V2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7BB7

RESOLUTION

4.4 Å

REFERENCE

10.1126/SCIADV.ABG5628

PUBLICATION DATE

June 2, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

vasopressin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

oxytocin, vasopressin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 I 74 - G.H5 H 387 G.H5.19
Hydrophobic TM7 F 328 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 F 328 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM3 M 133 3x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL1 H 70 - G.HN Q 31 G.HN.48
Van-der-waals ICL1 H 70 - G.HN Q 31 G.HN.48
Polar H8 S 329 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 S 329 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 S 329 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM3 A 140 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL1 V 76 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 V 76 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 228 5x61 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 228 5x61 G.H5 Q 384 G.H5.16
Polar ICL1 R 67 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 T 273 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 T 269 6x33 G.H5 R 385 G.H5.17
Hydrophobic TM6 M 272 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 H 387 G.H5.19
Polar TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 272 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 272 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL1 I 78 - G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 228 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM7 S 327 7x55 G.H5 L 393 G.H5.25
Van-der-waals TM7 S 327 7x55 G.H5 L 393 G.H5.25
Polar TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Hydrophobic ICL1 H 70 - G.HN Q 35 G.HN.52
Van-der-waals ICL1 H 70 - G.HN Q 35 G.HN.52
Hydrophobic TM3 A 140 3x53 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 140 3x53 G.H5 R 380 G.H5.12
Hydrophobic TM7 F 328 7x56 G.H5 E 392 G.H5.24
Polar TM3 R 137 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 137 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 137 3x50 G.H5 L 394 G.H5.26
Polar ICL1 R 64 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 64 - G.H5 Q 390 G.H5.22
Hydrophobic TM3 I 141 3x54 G.H5 L 394 G.H5.26
Van-der-waals TM3 I 141 3x54 G.H5 L 394 G.H5.26
Hydrophobic TM3 C 142 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 142 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM4 R 158 4x44 G.HN Q 31 G.HN.48
Hydrophobic TM3 M 133 3x46 G.H5 L 394 G.H5.26
Van-der-waals TM3 M 133 3x46 G.H5 L 394 G.H5.26
Van-der-waals ICL1 G 69 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 I 276 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 276 6x40 G.H5 L 393 G.H5.25
Hydrophobic H8 S 329 8x47 G.H5 Y 391 G.H5.23
Hydrophobic TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 140 3x53 G.H5 I 383 G.H5.15
Hydrophobic ICL1 I 74 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 I 74 - G.H5 Q 390 G.H5.22
Hydrophobic TM7 F 328 7x56 G.H5 Y 391 G.H5.23
Van-der-waals TM7 F 328 7x56 G.H5 Y 391 G.H5.23
Hydrophobic TM5 E 231 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 E 231 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL1 P 73 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 141 3x54 G.H5 L 388 G.H5.20
Ionic TM3 D 136 3x49 G.H5 H 387 G.H5.19
Polar TM3 D 136 3x49 G.H5 H 387 G.H5.19
Ionic ICL3 H 233 - G.hgh4 E 322 G.hgh4.12
Polar ICL3 H 233 - G.hgh4 E 322 G.hgh4.12