CRF2 receptor - Go

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

P

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Nov. 9, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Urocortin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

urocortin 1, urocortin 2, corticotrophin-releasing hormone, urocortin 3



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 L 290 5x61 G.H5 L 353 G.H5.25
Ionic TM5 K 293 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 293 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 213 3x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 290 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 213 3x58 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 289 5x60 G.H5 I 344 G.H5.16
Polar TM3 A 212 3x57 G.H5 N 347 G.H5.19
Polar TM5 S 297 5x68 G.H5 Y 354 G.H5.26
Hydrophobic TM5 S 297 5x68 G.H5 Y 354 G.H5.26
Van-der-waals TM5 S 297 5x68 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 212 3x57 G.H5 C 351 G.H5.23
Polar TM6 K 307 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 307 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 307 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 315 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM4 R 221 4x40 G.HN R 24 G.HN.48
Hydrophobic TM3 L 209 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 293 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 293 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 311 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 293 5x64 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 213 3x58 G.H5 L 348 G.H5.20
Polar TM4 T 219 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 219 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 219 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 K 307 6x37 G.H5 Y 354 G.H5.26
Hydrophobic TM5 I 286 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 293 5x64 G.H5 A 345 G.H5.17
Hydrophobic TM5 K 293 5x64 G.H5 Y 354 G.H5.26