 Structure Structure
TM2 199 R 2.72x72 Structure Structure
TM2 200 T 2.73x73 Structure AF2
TM2 201 R 2.74x74 Structure Structure
TM2 202 Y 2.75x75 Structure Structure
TM2 203 S 2.76x76 Structure Structure
ECL1 204 Q - Structure Structure
ECL1 205 K - Structure AF2
ECL1 206 I - Structure Structure
ECL1 207 G - Structure Structure
ECL1 208 D - Structure AF2
ECL1 209 D - Structure Structure
ECL1 210 L - Structure Structure
ECL1 211 S - Structure Structure
ECL1 212 V - Structure Structure
ECL1 213 S - Structure Structure
ECL1 214 T - Structure Structure
ECL1 215 W - Structure Structure
ECL1 216 L - Structure Structure
ECL1 217 S - Structure Structure
ECL1 218 D - Structure AF2
ECL1 219 G - Structure Structure
TM3 220 A 3.25x25 Structure Structure
TM3 221 V 3.26x26 Structure Structure
TM3 222 A 3.27x27 Structure Structure
TM3 223 G 3.28x28 Structure Structure
TM3 224 C 3.29x29 Structure Structure
TM3 225 R 3.30x30 Structure Structure
TM3 226 V 3.31x31 Structure Structure
TM3 227 A 3.32x32 Structure Structure
TM3 228 A 3.33x33 Structure Structure
TM3 229 V 3.34x34 Structure Structure
TM3 230 F 3.35x35 Structure Structure
TM3 231 M 3.36x36 Structure Structure
TM3 232 Q 3.37x37 Structure Structure
TM3 233 Y 3.38x38 Structure Structure
TM3 234 G 3.39x39 Structure Structure
TM3 235 I 3.40x40 Structure Structure
TM3 236 V 3.41x41 Structure Structure
TM3 237 A 3.42x42 Structure Structure
TM3 238 N 3.43x43 Structure Structure
TM3 239 Y 3.44x44 Structure Structure
TM3 240 C 3.45x45 Structure Structure
TM3 241 W 3.46x46 Structure Structure
TM3 242 L 3.47x47 Structure Structure
TM3 243 L 3.48x48 Structure Structure
TM3 244 V 3.49x49 Structure Structure
TM3 245 E 3.50x50 Structure Structure
TM3 246 G 3.51x51 Structure Structure
TM3 247 L 3.52x52 Structure Structure
TM3 248 Y 3.53x53 Structure Structure
TM3 249 L 3.54x54 Structure Structure
TM3 250 H 3.55x55 Structure Structure
TM3 251 N 3.56x56 Structure Structure
TM3 252 L 3.57x57 Structure Structure
TM3 253 L 3.58x58 Structure Structure
TM3 254 G 3.59x59 Structure Structure
TM3 255 L 3.60x60 Structure Structure
ICL2 256 A - Structure Structure
ICL2 257 T - Structure Structure
ICL2 258 L - Structure Structure
ICL2 259 P - Structure Structure
ICL2 260 E - Structure Structure
ICL2 261 R - Structure Structure
TM4 262 S 4.40x41 Structure Structure
TM4 263 F 4.41x42 Structure Structure
TM4 264 F 4.42x43 Structure Structure
TM4 265 S 4.43x44 Structure Structure
TM4 266 L 4.44x45 Structure Structure
TM4 267 Y 4.45x46 Structure Structure
TM4 268 L 4.46x47 Structure Structure
TM4 269 G 4.47x48 Structure Structure
TM4 270 I 4.48x49 Structure Structure
TM4 271 G 4.49x491 Structure Structure
TM4 272 W 4.50x50 Structure Structure
TM4 273 G 4.51x51 Structure Structure
TM4 274 A 4.52x52 Structure Structure
TM4 275 P 4.53x53 Structure Structure
TM4 276 M 4.54x54 Structure Structure
TM4 277 L 4.55x55 Structure Structure
TM4 278 F 4.56x56 Structure Structure
TM4 279 V 4.57x57 Structure Structure
TM4 280 V 4.58x58 Structure Structure
TM4 281 P 4.59x59 Structure Structure
TM4 282 W 4.60x60 Structure Structure
TM4 283 A 4.61x61 Structure Structure
TM4 284 V 4.62x62 Structure Structure
TM4 285 V 4.63x63 Structure Structure
TM4 286 K 4.64x64 Structure Structure
TM4 287 C 4.65x65 Structure Structure
TM4 288 L 4.66x66 Structure Structure
TM4 289 F 4.67x67 Structure Structure
TM4 290 E 4.68x68 Structure Structure
ECL2 291 N - Structure Structure
ECL2 292 V - Structure Structure
ECL2 293 Q - Structure Structure
ECL2 294 C 45.50x50 Structure Structure
ECL2 295 W 45.51x51 Structure Structure
ECL2 296 T 45.52x52 Structure Structure
ECL2 297 S - Structure Structure
ECL2 298 N - Structure Structure
ECL2 299 D - Structure Structure
ECL2 300 N - Structure Structure
ECL2 301 M - Structure AF2
ECL2 302 G - Structure Structure
ECL2 303 F - Structure AF2
TM5 304 W 5.36x37 Structure Structure
TM5 305 W 5.37x38 Structure Structure
TM5 306 I 5.38x381 Structure Structure
TM5 307 L 5.39x39 Structure Structure
TM5 308 R 5.40x40 Structure Structure
TM5 309 F 5.41x41 Structure Structure
TM5 310 P 5.42x42 Structure Structure
TM5 311 V 5.43x43 Structure Structure
TM5 312 F 5.44x44 Structure Structure
TM5 313 L 5.45x45 Structure Structure
TM5 314 A 5.46x46 Structure Structure
TM5 315 I 5.47x47 Structure Structure
TM5 316 L 5.48x48 Structure Structure
TM5 317 I 5.49x49 Structure Structure
TM5 318 N 5.50x50 Structure Structure
TM5 319 F 5.51x51 Structure Structure
TM5 320 F 5.52x52 Structure Structure
TM5 321 I 5.53x53 Structure Structure
TM5 322 F 5.54x54 Structure Structure
TM5 323 V 5.55x55 Structure Structure
TM5 324 R 5.56x56 Structure Structure
TM5 325 I 5.57x57 Structure Structure
TM5 326 V 5.58x58 Structure Structure
TM5 327 Q 5.59x59 Structure Structure
TM5 328 L 5.60x60 Structure Structure
TM5 329 L 5.61x61 Structure Structure
TM5 330 V 5.62x62 Structure Structure
TM5 331 A 5.63x63 Structure Structure
TM5 332 K 5.64x64 Structure Structure
TM5 333 L 5.65x65 Structure Structure
TM5 334 R 5.66x66 Structure Structure
TM5 335 A 5.67x67 Structure Structure
ICL3 336 R - Structure Structure
ICL3 337 Q - Structure AF2
ICL3 338 M - Structure AF2
ICL3 339 H - Structure Structure
ICL3 340 H - Structure AF2
ICL3 341 T - Structure AF2
TM6 342 D 6.33x33 Structure AF2
TM6 343 Y 6.34x34 Structure Structure
TM6 344 K 6.35x35 Structure Structure
TM6 345 F 6.36x36 Structure Structure
TM6 346 R 6.37x37 Structure Structure
TM6 347 L 6.38x38 Structure Structure
TM6 348 A 6.39x39 Structure Structure
TM6 349 K 6.40x40 Structure Structure
TM6 350 S 6.41x41 Structure Structure
TM6 351 T 6.42x42 Structure Structure
TM6 352 L 6.43x43 Structure Structure
TM6 353 T 6.44x44 Structure Structure
TM6 354 L 6.45x45 Structure Structure
TM6 355 I 6.46x46 Structure Structure
TM6 356 P 6.47x47 Structure Structure
TM6 357 L 6.48x48 Structure Structure
TM6 358 L 6.49x49 Structure Structure
TM6 359 G 6.50x50 Structure Structure
TM6 360 V 6.51x51 Structure Structure
TM6 361 H 6.52x52 Structure Structure
TM6 362 E 6.53x53 Structure AF2
TM6 363 V 6.54x54 Structure Structure
TM6 364 V 6.55x55 Structure Structure
TM6 365 F 6.56x56 Structure Structure
TM6 366 A 6.57x57 Structure AF2
TM6 367 F 6.58x58 Structure AF2
TM6 368 V 6.59x59 Structure Structure
TM6 369 T 6.60x60 Structure Structure
TM6 370 D 6.61x61 Structure Structure
ECL3 371 E - Structure Structure
ECL3 372 H - Structure Structure
ECL3 373 A - Structure Structure
ECL3 374 Q - Structure Structure
TM7 375 G 7.32x31 Structure Structure
TM7 376 T 7.33x32 Structure Structure
TM7 377 L 7.34x33 Structure Structure
TM7 378 R 7.35x34 Structure Structure
TM7 379 S 7.36x35 Structure Structure
TM7 380 A 7.37x36 Structure Structure
TM7 381 K 7.38x37 Structure Structure
TM7 382 L 7.39x38 Structure Structure
TM7 383 F 7.40x39 Structure Structure
TM7 384 F 7.41x40 Structure Structure
TM7 385 D 7.42x41 Structure Structure
TM7 386 L 7.43x42 Structure Structure
TM7 387 F 7.44x43 Structure Structure
TM7 388 L 7.45x44 Structure Structure
TM7 389 S 7.46x45 Structure Structure
TM7 390 S 7.47x46 Structure Structure
TM7 391 F 7.48x47 Structure Structure
TM7 392 Q 7.49x49 Structure Structure
TM7 393 G 7.50x50 Structure Structure
TM7 394 L 7.51x51 Structure Structure
TM7 395 L 7.52x52 Structure Structure
TM7 396 V 7.53x53 Structure Structure
TM7 397 A 7.54x54 Structure Structure
TM7 398 V 7.55x55 Structure Structure
TM7 399 L 7.56x56 Structure Structure
TM7 400 Y 7.57x57 Structure Structure
TM7 401 C 7.58x58 Structure Structure
TM7 402 F 7.59x59 Structure Structure
TM7 403 L 7.60x60 Structure Structure
H8 404 N 8.47x47 Structure Structure
H8 405 K 8.48x48 Structure Structure
H8 406 E 8.49x49 Structure Structure
H8 407 V 8.50x50 Structure Structure
H8 408 Q 8.51x51 Structure Structure
H8 409 S 8.52x52 Structure Structure
H8 410 E 8.53x53 Structure Structure
H8 411 L 8.54x54 Structure Structure
H8 412 R 8.55x55 Structure Structure
H8 413 R 8.56x56 Structure Structure
H8 414 R 8.57x57 Structure Structure
H8 415 W 8.58x58 Structure Structure
H8 416 H 8.59x59 Structure Structure
H8 417 R 8.60x60 Structure Structure
H8 418 W 8.61x61 Structure Structure
H8 419 R 8.62x62 Structure Structure
H8 420 L 8.63x63 Structure Structure
H8 421 G 8.64x64 Structure Structure
H8 422 K 8.65x65 AF2 AF2
H8 423 V 8.66x66 AF2 AF2
H8 424 L 8.67x67 AF2 AF2
H8 425 W 8.68x68 AF2 AF2
H8 426 E 8.69x69 AF2 AF2
H8 427 E 8.70x70 AF2 AF2
H8 428 R 8.71x71 AF2 AF2
H8 429 N 8.72x72 AF2 AF2
C-term 430 T - AF2 AF2
C-term 431 S - AF2 AF2
C-term 432 N - AF2 AF2
C-term 433 H - AF2 AF2
C-term 434 R - AF2 AF2
C-term 435 A - AF2 AF2
C-term 436 S - AF2 AF2
C-term 437 S - AF2 AF2
C-term 438 S - AF2 AF2
C-term 439 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 E 260 - G.S1 L 39 G.S1.07
Van-der-waals ICL2 E 260 - G.S1 L 39 G.S1.07
Polar ICL3 H 339 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 H 339 - G.H5 D 350 G.H5.22
Van-der-waals ICL3 H 339 - G.H5 D 350 G.H5.22
Polar ICL2 L 258 - G.S1 L 38 G.S1.06
Hydrophobic ICL2 L 258 - G.S1 L 38 G.S1.06
Van-der-waals ICL2 L 258 - G.S1 L 38 G.S1.06
Polar ICL2 A 256 - G.s1h1 A 41 G.s1h1.02
Hydrophobic ICL2 A 256 - G.s1h1 A 41 G.s1h1.02
Van-der-waals ICL2 A 256 - G.s1h1 A 41 G.s1h1.02
Hydrophobic ICL2 R 261 - G.S1 K 35 G.S1.03
Van-der-waals ICL2 R 261 - G.S1 K 35 G.S1.03
Hydrophobic ICL2 T 257 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 T 257 - G.h2s4 G 217 G.h2s4.03
Hydrophobic ICL2 E 260 - G.S1 K 35 G.S1.03
Hydrophobic ICL2 A 256 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 A 256 - G.h2s4 G 217 G.h2s4.03
Hydrophobic ICL2 T 257 - G.S1 L 39 G.S1.07
Hydrophobic ICL2 T 257 - G.s1h1 A 41 G.s1h1.02
Van-der-waals ICL2 T 257 - G.s1h1 A 41 G.s1h1.02