β1-adrenoceptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Meleagris gallopavo

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.9 Å

REFERENCE

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

LEVISOPRENALINE - Agonist chembl_ligand chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Aromatic ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 147 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 147 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 Q 237 5x68 G.H5 R 345 G.H5.17
Van-der-waals TM5 Q 237 5x68 G.H5 R 345 G.H5.17
Hydrophobic TM6 L 292 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 292 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM5 Q 237 5x68 G.H5 Q 344 G.H5.16
Ionic ICL4 R 345 - G.H5 E 352 G.H5.24
Polar ICL4 R 345 - G.H5 E 352 G.H5.24
Hydrophobic ICL4 R 345 - G.H5 E 352 G.H5.24
Van-der-waals ICL4 R 345 - G.H5 E 352 G.H5.24
Polar TM5 Q 237 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 237 5x68 G.H5 D 341 G.H5.13
Polar H8 S 346 8x47 G.H5 E 352 G.H5.24
Hydrophobic H8 S 346 8x47 G.H5 E 352 G.H5.24
Van-der-waals H8 S 346 8x47 G.H5 E 352 G.H5.24
Polar TM6 T 291 6x36 G.H5 E 352 G.H5.24
Hydrophobic TM6 T 291 6x36 G.H5 E 352 G.H5.24
Van-der-waals TM6 T 291 6x36 G.H5 E 352 G.H5.24
Hydrophobic TM5 I 238 5x69 G.H5 L 354 G.H5.26
Van-der-waals TM5 I 238 5x69 G.H5 L 354 G.H5.26
Polar ICL2 S 151 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 151 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 Q 237 5x68 G.H5 L 348 G.H5.20
Polar TM6 A 288 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 288 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 288 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 139 3x50 G.H5 Y 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 351 G.H5.23
Hydrophobic TM5 V 230 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 230 5x61 G.H5 L 353 G.H5.25
Polar H8 S 346 8x47 G.H5 Q 350 G.H5.22
Hydrophobic TM6 K 287 6x32 G.H5 L 354 G.H5.26
Hydrophobic ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 I 241 5x72 G.H5 R 345 G.H5.17
Van-der-waals TM5 I 241 5x72 G.H5 R 345 G.H5.17
Hydrophobic ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 143 3x54 G.H5 Y 351 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 Y 351 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 H 347 G.H5.19
Hydrophobic ICL2 F 147 34x51 G.H5 V 339 G.H5.11
Polar TM5 E 233 5x64 G.H5 Q 344 G.H5.16
Van-der-waals TM5 E 233 5x64 G.H5 Q 344 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 H 347 G.H5.19
Hydrophobic ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Polar TM3 I 143 3x54 G.H5 Q 344 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 Q 344 G.H5.16
Hydrophobic TM5 I 241 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 T 76 2x39 G.H5 Y 351 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 351 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 291 6x36 G.H5 L 353 G.H5.25