S1P3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EW4

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-021-00567-W

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

CYM-5541 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 145 - G.S1 E 33 G.S1.01
Hydrophobic ICL2 P 145 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 Y 146 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 Y 146 - G.S1 E 33 G.S1.01
Hydrophobic TM5 S 225 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 225 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 241 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 241 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 222 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 237 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 145 - G.hns1 R 32 G.hns1.03
Polar TM2 N 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 143 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 M 143 - G.H5 I 344 G.H5.16
Van-der-waals TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 N 233 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM2 M 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 237 6x29 G.H5 L 348 G.H5.20
Polar ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 144 - G.H5 I 343 G.H5.15
Polar ICL2 Y 146 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 Y 146 - G.h2s4 G 217 G.h2s4.03
Hydrophobic TM3 M 140 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 140 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 V 229 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 229 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 237 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 237 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 146 - G.S1 K 35 G.S1.03
Van-der-waals ICL2 Y 146 - G.S1 K 35 G.S1.03
Hydrophobic TM3 M 140 3x54 G.H5 I 344 G.H5.16
Polar TM6 N 233 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 N 233 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 S 302 8x47 G.H5 G 352 G.H5.24
Polar TM3 T 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 V 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 229 - G.H5 D 341 G.H5.13
Hydrophobic TM3 T 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic TM3 M 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 222 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 Y 215 5x58 G.H5 L 353 G.H5.25
Ionic TM6 R 237 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 237 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 237 6x29 G.H5 D 341 G.H5.13
Polar TM3 R 136 3x50 G.H5 G 352 G.H5.24
Polar ICL2 Y 146 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 R 144 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 K 228 - G.H5 D 337 G.H5.09
Hydrophobic TM5 L 221 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 148 - G.HN E 28 G.HN.52
Hydrophobic TM3 M 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 143 - G.H5 I 343 G.H5.15
Van-der-waals TM6 N 233 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 234 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 240 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 240 6x32 G.H5 F 354 G.H5.26
Polar ICL2 K 142 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 142 - G.H5 N 347 G.H5.19