Refined structure (7VH0) of Gi1 - MT2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 273 from structure (80.8%), 65 from model (19.2%)
Residue sidechains - 255 from structure (75.4%), 83 from model (24.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 F - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 C - AF2 AF2
N-term 11 C - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 W - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 V - AF2 AF2
N-term 19 R - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 G - AF2 AF2
N-term 22 W - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 P - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 R - AF2 AF2
N-term 33 T - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 R - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 P - AF2 AF2
TM1 38 W 1.30x30 Structure Structure
TM1 39 V 1.31x31 Structure Structure
TM1 40 A 1.32x32 Structure Structure
TM1 41 P 1.33x33 Structure Structure
TM1 42 A 1.34x34 Structure Structure
TM1 43 L 1.35x35 Structure Structure
TM1 44 S 1.36x36 Structure Structure
TM1 45 A 1.37x37 Structure Structure
TM1 46 V 1.38x38 Structure Structure
TM1 47 L 1.39x39 Structure Structure
TM1 48 I 1.40x40 Structure Structure
TM1 49 V 1.41x41 Structure Structure
TM1 50 T 1.42x42 Structure Structure
TM1 51 T 1.43x43 Structure Structure
TM1 52 A 1.44x44 Structure Structure
TM1 53 V 1.45x45 Structure Structure
TM1 54 D 1.46x46 Structure Structure
TM1 55 V 1.47x47 Structure Structure
TM1 56 V 1.48x48 Structure Structure
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 L 1.51x51 Structure Structure
TM1 60 L 1.52x52 Structure Structure
TM1 61 V 1.53x53 Structure Structure
TM1 62 I 1.54x54 Structure Structure
TM1 63 L 1.55x55 Structure Structure
TM1 64 S 1.56x56 Structure Structure
TM1 65 V 1.57x57 Structure Structure
TM1 66 L 1.58x58 Structure Structure
TM1 67 R 1.59x59 Structure Structure
TM1 68 N 1.60x60 Structure Structure
ICL1 69 R 12.48x48 Structure AF2
ICL1 70 K 12.49x49 Structure AF2
ICL1 71 L 12.50x50 Structure Structure
ICL1 72 R 12.51x51 Structure Structure
TM2 73 N 2.37x37 Structure Structure
TM2 74 A 2.38x38 Structure Structure
TM2 75 G 2.39x39 Structure Structure
TM2 76 N 2.40x40 Structure Structure
TM2 77 L 2.41x41 Structure Structure
TM2 78 F 2.42x42 Structure Structure
TM2 79 L 2.43x43 Structure Structure
TM2 80 V 2.44x44 Structure Structure
TM2 81 S 2.45x45 Structure Structure
TM2 82 L 2.46x46 Structure Structure
TM2 83 A 2.47x47 Structure Structure
TM2 84 L 2.48x48 Structure Structure
TM2 85 A 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure Structure
TM2 87 L 2.51x51 Structure Structure
TM2 88 V 2.52x52 Structure Structure
TM2 89 V 2.53x53 Structure Structure
TM2 90 A 2.54x54 Structure Structure
TM2 91 F 2.55x55 Structure Structure
TM2 92 Y 2.56x551 Structure Structure
TM2 93 P 2.57x56 Structure Structure
TM2 94 Y 2.58x57 Structure Structure
TM2 95 P 2.59x58 Structure Structure
TM2 96 L 2.60x59 Structure Structure
TM2 97 I 2.61x60 Structure Structure
TM2 98 L 2.62x61 Structure Structure
TM2 99 V 2.63x62 Structure Structure
TM2 100 A 2.64x63 Structure Structure
TM2 101 I 2.65x64 Structure Structure
TM2 102 F 2.66x65 Structure Structure
TM2 103 Y 2.67x66 Structure Structure
TM2 104 D 2.68x67 Structure Structure
ECL1 105 G 23.49x49 Structure Structure
ECL1 106 W 23.50x50 Structure Structure
ECL1 107 A 23.51x51 Structure Structure
ECL1 108 L 23.52x52 Structure AF2
TM3 109 G 3.21x21 Structure Structure
TM3 110 E 3.22x22 Structure Structure
TM3 111 E 3.23x23 Structure Structure
TM3 112 H 3.24x24 Structure Structure
TM3 113 C 3.25x25 Structure Structure
TM3 114 K 3.26x26 Structure AF2
TM3 115 A 3.27x27 Structure Structure
TM3 116 S 3.28x28 Structure Structure
TM3 117 A 3.29x29 Structure Structure
TM3 118 F 3.30x30 Structure Structure
TM3 119 V 3.31x31 Structure Structure
TM3 120 M 3.32x32 Structure Structure
TM3 121 G 3.33x33 Structure Structure
TM3 122 L 3.34x34 Structure Structure
TM3 123 S 3.35x35 Structure Structure
TM3 124 V 3.36x36 Structure Structure
TM3 125 I 3.37x37 Structure Structure
TM3 126 G 3.38x38 Structure Structure
TM3 127 S 3.39x39 Structure Structure
TM3 128 V 3.40x40 Structure Structure
TM3 129 F 3.41x41 Structure AF2
TM3 130 N 3.42x42 Structure Structure
TM3 131 I 3.43x43 Structure Structure
TM3 132 T 3.44x44 Structure Structure
TM3 133 A 3.45x45 Structure Structure
TM3 134 I 3.46x46 Structure Structure
TM3 135 A 3.47x47 Structure Structure
TM3 136 I 3.48x48 Structure Structure
TM3 137 N 3.49x49 Structure Structure
TM3 138 R 3.50x50 Structure Structure
TM3 139 Y 3.51x51 Structure Structure
TM3 140 C 3.52x52 Structure AF2
TM3 141 Y 3.53x53 Structure Structure
TM3 142 I 3.54x54 Structure Structure
TM3 143 C 3.55x55 Structure Structure
TM3 144 H 3.56x56 Structure Structure
ICL2 145 S 34.50x50 Structure Structure
ICL2 146 M 34.51x51 Structure Structure
ICL2 147 A 34.52x52 Structure Structure
ICL2 148 Y 34.53x53 Structure Structure
ICL2 149 H 34.54x54 Structure Structure
ICL2 150 R 34.55x55 Structure AF2
ICL2 151 I 34.56x56 Structure Structure
ICL2 152 Y 34.57x57 Structure Structure
TM4 153 R 4.38x38 Structure AF2
TM4 154 R 4.39x39 Structure Structure
TM4 155 W 4.40x40 Structure Structure
TM4 156 H 4.41x41 Structure Structure
TM4 157 T 4.42x42 Structure Structure
TM4 158 P 4.43x43 Structure Structure
TM4 159 L 4.44x44 Structure Structure
TM4 160 H 4.45x45 Structure Structure
TM4 161 I 4.46x46 Structure Structure
TM4 162 C 4.47x47 Structure Structure
TM4 163 L 4.48x48 Structure Structure
TM4 164 I 4.49x49 Structure Structure
TM4 165 W 4.50x50 Structure Structure
TM4 166 L 4.51x51 Structure Structure
TM4 167 L 4.52x52 Structure Structure
TM4 168 T 4.53x53 Structure Structure
TM4 169 V 4.54x54 Structure Structure
TM4 170 V 4.55x55 Structure Structure
TM4 171 A 4.56x56 Structure Structure
TM4 172 L 4.57x57 Structure Structure
TM4 173 L 4.58x59 Structure Structure
TM4 174 P 4.59x60 Structure Structure
TM4 175 N 4.60x61 Structure Structure
TM4 176 F 4.61x62 Structure AF2
TM4 177 F 4.62x63 Structure Structure
TM4 178 V 4.63x64 Structure Structure
TM4 179 G 4.64x65 Structure Structure
ECL2 180 S - Structure Structure
ECL2 181 L - Structure Structure
ECL2 182 E - Structure AF2
ECL2 183 Y - Structure Structure
ECL2 184 D - Structure Structure
ECL2 185 P - Structure Structure
ECL2 186 R - Structure Structure
ECL2 187 I - Structure Structure
ECL2 188 Y - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 C 45.50x50 Structure Structure
ECL2 191 T 45.51x51 Structure Structure
ECL2 192 F 45.52x52 Structure Structure
ECL2 193 I - Structure Structure
ECL2 194 Q - Structure Structure
ECL2 195 T - Structure Structure
ECL2 196 A - Structure Structure
TM5 197 S 5.35x36 Structure Structure
TM5 198 T 5.36x37 Structure Structure
TM5 199 Q 5.37x38 Structure AF2
TM5 200 Y 5.38x39 Structure Structure
TM5 201 T 5.39x40 Structure Structure
TM5 202 A 5.40x41 Structure Structure
TM5 203 A 5.41x42 Structure Structure
TM5 204 V 5.42x43 Structure Structure
TM5 205 V 5.43x44 Structure Structure
TM5 206 V 5.44x45 Structure Structure
TM5 207 I 5.45x46 Structure Structure
TM5 208 H 5.46x461 Structure Structure
TM5 209 F 5.47x47 Structure Structure
TM5 210 L 5.48x48 Structure Structure
TM5 211 L 5.49x49 Structure Structure
TM5 212 P 5.50x50 Structure Structure
TM5 213 I 5.51x51 Structure Structure
TM5 214 A 5.52x52 Structure Structure
TM5 215 V 5.53x53 Structure Structure
TM5 216 V 5.54x54 Structure Structure
TM5 217 S 5.55x55 Structure Structure
TM5 218 F 5.56x56 Structure Structure
TM5 219 C 5.57x57 Structure Structure
TM5 220 Y 5.58x58 Structure Structure
TM5 221 L 5.59x59 Structure Structure
TM5 222 R 5.60x60 Structure AF2
TM5 223 I 5.61x61 Structure Structure
TM5 224 W 5.62x62 Structure Structure
TM5 225 V 5.63x63 Structure Structure
TM5 226 L 5.64x64 Structure Structure
TM5 227 V 5.65x65 Structure Structure
TM5 228 L 5.66x66 Structure Structure
TM5 229 Q 5.67x67 Structure Structure
TM5 230 A 5.68x68 Structure Structure
TM5 231 R 5.69x69 Structure Structure
TM5 232 R 5.70x70 Structure Structure
TM5 233 K 5.71x71 Structure Structure
TM5 234 A 5.72x72 Structure Structure
ICL3 235 K - Structure Structure
ICL3 236 P - AF2 AF2
ICL3 237 E - AF2 AF2
ICL3 238 S - AF2 AF2
ICL3 239 R - AF2 AF2
TM6 240 L 6.24x24 AF2 AF2
TM6 241 C 6.25x25 AF2 AF2
TM6 242 L 6.26x26 AF2 AF2
TM6 243 K 6.27x27 AF2 AF2
TM6 244 P 6.28x28 AF2 AF2
TM6 245 S 6.29x29 AF2 AF2
TM6 246 D 6.30x30 AF2 AF2
TM6 247 L 6.31x31 AF2 AF2
TM6 248 R 6.32x32 AF2 AF2
TM6 249 S 6.33x33 Structure Structure
TM6 250 F 6.34x34 Structure Structure
TM6 251 L 6.35x35 Structure Structure
TM6 252 T 6.36x36 Structure Structure
TM6 253 M 6.37x37 Structure Structure
TM6 254 F 6.38x38 Structure Structure
TM6 255 V 6.39x39 Structure Structure
TM6 256 V 6.40x40 Structure Structure
TM6 257 F 6.41x41 Structure Structure
TM6 258 V 6.42x42 Structure Structure
TM6 259 I 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 A 6.45x45 Structure Structure
TM6 262 I 6.46x46 Structure Structure
TM6 263 C 6.47x47 Structure Structure
TM6 264 W 6.48x48 Structure Structure
TM6 265 A 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 L 6.51x51 Structure Structure
TM6 268 N 6.52x52 Structure Structure
TM6 269 C 6.53x53 Structure Structure
TM6 270 I 6.54x54 Structure Structure
TM6 271 G 6.55x55 Structure Structure
TM6 272 L 6.56x56 Structure Structure
TM6 273 A 6.57x57 Structure Structure
TM6 274 V 6.58x58 Structure Structure
TM6 275 A 6.59x59 Structure Structure
TM6 276 I 6.60x60 Structure Structure
TM6 277 N 6.61x61 Structure AF2
ECL3 278 P - Structure Structure
ECL3 279 Q - Structure Structure
ECL3 280 E - Structure Structure
ECL3 281 M - Structure Structure
ECL3 282 A - Structure Structure
ECL3 283 P - Structure Structure
ECL3 284 Q - Structure AF2
ECL3 285 I - Structure AF2
TM7 286 P 7.31x30 Structure Structure
TM7 287 E 7.32x31 Structure Structure
TM7 288 G 7.33x32 Structure Structure
TM7 289 L 7.34x33 Structure Structure
TM7 290 F 7.35x34 Structure Structure
TM7 291 V 7.36x35 Structure Structure
TM7 292 T 7.37x36 Structure Structure
TM7 293 S 7.38x37 Structure Structure
TM7 294 Y 7.39x38 Structure Structure
TM7 295 L 7.40x39 Structure Structure
TM7 296 L 7.41x40 Structure Structure
TM7 297 A 7.42x41 Structure Structure
TM7 298 Y 7.43x42 Structure Structure
TM7 299 F 7.44x43 Structure Structure
TM7 300 N 7.45x45 Structure Structure
TM7 301 S 7.46x46 Structure Structure
TM7 302 C 7.47x47 Structure Structure
TM7 303 L 7.48x48 Structure Structure
TM7 304 N 7.49x49 Structure Structure
TM7 305 A 7.50x50 Structure Structure
TM7 306 I 7.51x51 Structure Structure
TM7 307 V 7.52x52 Structure Structure
TM7 308 Y 7.53x53 Structure Structure
TM7 309 G 7.54x54 Structure Structure
TM7 310 L 7.55x55 Structure Structure
TM7 311 L 7.56x56 Structure Structure
H8 312 N 8.47x47 Structure Structure
H8 313 Q 8.48x48 Structure AF2
H8 314 N 8.49x49 Structure Structure
H8 315 F 8.50x50 Structure Structure
H8 316 R 8.51x51 Structure Structure
H8 317 R 8.52x52 Structure Structure
H8 318 E 8.53x53 Structure Structure
H8 319 Y 8.54x54 Structure Structure
H8 320 K 8.55x55 Structure AF2
H8 321 R 8.56x56 Structure AF2
H8 322 I 8.57x57 Structure Structure
H8 323 L 8.58x58 Structure Structure
H8 324 L 8.59x59 AF2 AF2
H8 325 A 8.60x60 AF2 AF2
H8 326 L 8.61x61 AF2 AF2
H8 327 W 8.62x62 AF2 AF2
H8 328 N 8.63x63 AF2 AF2
C-term 329 P - AF2 AF2
C-term 330 R - AF2 AF2
C-term 331 H - AF2 AF2
C-term 332 C - AF2 AF2
C-term 333 I - AF2 AF2
C-term 334 Q - AF2 AF2
C-term 335 D - AF2 AF2
C-term 336 A - AF2 AF2
C-term 337 S - AF2 AF2
C-term 338 K - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Van-der-waals H8 N 312 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 240 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 L 240 6x24 G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 227 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Polar ICL3 K 235 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 K 235 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 K 235 - G.S6 H 322 G.S6.04
Hydrophobic TM6 K 243 6x27 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 I 142 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 C 351 G.H5.23
Polar ICL3 K 235 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 K 235 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 K 235 - G.S6 T 321 G.S6.03
Polar TM6 F 250 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 F 250 6x34 G.H5 F 354 G.H5.26
Van-der-waals TM6 F 250 6x34 G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 235 - G.H5 F 334 G.H5.06
Hydrophobic H8 Q 313 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 313 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 250 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 250 6x34 G.H5 L 348 G.H5.20
Ionic TM4 R 153 4x38 G.HN E 28 G.HN.52
Polar TM4 R 153 4x38 G.HN E 28 G.HN.52
Polar ICL2 H 149 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 149 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM4 R 154 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 R 154 4x39 G.HN R 24 G.HN.48
Ionic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 A 234 5x72 G.S6 Y 320 G.S6.02
Polar TM6 F 250 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 250 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 250 6x34 G.H5 L 353 G.H5.25
Polar TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 K 233 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 V 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 R 231 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 231 5x69 G.H5 K 345 G.H5.17
Polar TM3 Y 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 S 249 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 249 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 240 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 L 240 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 142 3x54 G.H5 N 347 G.H5.19