VPAC2 receptor (vipr2_human)
FAMILY
Class B1 (Secretin) Peptide receptors VIP and PACAP receptors VPAC2 receptor
GENE
VIPR2 (VIP2R)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Vasoactive intestinal polypeptide receptor 2, VIP-R-2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R-3, PACAP-R3, VPAC2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
T
|
L
|
L
|
P
|
P
|
A
|
L
|
L
|
10 |
T
|
C
|
W
|
L
|
L
|
A
|
P
|
V
|
N
|
S
|
20 |
I
|
H
|
P
|
E
|
C
|
R
|
F
|
H
|
L
|
E
|
30 |
I
|
Q
|
E
|
E
|
E
|
T
|
K
|
C
|
A
|
E
|
40 |
L
|
L
|
R
|
S
|
Q
|
T
|
E
|
K
|
H
|
K
|
50 |
A
|
C
|
S
|
G
|
V
|
W
|
D
|
N
|
I
|
T
|
60 |
C
|
W
|
R
|
P
|
A
|
N
|
V
|
G
|
E
|
T
|
70 |
V
|
T
|
V
|
P
|
C
|
P
|
K
|
V
|
F
|
S
|
80 |
N
|
F
|
Y
|
S
|
K
|
A
|
G
|
N
|
I
|
S
|
90 |
K
|
N
|
C
|
T
|
S
|
D
|
G
|
W
|
S
|
E
|
100 |
T
|
F
|
P
|
D
|
F
|
V
|
D
|
A
|
C
|
G
|
110 |
TM1 | |||||||||
Y
|
S
|
D
|
P
|
E
|
D
|
E
|
S
|
K
|
I
|
120 |
T
|
F
|
Y
|
I
|
L
|
V
|
K
|
A
|
I
|
Y
|
130 |
T
|
L
|
G
|
Y
|
S
|
V
|
S
|
L
|
M
|
S
|
140 |
L
|
A
|
T
|
G
|
S
|
I
|
I
|
L
|
C
|
L
|
150 |
ICL1 | TM2 | ||||||||
F
|
R
|
K
|
L
|
H
|
C
|
T
|
R
|
N
|
Y
|
160 |
I
|
H
|
L
|
N
|
L
|
F
|
L
|
S
|
F
|
I
|
170 |
L
|
R
|
A
|
I
|
S
|
V
|
L
|
V
|
K
|
D
|
180 |
ECL1 | |||||||||
D
|
V
|
L
|
Y
|
S
|
S
|
S
|
G
|
T
|
L
|
190 |
H
|
C
|
P
|
D
|
Q
|
P
|
S
|
S
|
W
|
V
|
200 |
TM3 | |||||||||
G
|
C
|
K
|
L
|
S
|
L
|
V
|
F
|
L
|
Q
|
210 |
Y
|
C
|
I
|
M
|
A
|
N
|
F
|
F
|
W
|
L
|
220 |
L
|
V
|
E
|
G
|
L
|
Y
|
L
|
H
|
T
|
L
|
230 |
ICL2 | TM4 | ||||||||
L
|
V
|
A
|
M
|
L
|
P
|
P
|
R
|
R
|
C
|
240 |
F
|
L
|
A
|
Y
|
L
|
L
|
I
|
G
|
W
|
G
|
250 |
L
|
P
|
T
|
V
|
C
|
I
|
G
|
A
|
W
|
T
|
260 |
A
|
A
|
R
|
L
|
Y
|
L
|
E
|
D
|
T
|
G
|
270 |
ECL2 | TM5 | ||||||||
C
|
W
|
D
|
T
|
N
|
D
|
H
|
S
|
V
|
P
|
280 |
W
|
W
|
V
|
I
|
R
|
I
|
P
|
I
|
L
|
I
|
290 |
S
|
I
|
I
|
V
|
N
|
F
|
V
|
L
|
F
|
I
|
300 |
S
|
I
|
I
|
R
|
I
|
L
|
L
|
Q
|
K
|
L
|
310 |
ICL3 | TM6 | ||||||||
T
|
S
|
P
|
D
|
V
|
G
|
G
|
N
|
D
|
Q
|
320 |
S
|
Q
|
Y
|
K
|
R
|
L
|
A
|
K
|
S
|
T
|
330 |
L
|
L
|
L
|
I
|
P
|
L
|
F
|
G
|
V
|
H
|
340 |
Y
|
M
|
V
|
F
|
A
|
V
|
F
|
P
|
I
|
S
|
350 |
ECL3 | TM7 | ||||||||
I
|
S
|
S
|
K
|
Y
|
Q
|
I
|
L
|
F
|
E
|
360 |
L
|
C
|
L
|
G
|
S
|
F
|
Q
|
G
|
L
|
V
|
370 |
H8 | |||||||||
V
|
A
|
V
|
L
|
Y
|
C
|
F
|
L
|
N
|
S
|
380 |
E
|
V
|
Q
|
C
|
E
|
L
|
K
|
R
|
K
|
W
|
390 |
R
|
S
|
R
|
C
|
P
|
T
|
P
|
S
|
A
|
S
|
400 |
C-term | |||||||||
R
|
D
|
Y
|
R
|
V
|
C
|
G
|
S
|
S
|
F
|
410 |
S
|
R
|
N
|
G
|
S
|
E
|
G
|
A
|
L
|
Q
|
420 |
F
|
H
|
R
|
G
|
S
|
R
|
A
|
Q
|
S
|
F
|
430 |
L
|
Q
|
T
|
E
|
T
|
S
|
V
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
VIP, PACAP-38, PACAP-27, GHRH, PHI, secretin
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page