FFA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8J23

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 17, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

butyric acid, trans-2-methylcrotonic acid, propanoic acid, acetic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 115 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 V 115 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 Y 117 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 117 - G.H5 N 347 G.H5.19
Polar TM6 R 215 6x30 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 215 6x30 G.h4s6 T 316 G.h4s6.10
Polar TM6 R 218 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 218 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 218 6x33 G.H5 F 354 G.H5.26
Polar ICL1 Q 40 - G.HN E 28 G.HN.52
Hydrophobic ICL1 Q 40 - G.HN E 28 G.HN.52
Van-der-waals ICL1 Q 40 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 118 - G.S1 V 34 G.S1.02
Hydrophobic TM2 V 44 2x39 G.H5 D 350 G.H5.22
Polar ICL2 R 121 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 121 - G.hns1 R 32 G.hns1.03
Ionic TM4 R 122 4x38 G.HN E 28 G.HN.52
Polar TM2 H 45 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM2 H 45 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 H 45 2x40 G.H5 D 350 G.H5.22
Polar TM6 R 218 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 218 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 218 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL2 L 119 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 F 201 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 F 201 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 219 6x34 G.H5 F 354 G.H5.26
Polar TM3 G 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 110 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 115 - G.S3 L 194 G.S3.01
Hydrophobic TM2 A 42 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 215 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 215 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 222 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 222 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 115 - G.H5 I 343 G.H5.15
Ionic ICL3 H 210 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 210 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 210 - G.h4s6 E 318 G.h4s6.12
Polar TM6 R 215 6x30 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 R 107 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 205 - G.H5 L 348 G.H5.20
Hydrophobic TM6 R 215 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 215 6x30 G.H5 F 354 G.H5.26
Polar ICL2 R 121 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 121 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 114 - G.H5 I 343 G.H5.15
Hydrophobic TM3 V 111 3x54 G.H5 I 344 G.H5.16
Polar ICL2 P 114 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 114 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 118 - G.H5 I 343 G.H5.15
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM4 R 122 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Polar ICL3 H 210 - G.H5 K 345 G.H5.17
Hydrophobic TM3 V 111 3x54 G.H5 L 348 G.H5.20
Aromatic ICL3 H 210 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 H 210 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 H 210 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 V 115 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 115 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 114 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 114 - G.H5 I 344 G.H5.16
Hydrophobic ICL1 Q 40 - G.HN G 27 G.HN.51
Van-der-waals ICL1 Q 40 - G.HN G 27 G.HN.51
Hydrophobic TM6 A 219 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 219 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 119 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 - G.hns1 R 32 G.hns1.03