M3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

Nov. 30, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL73538 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 174 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 L 174 - G.H5 I 235 G.H5.15
Hydrophobic TM5 I 254 5x61 G.H5 L 245 G.H5.25
Hydrophobic TM2 N 103 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM5 L 265 5x72 G.H5 Q 237 G.H5.17
Hydrophobic TM5 T 258 5x65 G.H5 L 245 G.H5.25
Van-der-waals TM5 T 258 5x65 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 174 - G.H5 K 232 G.H5.12
Hydrophobic TM5 T 258 5x65 G.H5 V 246 G.H5.26
Van-der-waals TM5 T 258 5x65 G.H5 V 246 G.H5.26
Hydrophobic TM5 R 261 5x68 G.H5 L 236 G.H5.16
Hydrophobic ICL2 P 173 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 P 173 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 173 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 L 174 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 174 - G.H5 F 228 G.H5.08
Polar ICL2 A 178 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 178 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 170 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 240 G.H5.20
Van-der-waals H8 R 552 8x51 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 173 - G.H5 L 236 G.H5.16
Hydrophobic TM5 L 265 5x72 G.h4s6 I 210 G.h4s6.20
Hydrophobic ICL2 T 175 - G.S3 V 79 G.S3.01
Polar TM3 S 169 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 N 239 G.H5.19
Polar ICL2 R 177 - G.H5 Y 243 G.H5.23
Hydrophobic ICL2 R 177 - G.H5 Y 243 G.H5.23
Van-der-waals ICL2 R 177 - G.H5 Y 243 G.H5.23
Hydrophobic TM5 L 265 5x72 G.S6 Y 212 G.S6.02
Van-der-waals TM5 L 265 5x72 G.S6 Y 212 G.S6.02
Hydrophobic TM6 A 489 6x33 G.H5 V 246 G.H5.26
Van-der-waals TM6 A 489 6x33 G.H5 V 246 G.H5.26
Hydrophobic TM6 K 488 6x32 G.H5 L 245 G.H5.25
Van-der-waals TM6 K 488 6x32 G.H5 L 245 G.H5.25
Hydrophobic TM5 T 258 5x65 G.H5 L 240 G.H5.20
Polar ICL4 C 547 - G.H5 N 244 G.H5.24
Hydrophobic ICL4 C 547 - G.H5 N 244 G.H5.24
Van-der-waals ICL4 C 547 - G.H5 N 244 G.H5.24
Polar TM6 T 492 6x36 G.H5 N 244 G.H5.24
Van-der-waals TM6 T 492 6x36 G.H5 N 244 G.H5.24
Hydrophobic ICL2 L 174 - G.S3 V 79 G.S3.01
Ionic ICL2 R 177 - G.H5 E 242 G.H5.22
Polar ICL2 R 177 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 R 177 - G.H5 E 242 G.H5.22
Van-der-waals ICL2 R 177 - G.H5 E 242 G.H5.22
Hydrophobic TM3 I 170 3x54 G.H5 L 236 G.H5.16
Polar TM3 D 165 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 174 - G.H5 C 231 G.H5.11
Polar TM5 R 261 5x68 G.H5 Q 237 G.H5.17
Hydrophobic TM5 R 261 5x68 G.H5 Q 237 G.H5.17
Van-der-waals TM5 R 261 5x68 G.H5 Q 237 G.H5.17
Aromatic TM3 R 166 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 Y 243 G.H5.23
Polar TM6 A 489 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 489 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 A 489 6x33 G.H5 L 245 G.H5.25
Ionic TM5 R 261 5x68 G.H5 D 233 G.H5.13
Hydrophobic TM5 R 261 5x68 G.H5 D 233 G.H5.13
Van-der-waals TM5 R 261 5x68 G.H5 D 233 G.H5.13
Polar ICL2 R 177 - G.H5 N 239 G.H5.19
Hydrophobic ICL2 R 177 - G.H5 N 239 G.H5.19
Hydrophobic TM6 L 493 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 493 6x37 G.H5 L 245 G.H5.25
Polar TM3 S 169 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 S 169 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 170 3x54 G.H5 Y 243 G.H5.23
Polar TM6 K 488 6x32 G.H5 N 244 G.H5.24
Hydrophobic TM6 K 488 6x32 G.H5 N 244 G.H5.24
Van-der-waals TM6 K 488 6x32 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 170 3x54 G.H5 N 239 G.H5.19
Hydrophobic ICL2 L 174 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 174 - G.S1 L 34 G.S1.02
Hydrophobic TM5 R 261 5x68 G.H5 V 246 G.H5.26
Van-der-waals TM5 R 261 5x68 G.H5 V 246 G.H5.26
Hydrophobic TM5 L 265 5x72 G.H5 D 233 G.H5.13
Van-der-waals TM5 L 265 5x72 G.H5 D 233 G.H5.13