FPR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EUO

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-022-32822-Y

PUBLICATION DATE

May 25, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

34 interactions (Click to see)

LIGANDS

Peptide Agonist fMLF - Agonist

PHYSIOLOGICAL LIGANDS

annexin I, fMet-Leu-Phe, spinorphin, cathepsin G



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 130 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 130 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 134 - G.H5 I 343 G.H5.15
Polar TM6 R 238 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 131 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 130 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 K 235 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 K 235 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 130 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 130 - G.H5 T 340 G.H5.12
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Polar TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 242 6x36 G.H5 L 353 G.H5.25
Polar ICL2 N 135 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 - G.s2s3 D 193 G.s2s3.02
Ionic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 N 135 - G.hns1 R 32 G.hns1.03
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x37 G.H5 L 353 G.H5.25
Polar TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL3 K 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 235 - G.H5 F 354 G.H5.26
Polar ICL2 T 133 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 134 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 233 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 233 - G.H5 I 344 G.H5.16