S1P3 receptor (s1pr3_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P3 receptor
GENE
S1PR3 (C9orf108, C9orf47)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Sphingosine 1-phosphate receptor 3, S1P receptor 3, S1P3, Endothelial differentiation G-protein coupled receptor 3, Sphingosine 1-phosphate receptor Edg-3, S1P receptor Edg-3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
T
|
A
|
L
|
P
|
P
|
R
|
L
|
Q
|
10 |
P
|
V
|
R
|
G
|
N
|
E
|
T
|
L
|
R
|
E
|
20 |
H
|
Y
|
Q
|
Y
|
V
|
G
|
K
|
L
|
A
|
G
|
30 |
R
|
L
|
K
|
E
|
A
|
S
|
E
|
G
|
S
|
T
|
40 |
TM1 | |||||||||
L
|
T
|
T
|
V
|
L
|
F
|
L
|
V
|
I
|
C
|
50 |
S
|
F
|
I
|
V
|
L
|
E
|
N
|
L
|
M
|
V
|
60 |
L
|
I
|
A
|
I
|
W
|
K
|
N
|
N
|
K
|
F
|
70 |
ICL1 | TM2 | ||||||||
H
|
N
|
R
|
M
|
Y
|
F
|
F
|
I
|
G
|
N
|
80 |
L
|
A
|
L
|
C
|
D
|
L
|
L
|
A
|
G
|
I
|
90 |
A
|
Y
|
K
|
V
|
N
|
I
|
L
|
M
|
S
|
G
|
100 |
ECL1 | TM3 | ||||||||
K
|
K
|
T
|
F
|
S
|
L
|
S
|
P
|
T
|
V
|
110 |
W
|
F
|
L
|
R
|
E
|
G
|
S
|
M
|
F
|
V
|
120 |
A
|
L
|
G
|
A
|
S
|
T
|
C
|
S
|
L
|
L
|
130 |
A
|
I
|
A
|
I
|
E
|
R
|
H
|
L
|
T
|
M
|
140 |
ICL2 | |||||||||
I
|
K
|
M
|
R
|
P
|
Y
|
D
|
A
|
N
|
K
|
150 |
TM4 | |||||||||
R
|
H
|
R
|
V
|
F
|
L
|
L
|
I
|
G
|
M
|
160 |
C
|
W
|
L
|
I
|
A
|
F
|
T
|
L
|
G
|
A
|
170 |
ECL2 | |||||||||
L
|
P
|
I
|
L
|
G
|
W
|
N
|
C
|
L
|
H
|
180 |
N
|
L
|
P
|
D
|
C
|
S
|
T
|
I
|
L
|
P
|
190 |
TM5 | |||||||||
L
|
Y
|
S
|
K
|
K
|
Y
|
I
|
A
|
F
|
C
|
200 |
I
|
S
|
I
|
F
|
T
|
A
|
I
|
L
|
V
|
T
|
210 |
I
|
V
|
I
|
L
|
Y
|
A
|
R
|
I
|
Y
|
F
|
220 |
L
|
V
|
K
|
S
|
S
|
S
|
R
|
K
|
V
|
A
|
230 |
TM6 | |||||||||
N
|
H
|
N
|
N
|
S
|
E
|
R
|
S
|
M
|
A
|
240 |
L
|
L
|
R
|
T
|
V
|
V
|
I
|
V
|
V
|
S
|
250 |
V
|
F
|
I
|
A
|
C
|
W
|
S
|
P
|
L
|
F
|
260 |
I
|
L
|
F
|
L
|
I
|
D
|
V
|
A
|
C
|
R
|
270 |
ECL3 | TM7 | ||||||||
V
|
Q
|
A
|
C
|
P
|
I
|
L
|
F
|
K
|
A
|
280 |
Q
|
W
|
F
|
I
|
V
|
L
|
A
|
V
|
L
|
N
|
290 |
S
|
A
|
M
|
N
|
P
|
V
|
I
|
Y
|
T
|
L
|
300 |
H8 | |||||||||
A
|
S
|
K
|
E
|
M
|
R
|
R
|
A
|
F
|
F
|
310 |
C-term | |||||||||
R
|
L
|
V
|
C
|
N
|
C
|
L
|
V
|
R
|
G
|
320 |
R
|
G
|
A
|
R
|
A
|
S
|
P
|
I
|
Q
|
P
|
330 |
A
|
L
|
D
|
P
|
S
|
R
|
S
|
K
|
S
|
S
|
340 |
S
|
S
|
N
|
N
|
S
|
S
|
H
|
S
|
P
|
K
|
350 |
V
|
K
|
E
|
D
|
L
|
P
|
H
|
T
|
A
|
P
|
360 |
S
|
S
|
C
|
I
|
M
|
D
|
K
|
N
|
A
|
A
|
370 |
L
|
Q
|
N
|
G
|
I
|
F
|
C
|
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosylphosphorylcholine, sphingosine 1-phosphate, dihydrosphingosine 1-phosphate
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page