BB2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W3Z

RESOLUTION

3.0 Å

REFERENCE

10.1073/PNAS.2216230120

PUBLICATION DATE

Feb. 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

86 interactions (Click to see)

LIGANDS

Gastrin-releasing peptide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

GRP-(18-27), neuromedin B, gastrin releasing peptide(14-27) (human), neuromedin C, gastrin-releasing peptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 L 322 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 262 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 262 6x33 G.H5 V 359 G.H5.26
Ionic TM6 K 254 6x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL3 P 245 - G.H5 A 343 G.H5.10
Polar ICL3 P 245 - G.S6 S 326 G.S6.03
Polar TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 259 6x30 G.H5 Q 350 G.H5.17
Polar ICL2 Q 149 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 Q 149 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Q 149 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL3 P 245 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 V 246 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 V 246 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 P 145 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 145 - G.H5 I 348 G.H5.15
Hydrophobic TM6 H 251 6x22 G.H4 V 314 G.H4.16
Van-der-waals TM6 H 251 6x22 G.H4 V 314 G.H4.16
Polar H8 S 326 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 326 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 326 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 H 251 6x22 G.H4 K 311 G.H4.13
Ionic H8 K 327 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 K 327 8x48 G.h4s6 D 321 G.h4s6.12
Ionic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 259 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 259 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 259 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 L 262 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM7 L 325 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM6 H 251 6x22 G.H4 L 310 G.H4.12
Hydrophobic TM6 V 252 6x23 G.h4s6 I 323 G.h4s6.20
Polar TM6 Q 255 6x26 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM3 R 138 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL3 L 244 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 L 244 - G.H5 D 346 G.H5.13
Hydrophobic ICL2 P 145 - G.H5 K 345 G.H5.12
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 E 247 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 E 247 - G.S6 S 326 G.S6.03
Ionic ICL3 E 247 - G.S6 H 327 G.S6.04
Polar ICL3 E 247 - G.S6 H 327 G.S6.04
Hydrophobic ICL3 E 247 - G.S6 H 327 G.S6.04
Polar H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 326 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 237 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL3 P 245 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 P 245 - G.H5 F 339 G.H5.06
Polar TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 352 G.H5.19
Polar ICL3 E 247 - G.S6 F 328 G.S6.05
Hydrophobic ICL3 E 247 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 E 247 - G.S6 F 328 G.S6.05
Ionic ICL2 D 147 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL3 V 246 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 L 244 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 358 G.H5.25
Hydrophobic H8 F 329 8x50 G.H5 N 357 G.H5.24
Hydrophobic ICL3 P 245 - G.H5 D 346 G.H5.13
Polar TM6 K 254 6x25 G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL3 P 245 - G.H5 A 342 G.H5.09
Polar TM6 Q 255 6x26 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 Q 255 6x26 G.h4s6 D 321 G.h4s6.12
Polar ICL2 S 151 - G.HN E 34 G.HN.52
Hydrophobic ICL2 S 151 - G.HN E 34 G.HN.52
Van-der-waals ICL2 S 151 - G.HN E 34 G.HN.52
Hydrophobic TM7 L 322 7x53 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 262 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 262 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL3 E 247 - G.H4 L 310 G.H4.12
Van-der-waals ICL3 E 247 - G.H4 L 310 G.H4.12
Van-der-waals ICL2 M 146 - G.s2s3 S 198 G.s2s3.02
Polar TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 237 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM6 Q 255 6x26 G.h4s6 I 323 G.h4s6.20