BLT1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VKT

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-022-28820-9

PUBLICATION DATE

March 9, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

LTB4 - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

20-hydroxy-LTB4, 12R-HETE, LTB4



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Ionic ICL3 R 212 - G.H5 D 341 G.H5.13
Polar ICL3 R 212 - G.H5 D 341 G.H5.13
Hydrophobic TM5 L 208 5x65 G.H5 L 348 G.H5.20
Hydrophobic C-term G 291 - G.H5 F 354 G.H5.26
Van-der-waals C-term G 291 - G.H5 F 354 G.H5.26
Polar ICL3 R 217 - G.H5 F 354 G.H5.26
Aromatic ICL3 R 217 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 R 217 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 217 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 T 219 - G.H5 L 353 G.H5.25
Van-der-waals ICL3 T 219 - G.H5 L 353 G.H5.25
Hydrophobic TM3 V 119 3x54 G.H5 I 344 G.H5.16
Polar C-term G 290 - G.H5 L 353 G.H5.25
Hydrophobic C-term G 290 - G.H5 L 353 G.H5.25
Polar TM4 T 130 4x38 G.HN E 28 G.HN.52
Hydrophobic C-term G 290 - G.H5 F 354 G.H5.26
Hydrophobic TM3 V 119 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 119 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL3 F 213 - G.H5 K 345 G.H5.17
Polar TM2 T 53 2x39 G.H5 D 350 G.H5.22
Polar ICL3 R 218 - G.H5 F 354 G.H5.26
Aromatic ICL3 R 218 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 R 218 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 218 - G.H5 F 354 G.H5.26
Hydrophobic TM5 R 211 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 T 219 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 F 123 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 123 34x51 G.H5 I 343 G.H5.15
Polar TM3 A 118 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 127 34x55 G.hns1 R 32 G.hns1.03
Ionic TM5 R 211 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 212 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 212 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 A 118 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 118 3x53 G.H5 C 351 G.H5.23
Polar TM3 D 114 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 114 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 114 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 215 - G.H5 F 354 G.H5.26
Hydrophobic C-term G 291 - G.H5 G 352 G.H5.24
Van-der-waals C-term G 291 - G.H5 G 352 G.H5.24
Van-der-waals C-term G 291 - G.H5 L 353 G.H5.25
Polar TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 123 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 123 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 115 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 126 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 122 34x50 G.H5 I 343 G.H5.15