FZD7 - Gs

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Aug. 4, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 M 454 5x76 G.H5 L 388 G.H5.20
Hydrophobic TM2 E 286 2x41 G.H5 L 394 G.H5.26
Van-der-waals TM2 E 286 2x41 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 466 6x28 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 466 6x28 G.H5 L 394 G.H5.26
Hydrophobic TM3 W 361 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 W 361 3x50 G.H5 L 394 G.H5.26
Polar TM4 H 371 4x35 G.H5 Y 391 G.H5.23
Polar ICL2 W 369 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 W 369 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 W 369 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 364 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 364 3x53 G.H5 Y 391 G.H5.23
Hydrophobic H8 K 552 8x49 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 450 5x72 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 453 5x75 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 453 5x75 G.H5 Q 384 G.H5.16
Polar TM4 G 370 4x34 G.H5 Y 391 G.H5.23
Hydrophobic TM4 G 370 4x34 G.H5 Y 391 G.H5.23
Van-der-waals TM4 G 370 4x34 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 368 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 368 - G.H5 H 387 G.H5.19
Ionic ICL3 D 457 - G.H5 R 385 G.H5.17
Polar ICL3 D 457 - G.H5 R 385 G.H5.17
Hydrophobic TM6 E 462 6x24 G.H5 E 392 G.H5.24
Van-der-waals TM6 E 462 6x24 G.H5 E 392 G.H5.24
Hydrophobic TM7 W 547 7x55 G.H5 L 394 G.H5.26
Van-der-waals TM7 W 547 7x55 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 454 5x76 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 454 5x76 G.H5 Q 384 G.H5.16