GPCRdb

Refined structure (6LML) of G_i1 - glucagon receptor

Full

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 224 from structure (63.3%), 130 from model (36.7%)
Residue sidechains - 200 from structure (56.5%), 154 from model (43.5%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	AF2
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	AF2
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	AF2
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	AF2
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	Structure	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	AF2
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	AF2
G.s4h3	233	V	G.s4h3.07	Structure	Structure
G.s4h3	234	L	G.s4h3.08	Structure	Structure
G.s4h3	235	A	G.s4h3.09	Structure	Structure
G.s4h3	236	E	G.s4h3.10	Structure	AF2
G.s4h3	237	D	G.s4h3.11	Structure	AF2
G.s4h3	238	E	G.s4h3.12	Structure	AF2
G.s4h3	239	E	G.s4h3.13	Structure	AF2
G.s4h3	240	M	G.s4h3.14	Structure	AF2
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	AF2
G.H3	248	K	G.H3.07	Structure	AF2
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	AF2
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	Structure
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	AF2
G.s6h5	328	D	G.s6h5.05	Structure	AF2
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 395 from structure (90.0%), 44 from model (10.0%)
Residue sidechains - 376 from structure (85.6%), 63 from model (14.4%)

Showing 1 to 439 of 439 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	P	-	AF2	AF2
N-term	3	P	-	AF2	AF2
N-term	4	C	-	AF2	AF2
N-term	5	Q	-	AF2	AF2
N-term	6	P	-	AF2	AF2
N-term	7	Q	-	AF2	AF2
N-term	8	R	-	AF2	AF2
N-term	9	P	-	AF2	AF2
N-term	10	L	-	AF2	AF2
N-term	11	L	-	AF2	AF2
N-term	12	L	-	AF2	AF2
N-term	13	L	-	AF2	AF2
N-term	14	L	-	AF2	AF2
N-term	15	L	-	AF2	AF2
N-term	16	L	-	AF2	AF2
N-term	17	L	-	AF2	AF2
N-term	18	A	-	AF2	AF2
N-term	19	C	-	AF2	AF2
N-term	20	Q	-	AF2	AF2
N-term	21	P	-	AF2	AF2
N-term	22	Q	-	AF2	AF2
N-term	23	V	-	AF2	AF2
N-term	24	P	-	AF2	AF2
N-term	25	S	-	AF2	AF2
N-term	26	A	-	AF2	AF2
N-term	27	Q	-	Structure	Structure
N-term	28	V	-	Structure	Structure
N-term	29	M	-	Structure	Structure
N-term	30	D	-	Structure	Structure
N-term	31	F	-	Structure	Structure
N-term	32	L	-	Structure	Structure
N-term	33	F	-	Structure	Structure
N-term	34	E	-	Structure	Structure
N-term	35	K	-	Structure	Structure
N-term	36	W	-	Structure	Structure
N-term	37	K	-	Structure	Structure
N-term	38	L	-	Structure	Structure
N-term	39	Y	-	Structure	Structure
N-term	40	G	-	Structure	Structure
N-term	41	D	-	Structure	Structure
N-term	42	Q	-	Structure	Structure
N-term	43	C	-	Structure	Structure
N-term	44	H	-	Structure	Structure
N-term	45	H	-	Structure	Structure
N-term	46	N	-	Structure	Structure
N-term	47	L	-	Structure	Structure
N-term	48	S	-	Structure	Structure
N-term	49	L	-	Structure	Structure
N-term	50	L	-	Structure	Structure
N-term	51	P	-	Structure	Structure
N-term	52	P	-	Structure	Structure
N-term	53	P	-	Structure	AF2
N-term	54	T	-	Structure	AF2
N-term	55	E	-	Structure	AF2
N-term	56	L	-	Structure	Structure
N-term	57	V	-	Structure	Structure
N-term	58	C	-	Structure	Structure
N-term	59	N	-	Structure	Structure
N-term	60	R	-	Structure	Structure
N-term	61	T	-	Structure	Structure
N-term	62	F	-	Structure	Structure
N-term	63	D	-	Structure	Structure
N-term	64	K	-	Structure	Structure
N-term	65	Y	-	Structure	Structure
N-term	66	S	-	Structure	Structure
N-term	67	C	-	Structure	Structure
N-term	68	W	-	Structure	Structure
N-term	69	P	-	Structure	Structure
N-term	70	D	-	Structure	Structure
N-term	71	T	-	Structure	Structure
N-term	72	P	-	Structure	Structure
N-term	73	A	-	Structure	Structure
N-term	74	N	-	Structure	Structure
N-term	75	T	-	Structure	Structure
N-term	76	T	-	Structure	Structure
N-term	77	A	-	Structure	Structure
N-term	78	N	-	Structure	Structure
N-term	79	I	-	Structure	Structure
N-term	80	S	-	Structure	Structure
N-term	81	C	-	Structure	Structure
N-term	82	P	-	Structure	Structure
N-term	83	W	-	Structure	Structure
N-term	84	Y	-	Structure	Structure
N-term	85	L	-	Structure	Structure
N-term	86	P	-	Structure	Structure
N-term	87	W	-	Structure	Structure
N-term	88	H	-	Structure	Structure
N-term	89	H	-	Structure	Structure
N-term	90	K	-	Structure	Structure
N-term	91	V	-	Structure	Structure
N-term	92	Q	-	Structure	Structure
N-term	93	H	-	Structure	Structure
N-term	94	R	-	Structure	Structure
N-term	95	F	-	Structure	Structure
N-term	96	V	-	Structure	Structure
N-term	97	F	-	Structure	Structure
N-term	98	K	-	Structure	Structure
N-term	99	R	-	Structure	Structure
N-term	100	C	-	Structure	Structure
N-term	101	G	-	Structure	Structure
N-term	102	P	-	Structure	Structure
N-term	103	D	-	Structure	Structure
N-term	104	G	-	Structure	Structure
N-term	105	Q	-	Structure	Structure
N-term	106	W	-	Structure	Structure
N-term	107	V	-	Structure	Structure
N-term	108	R	-	Structure	Structure
N-term	109	G	-	Structure	Structure
N-term	110	P	-	Structure	Structure
N-term	111	R	-	Structure	Structure
N-term	112	G	-	Structure	Structure
N-term	113	Q	-	Structure	Structure
N-term	114	P	-	Structure	Structure
N-term	115	W	-	Structure	Structure
N-term	116	R	-	Structure	AF2
N-term	117	D	-	Structure	Structure
N-term	118	A	-	Structure	Structure
N-term	119	S	-	Structure	Structure
N-term	120	Q	-	Structure	Structure
N-term	121	C	-	Structure	Structure
N-term	122	Q	-	Structure	Structure
N-term	123	M	-	Structure	Structure
N-term	124	D	-	Structure	Structure
N-term	125	G	-	Structure	Structure
N-term	126	E	-	Structure	AF2
N-term	127	E	-	Structure	Structure
N-term	128	I	-	Structure	Structure
N-term	129	E	-	Structure	Structure
N-term	130	V	-	Structure	Structure
TM1	131	Q	1.29x29	Structure	Structure
TM1	132	K	1.30x30	Structure	Structure
TM1	133	E	1.31x31	Structure	Structure
TM1	134	V	1.32x32	Structure	Structure
TM1	135	A	1.33x33	Structure	Structure
TM1	136	K	1.34x34	Structure	Structure
TM1	137	M	1.35x35	Structure	Structure
TM1	138	Y	1.36x36	Structure	Structure
TM1	139	S	1.37x37	Structure	Structure
TM1	140	S	1.38x38	Structure	Structure
TM1	141	F	1.39x39	Structure	Structure
TM1	142	Q	1.40x40	Structure	Structure
TM1	143	V	1.41x41	Structure	Structure
TM1	144	M	1.42x42	Structure	Structure
TM1	145	Y	1.43x43	Structure	Structure
TM1	146	T	1.44x44	Structure	Structure
TM1	147	V	1.45x45	Structure	Structure
TM1	148	G	1.46x46	Structure	Structure
TM1	149	Y	1.47x47	Structure	Structure
TM1	150	S	1.48x48	Structure	Structure
TM1	151	L	1.49x49	Structure	Structure
TM1	152	S	1.50x50	Structure	Structure
TM1	153	L	1.51x51	Structure	Structure
TM1	154	G	1.52x52	Structure	Structure
TM1	155	A	1.53x53	Structure	Structure
TM1	156	L	1.54x54	Structure	Structure
TM1	157	L	1.55x55	Structure	Structure
TM1	158	L	1.56x56	Structure	Structure
TM1	159	A	1.57x57	Structure	Structure
TM1	160	L	1.58x58	Structure	Structure
TM1	161	A	1.59x59	Structure	Structure
TM1	162	I	1.60x60	Structure	Structure
TM1	163	L	1.61x61	Structure	Structure
TM1	164	G	1.62x62	Structure	Structure
TM1	165	G	1.63x63	Structure	Structure
TM1	166	L	1.64x64	Structure	Structure
ICL1	167	S	12.48x48	Structure	Structure
ICL1	168	K	12.49x49	Structure	Structure
ICL1	169	L	12.50x50	Structure	Structure
ICL1	170	H	12.51x51	Structure	Structure
TM2	171	C	2.44x44	Structure	Structure
TM2	172	T	2.45x45	Structure	Structure
TM2	173	R	2.46x46	Structure	Structure
TM2	174	N	2.47x47	Structure	Structure
TM2	175	A	2.48x48	Structure	Structure
TM2	176	I	2.49x49	Structure	Structure
TM2	177	H	2.50x50	Structure	Structure
TM2	178	A	2.51x51	Structure	Structure
TM2	179	N	2.52x52	Structure	Structure
TM2	180	L	2.53x53	Structure	Structure
TM2	181	F	2.54x54	Structure	Structure
TM2	182	A	2.55x55	Structure	Structure
TM2	183	S	2.56x56	Structure	Structure
TM2	184	F	2.57x57	Structure	Structure
TM2	185	V	2.58x58	Structure	Structure
TM2	186	L	2.59x59	Structure	Structure
TM2	187	K	2.60x60	Structure	Structure
TM2	188	A	2.61x61	Structure	Structure
TM2	189	S	2.62x62	Structure	Structure
TM2	190	S	2.63x63	Structure	Structure
TM2	191	V	2.64x64	Structure	Structure
TM2	192	L	2.65x65	Structure	Structure
TM2	193	V	2.66x66	Structure	Structure
TM2	194	I	2.67x67	Structure	Structure
TM2	195	D	2.68x68	Structure	Structure
TM2	196	G	2.69x69	Structure	Structure
TM2	197	L	2.70x70	Structure	Structure
TM2	198	L	2.71x71	Structure	Structure
TM2	199	R	2.72x72	Structure	Structure
TM2	200	T	2.73x73	Structure	AF2
TM2	201	R	2.74x74	Structure	Structure
TM2	202	Y	2.75x75	Structure	Structure
TM2	203	S	2.76x76	Structure	Structure
ECL1	204	Q	-	Structure	Structure
ECL1	205	K	-	Structure	AF2
ECL1	206	I	-	Structure	Structure
ECL1	207	G	-	Structure	Structure
ECL1	208	D	-	Structure	AF2
ECL1	209	D	-	Structure	Structure
ECL1	210	L	-	Structure	Structure
ECL1	211	S	-	Structure	Structure
ECL1	212	V	-	Structure	Structure
ECL1	213	S	-	Structure	Structure
ECL1	214	T	-	Structure	Structure
ECL1	215	W	-	Structure	Structure
ECL1	216	L	-	Structure	Structure
ECL1	217	S	-	Structure	Structure
ECL1	218	D	-	Structure	AF2
ECL1	219	G	-	Structure	Structure
TM3	220	A	3.25x25	Structure	Structure
TM3	221	V	3.26x26	Structure	Structure
TM3	222	A	3.27x27	Structure	Structure
TM3	223	G	3.28x28	Structure	Structure
TM3	224	C	3.29x29	Structure	Structure
TM3	225	R	3.30x30	Structure	Structure
TM3	226	V	3.31x31	Structure	Structure
TM3	227	A	3.32x32	Structure	Structure
TM3	228	A	3.33x33	Structure	Structure
TM3	229	V	3.34x34	Structure	Structure
TM3	230	F	3.35x35	Structure	Structure
TM3	231	M	3.36x36	Structure	Structure
TM3	232	Q	3.37x37	Structure	Structure
TM3	233	Y	3.38x38	Structure	Structure
TM3	234	G	3.39x39	Structure	Structure
TM3	235	I	3.40x40	Structure	Structure
TM3	236	V	3.41x41	Structure	Structure
TM3	237	A	3.42x42	Structure	Structure
TM3	238	N	3.43x43	Structure	Structure
TM3	239	Y	3.44x44	Structure	Structure
TM3	240	C	3.45x45	Structure	Structure
TM3	241	W	3.46x46	Structure	Structure
TM3	242	L	3.47x47	Structure	Structure
TM3	243	L	3.48x48	Structure	Structure
TM3	244	V	3.49x49	Structure	Structure
TM3	245	E	3.50x50	Structure	Structure
TM3	246	G	3.51x51	Structure	Structure
TM3	247	L	3.52x52	Structure	Structure
TM3	248	Y	3.53x53	Structure	Structure
TM3	249	L	3.54x54	Structure	Structure
TM3	250	H	3.55x55	Structure	Structure
TM3	251	N	3.56x56	Structure	Structure
TM3	252	L	3.57x57	Structure	Structure
TM3	253	L	3.58x58	Structure	Structure
TM3	254	G	3.59x59	Structure	Structure
TM3	255	L	3.60x60	Structure	Structure
ICL2	256	A	-	Structure	Structure
ICL2	257	T	-	Structure	Structure
ICL2	258	L	-	Structure	Structure
ICL2	259	P	-	Structure	Structure
ICL2	260	E	-	Structure	Structure
ICL2	261	R	-	Structure	Structure
TM4	262	S	4.40x41	Structure	Structure
TM4	263	F	4.41x42	Structure	Structure
TM4	264	F	4.42x43	Structure	Structure
TM4	265	S	4.43x44	Structure	Structure
TM4	266	L	4.44x45	Structure	Structure
TM4	267	Y	4.45x46	Structure	Structure
TM4	268	L	4.46x47	Structure	Structure
TM4	269	G	4.47x48	Structure	Structure
TM4	270	I	4.48x49	Structure	Structure
TM4	271	G	4.49x491	Structure	Structure
TM4	272	W	4.50x50	Structure	Structure
TM4	273	G	4.51x51	Structure	Structure
TM4	274	A	4.52x52	Structure	Structure
TM4	275	P	4.53x53	Structure	Structure
TM4	276	M	4.54x54	Structure	Structure
TM4	277	L	4.55x55	Structure	Structure
TM4	278	F	4.56x56	Structure	Structure
TM4	279	V	4.57x57	Structure	Structure
TM4	280	V	4.58x58	Structure	Structure
TM4	281	P	4.59x59	Structure	Structure
TM4	282	W	4.60x60	Structure	Structure
TM4	283	A	4.61x61	Structure	Structure
TM4	284	V	4.62x62	Structure	Structure
TM4	285	V	4.63x63	Structure	Structure
TM4	286	K	4.64x64	Structure	Structure
TM4	287	C	4.65x65	Structure	Structure
TM4	288	L	4.66x66	Structure	Structure
TM4	289	F	4.67x67	Structure	Structure
TM4	290	E	4.68x68	Structure	Structure
ECL2	291	N	-	Structure	Structure
ECL2	292	V	-	Structure	Structure
ECL2	293	Q	-	Structure	Structure
ECL2	294	C	45.50x50	Structure	Structure
ECL2	295	W	45.51x51	Structure	Structure
ECL2	296	T	45.52x52	Structure	Structure
ECL2	297	S	-	Structure	Structure
ECL2	298	N	-	Structure	Structure
ECL2	299	D	-	Structure	Structure
ECL2	300	N	-	Structure	Structure
ECL2	301	M	-	Structure	AF2
ECL2	302	G	-	Structure	Structure
ECL2	303	F	-	Structure	AF2
TM5	304	W	5.36x37	Structure	Structure
TM5	305	W	5.37x38	Structure	Structure
TM5	306	I	5.38x381	Structure	Structure
TM5	307	L	5.39x39	Structure	Structure
TM5	308	R	5.40x40	Structure	Structure
TM5	309	F	5.41x41	Structure	Structure
TM5	310	P	5.42x42	Structure	Structure
TM5	311	V	5.43x43	Structure	Structure
TM5	312	F	5.44x44	Structure	Structure
TM5	313	L	5.45x45	Structure	Structure
TM5	314	A	5.46x46	Structure	Structure
TM5	315	I	5.47x47	Structure	Structure
TM5	316	L	5.48x48	Structure	Structure
TM5	317	I	5.49x49	Structure	Structure
TM5	318	N	5.50x50	Structure	Structure
TM5	319	F	5.51x51	Structure	Structure
TM5	320	F	5.52x52	Structure	Structure
TM5	321	I	5.53x53	Structure	Structure
TM5	322	F	5.54x54	Structure	Structure
TM5	323	V	5.55x55	Structure	Structure
TM5	324	R	5.56x56	Structure	Structure
TM5	325	I	5.57x57	Structure	Structure
TM5	326	V	5.58x58	Structure	Structure
TM5	327	Q	5.59x59	Structure	Structure
TM5	328	L	5.60x60	Structure	Structure
TM5	329	L	5.61x61	Structure	Structure
TM5	330	V	5.62x62	Structure	Structure
TM5	331	A	5.63x63	Structure	Structure
TM5	332	K	5.64x64	Structure	Structure
TM5	333	L	5.65x65	Structure	Structure
TM5	334	R	5.66x66	Structure	Structure
TM5	335	A	5.67x67	Structure	Structure
ICL3	336	R	-	Structure	Structure
ICL3	337	Q	-	Structure	AF2
ICL3	338	M	-	Structure	AF2
ICL3	339	H	-	Structure	Structure
ICL3	340	H	-	Structure	AF2
ICL3	341	T	-	Structure	AF2
TM6	342	D	6.33x33	Structure	AF2
TM6	343	Y	6.34x34	Structure	Structure
TM6	344	K	6.35x35	Structure	Structure
TM6	345	F	6.36x36	Structure	Structure
TM6	346	R	6.37x37	Structure	Structure
TM6	347	L	6.38x38	Structure	Structure
TM6	348	A	6.39x39	Structure	Structure
TM6	349	K	6.40x40	Structure	Structure
TM6	350	S	6.41x41	Structure	Structure
TM6	351	T	6.42x42	Structure	Structure
TM6	352	L	6.43x43	Structure	Structure
TM6	353	T	6.44x44	Structure	Structure
TM6	354	L	6.45x45	Structure	Structure
TM6	355	I	6.46x46	Structure	Structure
TM6	356	P	6.47x47	Structure	Structure
TM6	357	L	6.48x48	Structure	Structure
TM6	358	L	6.49x49	Structure	Structure
TM6	359	G	6.50x50	Structure	Structure
TM6	360	V	6.51x51	Structure	Structure
TM6	361	H	6.52x52	Structure	Structure
TM6	362	E	6.53x53	Structure	AF2
TM6	363	V	6.54x54	Structure	Structure
TM6	364	V	6.55x55	Structure	Structure
TM6	365	F	6.56x56	Structure	Structure
TM6	366	A	6.57x57	Structure	AF2
TM6	367	F	6.58x58	Structure	AF2
TM6	368	V	6.59x59	Structure	Structure
TM6	369	T	6.60x60	Structure	Structure
TM6	370	D	6.61x61	Structure	Structure
ECL3	371	E	-	Structure	Structure
ECL3	372	H	-	Structure	Structure
ECL3	373	A	-	Structure	Structure
ECL3	374	Q	-	Structure	Structure
TM7	375	G	7.32x31	Structure	Structure
TM7	376	T	7.33x32	Structure	Structure
TM7	377	L	7.34x33	Structure	Structure
TM7	378	R	7.35x34	Structure	Structure
TM7	379	S	7.36x35	Structure	Structure
TM7	380	A	7.37x36	Structure	Structure
TM7	381	K	7.38x37	Structure	Structure
TM7	382	L	7.39x38	Structure	Structure
TM7	383	F	7.40x39	Structure	Structure
TM7	384	F	7.41x40	Structure	Structure
TM7	385	D	7.42x41	Structure	Structure
TM7	386	L	7.43x42	Structure	Structure
TM7	387	F	7.44x43	Structure	Structure
TM7	388	L	7.45x44	Structure	Structure
TM7	389	S	7.46x45	Structure	Structure
TM7	390	S	7.47x46	Structure	Structure
TM7	391	F	7.48x47	Structure	Structure
TM7	392	Q	7.49x49	Structure	Structure
TM7	393	G	7.50x50	Structure	Structure
TM7	394	L	7.51x51	Structure	Structure
TM7	395	L	7.52x52	Structure	Structure
TM7	396	V	7.53x53	Structure	Structure
TM7	397	A	7.54x54	Structure	Structure
TM7	398	V	7.55x55	Structure	Structure
TM7	399	L	7.56x56	Structure	Structure
TM7	400	Y	7.57x57	Structure	Structure
TM7	401	C	7.58x58	Structure	Structure
TM7	402	F	7.59x59	Structure	Structure
TM7	403	L	7.60x60	Structure	Structure
H8	404	N	8.47x47	Structure	Structure
H8	405	K	8.48x48	Structure	Structure
H8	406	E	8.49x49	Structure	Structure
H8	407	V	8.50x50	Structure	Structure
H8	408	Q	8.51x51	Structure	Structure
H8	409	S	8.52x52	Structure	Structure
H8	410	E	8.53x53	Structure	Structure
H8	411	L	8.54x54	Structure	Structure
H8	412	R	8.55x55	Structure	Structure
H8	413	R	8.56x56	Structure	Structure
H8	414	R	8.57x57	Structure	Structure
H8	415	W	8.58x58	Structure	Structure
H8	416	H	8.59x59	Structure	Structure
H8	417	R	8.60x60	Structure	Structure
H8	418	W	8.61x61	Structure	Structure
H8	419	R	8.62x62	Structure	Structure
H8	420	L	8.63x63	Structure	Structure
H8	421	G	8.64x64	Structure	Structure
H8	422	K	8.65x65	AF2	AF2
H8	423	V	8.66x66	AF2	AF2
H8	424	L	8.67x67	AF2	AF2
H8	425	W	8.68x68	AF2	AF2
H8	426	E	8.69x69	AF2	AF2
H8	427	E	8.70x70	AF2	AF2
H8	428	R	8.71x71	AF2	AF2
H8	429	N	8.72x72	AF2	AF2
C-term	430	T	-	AF2	AF2
C-term	431	S	-	AF2	AF2
C-term	432	N	-	AF2	AF2
C-term	433	H	-	AF2	AF2
C-term	434	R	-	AF2	AF2
C-term	435	A	-	AF2	AF2
C-term	436	S	-	AF2	AF2
C-term	437	S	-	AF2	AF2
C-term	438	S	-	AF2	AF2
C-term	439	P	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	ICL2	R	261	-	G.S1	K	35	G.S1.03
Hydrophobic	ICL2	T	257	-	G.s1h1	A	41	G.s1h1.02
Hydrophobic	ICL2	A	256	-	G.h2s4	G	217	G.h2s4.03
Hydrophobic	ICL3	H	339	-	G.H5	D	350	G.H5.22
Hydrophobic	ICL2	E	260	-	G.S1	K	35	G.S1.03
Hydrophobic	ICL2	T	257	-	G.S1	L	39	G.S1.07
Hydrophobic	ICL2	E	260	-	G.S1	L	39	G.S1.07
Hydrophobic	ICL2	T	257	-	G.h2s4	G	217	G.h2s4.03
Hydrophobic	ICL2	L	258	-	G.S1	L	38	G.S1.06
Hydrophobic	ICL2	A	256	-	G.s1h1	A	41	G.s1h1.02
Polar	ICL3	H	339	-	G.H5	D	350	G.H5.22
Polar	ICL2	L	258	-	G.S1	L	38	G.S1.06
Polar	ICL2	A	256	-	G.s1h1	A	41	G.s1h1.02
Van-der-waals	ICL2	R	261	-	G.S1	K	35	G.S1.03
Van-der-waals	ICL2	T	257	-	G.s1h1	A	41	G.s1h1.02
Van-der-waals	ICL2	A	256	-	G.h2s4	G	217	G.h2s4.03
Van-der-waals	ICL3	H	339	-	G.H5	D	350	G.H5.22
Van-der-waals	ICL2	E	260	-	G.S1	L	39	G.S1.07
Van-der-waals	ICL2	T	257	-	G.h2s4	G	217	G.h2s4.03
Van-der-waals	ICL2	L	258	-	G.S1	L	38	G.S1.06
Van-der-waals	ICL2	A	256	-	G.s1h1	A	41	G.s1h1.02

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Main reference

Refined structure (6LML) of Gi1 - glucagon receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (6LML) of G_i1 - glucagon receptor

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