Refined structure (8X79) of Gs - IP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-27

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 231 from structure (58.6%), 163 from model (41.4%)
Residue sidechains - 221 from structure (56.1%), 173 from model (43.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure Structure
G.H1 64 H G.H1.12 Structure Structure
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure AF2
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure AF2
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 AF2 AF2
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 301 from structure (93.2%), 22 from model (6.8%)
Residue sidechains - 300 from structure (92.9%), 23 from model (7.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 D - AF2 AF2
N-term 4 S - Structure Structure
N-term 5 C - Structure Structure
N-term 6 R - Structure Structure
N-term 7 N - Structure Structure
N-term 8 L - Structure Structure
N-term 9 T - Structure Structure
N-term 10 Y - Structure Structure
N-term 11 V - Structure Structure
N-term 12 R - Structure Structure
N-term 13 G - Structure Structure
N-term 14 S - Structure Structure
N-term 15 V - Structure Structure
N-term 16 G - Structure Structure
TM1 17 P 1.36x36 Structure Structure
TM1 18 A 1.37x37 Structure Structure
TM1 19 T 1.38x38 Structure Structure
TM1 20 S 1.39x39 Structure Structure
TM1 21 T 1.40x40 Structure Structure
TM1 22 L 1.41x41 Structure Structure
TM1 23 M 1.42x42 Structure Structure
TM1 24 F 1.43x43 Structure Structure
TM1 25 V 1.44x44 Structure Structure
TM1 26 A 1.45x45 Structure Structure
TM1 27 G 1.46x46 Structure Structure
TM1 28 V 1.47x47 Structure Structure
TM1 29 V 1.48x48 Structure Structure
TM1 30 G 1.49x49 Structure Structure
TM1 31 N 1.50x50 Structure Structure
TM1 32 G 1.51x51 Structure Structure
TM1 33 L 1.52x52 Structure Structure
TM1 34 A 1.53x53 Structure Structure
TM1 35 L 1.54x54 Structure Structure
TM1 36 G 1.55x55 Structure Structure
TM1 37 I 1.56x56 Structure Structure
TM1 38 L 1.57x57 Structure Structure
TM1 39 S 1.58x58 Structure Structure
TM1 40 A 1.59x59 Structure Structure
TM1 41 R 1.60x60 Structure Structure
ICL1 42 R - Structure Structure
ICL1 43 P - Structure Structure
ICL1 44 A - Structure Structure
ICL1 45 R - Structure Structure
ICL1 46 P - Structure Structure
TM2 47 S 2.37x37 Structure Structure
TM2 48 A 2.38x38 Structure Structure
TM2 49 F 2.39x39 Structure Structure
TM2 50 A 2.40x40 Structure Structure
TM2 51 V 2.41x41 Structure Structure
TM2 52 L 2.42x42 Structure Structure
TM2 53 V 2.43x43 Structure Structure
TM2 54 T 2.44x44 Structure Structure
TM2 55 G 2.45x45 Structure Structure
TM2 56 L 2.46x46 Structure Structure
TM2 57 A 2.47x47 Structure Structure
TM2 58 A 2.48x48 Structure Structure
TM2 59 T 2.49x49 Structure Structure
TM2 60 D 2.50x50 Structure Structure
TM2 61 L 2.51x51 Structure Structure
TM2 62 L 2.52x52 Structure Structure
TM2 63 G 2.53x53 Structure Structure
TM2 64 T 2.54x54 Structure Structure
TM2 65 S 2.55x55 Structure Structure
TM2 66 F 2.56x56 Structure Structure
TM2 67 L 2.57x57 Structure Structure
TM2 68 S 2.58x58 Structure Structure
TM2 69 P 2.59x59 Structure Structure
TM2 70 A 2.60x60 Structure Structure
TM2 71 V 2.61x61 Structure Structure
TM2 72 F 2.62x62 Structure Structure
TM2 73 V 2.63x63 Structure Structure
TM2 74 A 2.64x64 Structure Structure
TM2 75 Y 2.65x65 Structure Structure
TM2 76 A 2.66x66 Structure Structure
TM2 77 R 2.67x67 Structure Structure
TM2 78 N 2.68x68 Structure Structure
ECL1 79 S - Structure Structure
ECL1 80 S - Structure Structure
ECL1 81 L - Structure Structure
ECL1 82 L - Structure Structure
ECL1 83 G - Structure Structure
ECL1 84 L - Structure Structure
ECL1 85 A - Structure Structure
ECL1 86 R - Structure Structure
ECL1 87 G - Structure Structure
ECL1 88 G - Structure Structure
TM3 89 P 3.22x22 Structure Structure
TM3 90 A 3.23x23 Structure Structure
TM3 91 L 3.24x24 Structure Structure
TM3 92 C 3.25x25 Structure Structure
TM3 93 D 3.26x26 Structure Structure
TM3 94 A 3.27x27 Structure Structure
TM3 95 F 3.28x28 Structure Structure
TM3 96 A 3.29x29 Structure Structure
TM3 97 F 3.30x30 Structure Structure
TM3 98 A 3.31x31 Structure Structure
TM3 99 M 3.32x32 Structure Structure
TM3 100 T 3.33x33 Structure Structure
TM3 101 F 3.34x34 Structure Structure
TM3 102 F 3.35x35 Structure Structure
TM3 103 G 3.36x36 Structure Structure
TM3 104 L 3.37x37 Structure Structure
TM3 105 A 3.38x38 Structure Structure
TM3 106 S 3.39x39 Structure Structure
TM3 107 M 3.40x40 Structure Structure
TM3 108 L 3.41x41 Structure Structure
TM3 109 I 3.42x42 Structure Structure
TM3 110 L 3.43x43 Structure Structure
TM3 111 F 3.44x44 Structure Structure
TM3 112 A 3.45x45 Structure Structure
TM3 113 M 3.46x46 Structure Structure
TM3 114 A 3.47x47 Structure Structure
TM3 115 V 3.48x48 Structure Structure
TM3 116 E 3.49x49 Structure Structure
TM3 117 R 3.50x50 Structure Structure
TM3 118 C 3.51x51 Structure Structure
TM3 119 L 3.52x52 Structure Structure
TM3 120 A 3.53x53 Structure Structure
TM3 121 L 3.54x54 Structure Structure
TM3 122 S 3.55x55 Structure Structure
TM3 123 H 3.56x56 Structure Structure
ICL2 124 P 34.50x50 Structure Structure
ICL2 125 Y 34.51x51 Structure Structure
ICL2 126 L 34.52x52 Structure Structure
ICL2 127 Y 34.53x53 Structure Structure
ICL2 128 A 34.54x54 Structure Structure
ICL2 129 Q 34.55x55 Structure Structure
ICL2 130 L 34.56x56 Structure Structure
ICL2 131 D 34.57x57 Structure Structure
TM4 132 G 4.38x38 Structure Structure
TM4 133 P 4.39x39 Structure Structure
TM4 134 R 4.40x40 Structure Structure
TM4 135 C 4.41x41 Structure Structure
TM4 136 A 4.42x42 Structure Structure
TM4 137 R 4.43x43 Structure Structure
TM4 138 L 4.44x44 Structure Structure
TM4 139 A 4.45x45 Structure Structure
TM4 140 L 4.46x46 Structure Structure
TM4 141 P 4.47x47 Structure Structure
TM4 142 A 4.48x48 Structure Structure
TM4 143 I 4.49x49 Structure Structure
TM4 144 Y 4.50x50 Structure Structure
TM4 145 A 4.51x51 Structure Structure
TM4 146 F 4.52x52 Structure Structure
TM4 147 C 4.53x53 Structure Structure
TM4 148 V 4.54x54 Structure Structure
TM4 149 L 4.55x55 Structure Structure
TM4 150 F 4.56x56 Structure Structure
TM4 151 C 4.57x57 Structure Structure
TM4 152 A 4.58x58 Structure Structure
TM4 153 L 4.59x59 Structure Structure
TM4 154 P 4.60x60 Structure Structure
TM4 155 L 4.61x61 Structure Structure
TM4 156 L 4.62x62 Structure Structure
TM4 157 G 4.63x63 Structure Structure
ECL2 158 L - Structure Structure
ECL2 159 G - Structure Structure
ECL2 160 Q - Structure Structure
ECL2 161 H - Structure Structure
ECL2 162 Q - Structure Structure
ECL2 163 Q - Structure Structure
ECL2 164 Y - Structure Structure
ECL2 165 C - Structure Structure
ECL2 166 P - Structure Structure
ECL2 167 G - Structure Structure
ECL2 168 S - Structure Structure
ECL2 169 W - Structure Structure
ECL2 170 C 45.50x50 Structure Structure
ECL2 171 F 45.51x51 Structure AF2
ECL2 172 L 45.52x52 Structure Structure
ECL2 173 R - Structure Structure
ECL2 174 M - Structure Structure
ECL2 175 R - Structure Structure
ECL2 176 W - Structure Structure
ECL2 177 A - Structure Structure
TM5 178 Q 5.31x31 Structure Structure
TM5 179 P 5.32x32 Structure Structure
TM5 180 G 5.33x33 Structure Structure
TM5 181 G 5.34x34 Structure Structure
TM5 182 A 5.35x35 Structure Structure
TM5 183 A 5.36x36 Structure Structure
TM5 184 F 5.37x37 Structure Structure
TM5 185 S 5.38x38 Structure Structure
TM5 186 L 5.39x39 Structure Structure
TM5 187 A 5.40x40 Structure Structure
TM5 188 Y 5.41x41 Structure Structure
TM5 189 A 5.42x42 Structure Structure
TM5 190 G 5.43x43 Structure Structure
TM5 191 L 5.44x44 Structure Structure
TM5 192 V 5.45x45 Structure Structure
TM5 193 A 5.46x46 Structure Structure
TM5 194 L 5.47x47 Structure Structure
TM5 195 L 5.48x48 Structure Structure
TM5 196 V 5.49x49 Structure Structure
TM5 197 A 5.50x50 Structure Structure
TM5 198 A 5.51x51 Structure Structure
TM5 199 I 5.52x52 Structure Structure
TM5 200 F 5.53x53 Structure Structure
TM5 201 L 5.54x54 Structure Structure
TM5 202 C 5.55x55 Structure Structure
TM5 203 N 5.56x56 Structure Structure
TM5 204 G 5.57x57 Structure Structure
TM5 205 S 5.58x58 Structure Structure
TM5 206 V 5.59x59 Structure Structure
TM5 207 T 5.60x60 Structure Structure
TM5 208 L 5.61x61 Structure Structure
TM5 209 S 5.62x62 Structure Structure
TM5 210 L 5.63x63 Structure Structure
TM5 211 C 5.64x64 Structure Structure
TM5 212 R 5.65x65 Structure Structure
TM5 213 M 5.66x66 Structure Structure
TM5 214 Y 5.67x67 Structure Structure
TM5 215 R 5.68x68 Structure Structure
TM5 216 Q 5.69x69 Structure Structure
TM5 217 Q 5.70x70 Structure Structure
TM5 218 K 5.71x71 Structure Structure
TM5 219 R 5.72x72 Structure Structure
TM5 220 H 5.73x73 Structure Structure
TM5 221 Q 5.74x74 Structure Structure
ICL3 222 G - Structure Structure
ICL3 223 S - AF2 AF2
ICL3 224 L - AF2 AF2
ICL3 225 G - AF2 AF2
ICL3 226 P - AF2 AF2
ICL3 227 R - AF2 AF2
ICL3 228 P - AF2 AF2
ICL3 229 R - AF2 AF2
ICL3 230 T - AF2 AF2
ICL3 231 G - AF2 AF2
ICL3 232 E - Structure Structure
TM6 233 D 6.29x29 Structure Structure
TM6 234 E 6.30x30 Structure Structure
TM6 235 V 6.31x31 Structure Structure
TM6 236 D 6.32x32 Structure Structure
TM6 237 H 6.33x33 Structure Structure
TM6 238 L 6.34x34 Structure Structure
TM6 239 I 6.35x35 Structure Structure
TM6 240 L 6.36x36 Structure Structure
TM6 241 L 6.37x37 Structure Structure
TM6 242 A 6.38x38 Structure Structure
TM6 243 L 6.39x39 Structure Structure
TM6 244 M 6.40x40 Structure Structure
TM6 245 T 6.41x41 Structure Structure
TM6 246 V 6.42x42 Structure Structure
TM6 247 V 6.43x43 Structure Structure
TM6 248 M 6.44x44 Structure Structure
TM6 249 A 6.45x45 Structure Structure
TM6 250 V 6.46x46 Structure Structure
TM6 251 C 6.47x47 Structure Structure
TM6 252 S 6.48x48 Structure Structure
TM6 253 L 6.49x49 Structure Structure
TM6 254 P 6.50x50 Structure Structure
TM6 255 L 6.51x51 Structure Structure
TM6 256 T 6.52x52 Structure Structure
TM6 257 I 6.53x53 Structure Structure
TM6 258 R 6.54x54 Structure Structure
TM6 259 C 6.55x55 Structure Structure
TM6 260 F 6.56x56 Structure Structure
TM6 261 T 6.57x57 Structure Structure
TM6 262 Q 6.58x58 Structure Structure
TM6 263 A 6.59x59 Structure Structure
TM6 264 V 6.60x60 Structure Structure
TM6 265 A 6.61x61 Structure Structure
ECL3 266 P - Structure Structure
ECL3 267 D - Structure Structure
ECL3 268 S - Structure Structure
ECL3 269 S - Structure Structure
ECL3 270 S - Structure Structure
ECL3 271 E - Structure Structure
ECL3 272 M - Structure Structure
ECL3 273 G - Structure Structure
TM7 274 D 7.35x34 Structure Structure
TM7 275 L 7.36x35 Structure Structure
TM7 276 L 7.37x36 Structure Structure
TM7 277 A 7.38x37 Structure Structure
TM7 278 F 7.39x38 Structure Structure
TM7 279 R 7.40x39 Structure Structure
TM7 280 F 7.41x40 Structure Structure
TM7 281 Y 7.42x41 Structure Structure
TM7 282 A 7.43x42 Structure Structure
TM7 283 F 7.44x43 Structure Structure
TM7 284 N 7.45x45 Structure Structure
TM7 285 P 7.46x46 Structure Structure
TM7 286 I 7.47x47 Structure Structure
TM7 287 L 7.48x48 Structure Structure
TM7 288 D 7.49x49 Structure Structure
TM7 289 P 7.50x50 Structure Structure
TM7 290 W 7.51x51 Structure Structure
TM7 291 V 7.52x52 Structure Structure
TM7 292 F 7.53x53 Structure Structure
TM7 293 I 7.54x54 Structure Structure
TM7 294 L 7.55x55 Structure Structure
TM7 295 F 7.56x56 Structure Structure
H8 296 R 8.47x47 Structure Structure
H8 297 K 8.48x48 Structure Structure
H8 298 A 8.49x49 Structure Structure
H8 299 V 8.50x50 Structure Structure
H8 300 F 8.51x51 Structure Structure
H8 301 Q 8.52x52 Structure Structure
H8 302 R 8.53x53 Structure Structure
H8 303 L 8.54x54 Structure Structure
H8 304 K 8.55x55 Structure Structure
H8 305 L 8.56x56 Structure Structure
H8 306 W 8.57x57 Structure Structure
H8 307 V 8.58x58 Structure Structure
H8 308 C 8.59x59 Structure Structure
H8 309 C 8.60x60 Structure Structure
H8 310 L 8.61x61 Structure Structure
H8 311 C 8.62x62 Structure Structure
H8 312 L 8.63x63 Structure Structure
H8 313 G 8.64x64 Structure Structure
C-term 314 P - AF2 AF2
C-term 315 A - AF2 AF2
C-term 316 H - AF2 AF2
C-term 317 G - AF2 AF2
C-term 318 D - AF2 AF2
C-term 319 S - AF2 AF2
C-term 320 Q - AF2 AF2
C-term 321 T - AF2 AF2
C-term 322 P - AF2 AF2
C-term 323 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 A 128 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 A 128 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 125 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 125 34x51 G.H5 C 379 G.H5.11
Polar ICL2 Q 129 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Q 129 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 213 5x66 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 213 5x66 G.H5 Q 384 G.H5.16
Hydrophobic TM2 F 49 2x39 G.H5 L 393 G.H5.25
Polar TM5 Q 221 5x74 G.H4 R 342 G.H4.12
Polar TM6 H 237 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 237 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 H 237 6x33 G.H5 L 388 G.H5.20
Polar TM5 Q 217 5x70 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 Q 217 5x70 G.h4s6 Y 358 G.h4s6.20
Polar ICL3 R 227 - G.H4 L 346 G.H4.16
Polar ICL3 T 230 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 T 230 - G.h4s6 D 354 G.h4s6.10
Van-der-waals ICL3 T 230 - G.h4s6 D 354 G.h4s6.10
Ionic ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Polar ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 131 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 G 222 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 L 224 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 L 224 - G.H4 D 343 G.H4.13
Aromatic ICL2 Y 127 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 127 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 H 237 6x33 G.H5 Y 391 G.H5.23
Hydrophobic TM6 E 234 6x30 G.H5 L 388 G.H5.20
Aromatic TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 49 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 H 220 5x73 G.S6 H 362 G.S6.04
Hydrophobic TM3 A 120 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 120 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Aromatic ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 125 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL1 A 44 - G.H5 L 393 G.H5.25
Polar TM2 S 47 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 S 47 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 47 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 A 50 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 213 5x66 G.H5 D 381 G.H5.13
Hydrophobic ICL3 L 224 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 L 224 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 P 124 34x50 G.H5 I 383 G.H5.15
Polar ICL3 S 223 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 T 230 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 T 230 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 T 230 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 E 116 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 116 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 116 3x49 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Hydrophobic H8 A 298 8x49 G.H5 L 394 G.H5.26
Van-der-waals H8 A 298 8x49 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 121 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 121 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 A 120 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 H 387 G.H5.19
Polar ICL2 L 130 34x56 G.hns1 R 38 G.hns1.02
Hydrophobic TM1 L 38 1x57 G.H5 L 393 G.H5.25
Van-der-waals TM1 L 38 1x57 G.H5 L 393 G.H5.25
Hydrophobic ICL3 L 224 - G.H4 L 346 G.H4.16
Polar ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 125 34x51 G.H5 R 380 G.H5.12
Polar TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 Q 384 G.H5.16
Polar H8 R 296 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 296 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 R 296 8x47 G.H5 Y 391 G.H5.23
Polar ICL2 P 124 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 124 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 217 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 217 5x70 G.H5 R 385 G.H5.17
Hydrophobic ICL2 Q 129 34x55 G.hns1 A 39 G.hns1.03
Polar TM5 R 219 5x72 G.H4 R 342 G.H4.12
Hydrophobic TM1 R 41 1x60 G.H5 L 393 G.H5.25
Hydrophobic ICL3 T 230 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 G 222 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 P 124 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 124 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 124 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 124 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 121 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 125 34x51 G.H5 I 383 G.H5.15
Hydrophobic H8 V 299 8x50 G.H5 L 394 G.H5.26
Van-der-waals H8 V 299 8x50 G.H5 L 394 G.H5.26
Aromatic TM5 H 220 5x73 G.S6 Y 360 G.S6.02
Hydrophobic TM5 H 220 5x73 G.S6 Y 360 G.S6.02
Hydrophobic ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 210 5x63 G.H5 L 388 G.H5.20
Hydrophobic ICL3 R 227 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 R 227 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 Y 125 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 Y 125 34x51 G.S3 F 219 G.S3.03
Polar TM3 S 122 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 S 122 3x55 G.H5 R 380 G.H5.12
Ionic ICL2 D 131 34x57 G.HN K 34 G.HN.51
Polar ICL2 D 131 34x57 G.HN K 34 G.HN.51
Hydrophobic H8 V 299 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 V 299 8x50 G.H5 L 393 G.H5.25
Ionic TM6 E 234 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 234 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 234 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM6 H 237 6x33 G.H5 E 392 G.H5.24