Refined structure (7Y26) of Gq - SST2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 214 from structure (59.6%), 145 from model (40.4%)
Residue sidechains - 94 from structure (26.2%), 265 from model (73.8%)

REFINED GPCR RESIDUES

Residue backbones - 270 from structure (79.9%), 68 from model (20.1%)
Residue sidechains - 203 from structure (60.1%), 135 from model (39.9%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
Y23G.H5GproteinR34x57GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H5GPCR segments:ICL2

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
2x373x533x5434x5034x5134x5534x575x615x658x49G.H5.25G.H5.23G.H5.22G.H5.20G.H5.15G.H5.12G.H5.08G.s2s3.02Res. Pos.SST2 (7Y26_REFINED)- (7Y26_REFINED)----------TAVPIKRIVNTPIKRAVIVNEKIFSYLL

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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