CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7MBX

RESOLUTION

2.0 Å

REFERENCE

10.1371/JOURNAL.PBIO.3001295

PUBLICATION DATE

May 26, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

71 interactions (Click to see)

LIGANDS

CHEMBL216166 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

desulfated cholecystokinin-8, CCK-39, CCK-4, gastrin-17, CCK-8, CCK-33, CCK-58



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Polar H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic H8 K 375 8x48 G.H5 L 393 G.H5.25
Van-der-waals H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM6 M 314 6x36 G.H5 L 393 G.H5.25
Polar H8 K 375 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 375 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 375 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Polar ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Van-der-waals TM6 K 308 6x30 G.H5 L 388 G.H5.20
Hydrophobic H8 R 376 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 146 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 146 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM7 M 373 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 M 373 7x56 G.H5 L 393 G.H5.25
Hydrophobic H8 R 376 8x49 G.H5 Q 390 G.H5.22
Polar TM3 C 144 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 144 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 147 34x51 G.H5 C 379 G.H5.11
Polar ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Ionic TM5 E 235 5x64 G.H5 R 380 G.H5.12
Polar TM5 E 235 5x64 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Polar TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 H 387 G.H5.19
Polar ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic H8 K 375 8x48 G.H5 L 394 G.H5.26
Polar H8 R 378 8x51 G.H5 L 393 G.H5.25
Van-der-waals H8 R 378 8x51 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 V 311 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 147 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 147 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 146 34x50 G.H5 Q 384 G.H5.16
Polar H8 N 374 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 374 8x47 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 R 150 34x54 G.H5 I 383 G.H5.15
Polar ICL3 S 301 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 S 301 - G.h4s6 G 355 G.h4s6.11