ADGRF1 - Gi1

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WU4

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41586-022-04580-W

PUBLICATION DATE

April 27, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 690 - G.H5 V 339 G.H5.11
Hydrophobic ICL2 F 690 - G.H5 F 336 G.H5.08
Polar ICL3 R 780 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 R 780 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 780 - G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 I 795 6x44 G.H5 G 352 G.H5.24
Hydrophobic ICL3 V 774 - G.H5 D 337 G.H5.09
Hydrophobic TM6 K 791 6x40 G.H5 F 354 G.H5.26
Polar TM2 R 623 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 623 2x46 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 689 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 689 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 777 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 780 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 780 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 L 778 - G.H4 A 301 G.H4.08
Hydrophobic ICL3 V 774 - G.H5 F 334 G.H5.06
Hydrophobic TM5 V 765 5x57 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 765 5x57 G.H5 L 353 G.H5.25
Hydrophobic ICL3 G 775 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 G 775 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 F 690 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 690 - G.S3 L 194 G.S3.01
Hydrophobic TM3 I 686 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 689 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 V 689 - G.H5 T 340 G.H5.12
Polar TM2 R 623 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 623 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 623 2x46 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 689 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 689 - G.H5 I 343 G.H5.15
Polar ICL3 R 777 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 777 - G.S6 I 319 G.S6.01
Polar TM2 T 619 2x42 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 769 5x61 G.H5 L 348 G.H5.20
Ionic ICL3 R 780 - G.H4 E 308 G.H4.16
Polar ICL3 R 780 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 R 780 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 780 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 V 774 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 774 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 E 776 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 E 776 - G.S6 F 323 G.S6.05
Aromatic TM6 R 788 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 788 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 788 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 619 2x42 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 619 2x42 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 769 5x61 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 769 5x61 G.H5 F 354 G.H5.26
Hydrophobic ICL3 R 777 - G.S6 T 321 G.S6.03
Hydrophobic TM3 L 682 3x54 G.H5 L 353 G.H5.25
Polar TM6 S 792 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 792 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 792 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 686 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 686 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 682 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 682 3x54 G.H5 C 351 G.H5.23
Polar TM3 R 685 3x57 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 685 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 685 3x57 G.H5 C 351 G.H5.23
Ionic ICL3 R 777 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 777 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 777 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 777 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 780 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 L 778 - G.H4 C 305 G.H4.13
Hydrophobic TM3 R 685 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 690 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 690 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 690 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 690 - G.H5 T 340 G.H5.12
Hydrophobic TM2 T 619 2x42 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 619 2x42 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 692 - G.hns1 A 31 G.hns1.02