H4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

March 20, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 V 120 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Polar H8 H 362 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 H 362 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 308 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 116 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.S3 L 194 G.S3.01
Polar H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 197 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 126 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 125 34x56 G.hns1 R 32 G.hns1.03
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19