Refined structure (7TUZ) of Gi1 - GPR183

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (64.1%), 127 from model (35.9%)
Residue sidechains - 224 from structure (63.3%), 130 from model (36.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (84.8%), 51 from model (15.2%)
Residue sidechains - 269 from structure (80.3%), 66 from model (19.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 I - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 M - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 F - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 Q - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 N - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 C - AF2 AF2
N-term 22 D - Structure Structure
N-term 23 L - Structure Structure
N-term 24 Y - Structure Structure
N-term 25 A - Structure Structure
TM1 26 H 1.27x27 Structure Structure
TM1 27 H 1.28x28 Structure Structure
TM1 28 S 1.29x29 Structure Structure
TM1 29 T 1.30x30 Structure Structure
TM1 30 A 1.31x31 Structure Structure
TM1 31 R 1.32x32 Structure Structure
TM1 32 I 1.33x33 Structure Structure
TM1 33 V 1.34x34 Structure Structure
TM1 34 M 1.35x35 Structure Structure
TM1 35 P 1.36x36 Structure Structure
TM1 36 L 1.37x37 Structure Structure
TM1 37 H 1.38x38 Structure Structure
TM1 38 Y 1.39x39 Structure Structure
TM1 39 S 1.40x40 Structure Structure
TM1 40 L 1.41x41 Structure Structure
TM1 41 V 1.42x42 Structure Structure
TM1 42 F 1.43x43 Structure Structure
TM1 43 I 1.44x44 Structure Structure
TM1 44 I 1.45x45 Structure Structure
TM1 45 G 1.46x46 Structure Structure
TM1 46 L 1.47x47 Structure Structure
TM1 47 V 1.48x48 Structure Structure
TM1 48 G 1.49x49 Structure Structure
TM1 49 N 1.50x50 Structure Structure
TM1 50 L 1.51x51 Structure Structure
TM1 51 L 1.52x52 Structure Structure
TM1 52 A 1.53x53 Structure Structure
TM1 53 L 1.54x54 Structure Structure
TM1 54 V 1.55x55 Structure Structure
TM1 55 V 1.56x56 Structure Structure
TM1 56 I 1.57x57 Structure Structure
TM1 57 V 1.58x58 Structure Structure
TM1 58 Q 1.59x59 Structure AF2
TM1 59 N 1.60x60 Structure AF2
ICL1 60 R 12.48x48 Structure AF2
ICL1 61 K 12.49x49 Structure AF2
ICL1 62 K 12.50x50 Structure AF2
ICL1 63 I 12.51x51 Structure AF2
TM2 64 N 2.37x37 Structure Structure
TM2 65 S 2.38x38 Structure Structure
TM2 66 T 2.39x39 Structure Structure
TM2 67 T 2.40x40 Structure Structure
TM2 68 L 2.41x41 Structure Structure
TM2 69 Y 2.42x42 Structure Structure
TM2 70 S 2.43x43 Structure Structure
TM2 71 T 2.44x44 Structure Structure
TM2 72 N 2.45x45 Structure Structure
TM2 73 L 2.46x46 Structure Structure
TM2 74 V 2.47x47 Structure Structure
TM2 75 I 2.48x48 Structure Structure
TM2 76 S 2.49x49 Structure Structure
TM2 77 D 2.50x50 Structure Structure
TM2 78 I 2.51x51 Structure Structure
TM2 79 L 2.52x52 Structure Structure
TM2 80 F 2.53x53 Structure Structure
TM2 81 T 2.54x54 Structure Structure
TM2 82 T 2.55x55 Structure Structure
TM2 83 A 2.56x56 Structure Structure
TM2 84 L 2.57x57 Structure Structure
TM2 85 P 2.58x58 Structure Structure
TM2 86 T 2.59x59 Structure Structure
TM2 87 R 2.60x60 Structure Structure
TM2 88 I 2.61x61 Structure Structure
TM2 89 A 2.62x62 Structure Structure
TM2 90 Y 2.63x63 Structure Structure
TM2 91 Y 2.64x64 Structure Structure
TM2 92 A 2.65x65 Structure Structure
TM2 93 M 2.66x66 Structure Structure
TM2 94 G 2.67x67 AF2 AF2
ECL1 95 F - AF2 AF2
ECL1 96 D 23.49x49 AF2 AF2
ECL1 97 W 23.50x50 AF2 AF2
ECL1 98 R 23.51x51 AF2 AF2
ECL1 99 I 23.52x52 AF2 AF2
TM3 100 G 3.21x21 Structure Structure
TM3 101 D 3.22x22 Structure AF2
TM3 102 A 3.23x23 Structure Structure
TM3 103 L 3.24x24 Structure Structure
TM3 104 C 3.25x25 Structure Structure
TM3 105 R 3.26x26 Structure AF2
TM3 106 I 3.27x27 Structure Structure
TM3 107 T 3.28x28 Structure Structure
TM3 108 A 3.29x29 Structure Structure
TM3 109 L 3.30x30 Structure Structure
TM3 110 V 3.31x31 Structure Structure
TM3 111 F 3.32x32 Structure Structure
TM3 112 Y 3.33x33 Structure Structure
TM3 113 I 3.34x34 Structure Structure
TM3 114 N 3.35x35 Structure Structure
TM3 115 T 3.36x36 Structure Structure
TM3 116 Y 3.37x37 Structure Structure
TM3 117 A 3.38x38 Structure Structure
TM3 118 G 3.39x39 Structure Structure
TM3 119 V 3.40x40 Structure Structure
TM3 120 N 3.41x41 Structure Structure
TM3 121 F 3.42x42 Structure Structure
TM3 122 M 3.43x43 Structure Structure
TM3 123 T 3.44x44 Structure Structure
TM3 124 C 3.45x45 Structure Structure
TM3 125 L 3.46x46 Structure Structure
TM3 126 S 3.47x47 Structure Structure
TM3 127 I 3.48x48 Structure Structure
TM3 128 D 3.49x49 Structure Structure
TM3 129 R 3.50x50 Structure Structure
TM3 130 F 3.51x51 Structure Structure
TM3 131 I 3.52x52 Structure Structure
TM3 132 A 3.53x53 Structure Structure
TM3 133 V 3.54x54 Structure Structure
TM3 134 V 3.55x55 Structure Structure
TM3 135 H 3.56x56 Structure Structure
ICL2 136 P 34.50x50 Structure Structure
ICL2 137 L 34.51x51 Structure Structure
ICL2 138 R 34.52x52 Structure Structure
ICL2 139 Y 34.53x53 Structure Structure
ICL2 140 N 34.54x54 Structure Structure
ICL2 141 K 34.55x55 Structure Structure
ICL2 142 I 34.56x56 Structure Structure
ICL2 143 K 34.57x57 Structure AF2
TM4 144 R 4.38x38 Structure Structure
TM4 145 I 4.39x39 Structure Structure
TM4 146 E 4.40x40 Structure AF2
TM4 147 H 4.41x41 Structure Structure
TM4 148 A 4.42x42 Structure Structure
TM4 149 K 4.43x43 Structure Structure
TM4 150 G 4.44x44 Structure Structure
TM4 151 V 4.45x45 Structure Structure
TM4 152 C 4.46x46 Structure Structure
TM4 153 I 4.47x47 Structure Structure
TM4 154 F 4.48x48 Structure Structure
TM4 155 V 4.49x49 Structure Structure
TM4 156 W 4.50x50 Structure Structure
TM4 157 I 4.51x51 Structure Structure
TM4 158 L 4.52x52 Structure Structure
TM4 159 V 4.53x53 Structure Structure
TM4 160 F 4.54x54 Structure Structure
TM4 161 A 4.55x55 Structure Structure
TM4 162 Q 4.56x56 Structure Structure
TM4 163 T 4.57x57 Structure Structure
TM4 164 L 4.58x59 Structure Structure
TM4 165 P 4.59x60 Structure Structure
TM4 166 L 4.60x61 Structure Structure
TM4 167 L 4.61x62 Structure Structure
TM4 168 I 4.62x63 Structure Structure
TM4 169 N 4.63x64 Structure Structure
TM4 170 P 4.64x65 Structure Structure
ECL2 171 M - Structure Structure
ECL2 172 S - Structure Structure
ECL2 173 K - Structure Structure
ECL2 174 Q - AF2 AF2
ECL2 175 E - AF2 AF2
ECL2 176 A - AF2 AF2
ECL2 177 E - AF2 AF2
ECL2 178 R - AF2 AF2
ECL2 179 I - Structure Structure
ECL2 180 T - Structure Structure
ECL2 181 C 45.50x50 Structure Structure
ECL2 182 M 45.51x51 Structure Structure
ECL2 183 E 45.52x52 Structure Structure
ECL2 184 Y - Structure Structure
ECL2 185 P - Structure Structure
ECL2 186 N - Structure Structure
ECL2 187 F - Structure Structure
ECL2 188 E - Structure Structure
ECL2 189 E - Structure Structure
ECL2 190 T - Structure AF2
ECL2 191 K - Structure AF2
TM5 192 S 5.34x35 Structure Structure
TM5 193 L 5.35x36 Structure Structure
TM5 194 P 5.36x37 Structure Structure
TM5 195 W 5.37x38 Structure Structure
TM5 196 I 5.38x39 Structure Structure
TM5 197 L 5.39x40 Structure Structure
TM5 198 L 5.40x41 Structure Structure
TM5 199 G 5.41x42 Structure Structure
TM5 200 A 5.42x43 Structure Structure
TM5 201 C 5.43x44 Structure Structure
TM5 202 F 5.44x45 Structure Structure
TM5 203 I 5.45x46 Structure Structure
TM5 204 G 5.46x461 Structure Structure
TM5 205 Y 5.47x47 Structure Structure
TM5 206 V 5.48x48 Structure Structure
TM5 207 L 5.49x49 Structure Structure
TM5 208 P 5.50x50 Structure Structure
TM5 209 L 5.51x51 Structure Structure
TM5 210 I 5.52x52 Structure Structure
TM5 211 I 5.53x53 Structure Structure
TM5 212 I 5.54x54 Structure Structure
TM5 213 L 5.55x55 Structure Structure
TM5 214 I 5.56x56 Structure Structure
TM5 215 C 5.57x57 Structure Structure
TM5 216 Y 5.58x58 Structure Structure
TM5 217 S 5.59x59 Structure Structure
TM5 218 Q 5.60x60 Structure Structure
TM5 219 I 5.61x61 Structure Structure
TM5 220 C 5.62x62 Structure Structure
TM5 221 C 5.63x63 Structure Structure
TM5 222 K 5.64x64 Structure Structure
TM5 223 L 5.65x65 Structure Structure
TM5 224 F 5.66x66 Structure Structure
TM5 225 R 5.67x67 Structure Structure
TM5 226 T 5.68x68 Structure Structure
TM5 227 A 5.69x69 Structure Structure
TM5 228 K 5.70x70 Structure Structure
TM5 229 Q 5.71x71 Structure Structure
TM5 230 N 5.72x72 Structure Structure
ICL3 231 P - Structure Structure
ICL3 232 L - Structure Structure
ICL3 233 T - Structure Structure
ICL3 234 E - Structure AF2
ICL3 235 K - Structure AF2
ICL3 236 S - Structure Structure
TM6 237 G 6.28x28 Structure Structure
TM6 238 V 6.29x29 Structure AF2
TM6 239 N 6.30x30 Structure Structure
TM6 240 K 6.31x31 Structure Structure
TM6 241 K 6.32x32 Structure Structure
TM6 242 A 6.33x33 Structure Structure
TM6 243 L 6.34x34 Structure Structure
TM6 244 N 6.35x35 Structure Structure
TM6 245 T 6.36x36 Structure Structure
TM6 246 I 6.37x37 Structure Structure
TM6 247 I 6.38x38 Structure Structure
TM6 248 L 6.39x39 Structure Structure
TM6 249 I 6.40x40 Structure Structure
TM6 250 I 6.41x41 Structure Structure
TM6 251 V 6.42x42 Structure Structure
TM6 252 V 6.43x43 Structure Structure
TM6 253 F 6.44x44 Structure Structure
TM6 254 V 6.45x45 Structure Structure
TM6 255 L 6.46x46 Structure Structure
TM6 256 C 6.47x47 Structure Structure
TM6 257 F 6.48x48 Structure Structure
TM6 258 T 6.49x49 Structure Structure
TM6 259 P 6.50x50 Structure Structure
TM6 260 Y 6.51x51 Structure Structure
TM6 261 H 6.52x52 Structure Structure
TM6 262 V 6.53x53 Structure Structure
TM6 263 A 6.54x54 Structure Structure
TM6 264 I 6.55x55 Structure Structure
TM6 265 I 6.56x56 Structure Structure
TM6 266 Q 6.57x57 Structure Structure
TM6 267 H 6.58x58 Structure Structure
TM6 268 M 6.59x59 Structure Structure
TM6 269 I 6.60x60 Structure Structure
TM6 270 K 6.61x61 Structure Structure
TM6 271 K 6.62x62 Structure Structure
TM6 272 L 6.63x63 Structure Structure
TM6 273 R 6.64x64 Structure Structure
TM6 274 F 6.65x65 Structure Structure
ECL3 275 S - Structure Structure
ECL3 276 N - Structure Structure
ECL3 277 F - Structure Structure
ECL3 278 L - Structure Structure
ECL3 279 E - Structure Structure
ECL3 280 C - Structure Structure
TM7 281 S 7.26x25 Structure Structure
TM7 282 Q 7.27x26 Structure Structure
TM7 283 R 7.28x27 Structure Structure
TM7 284 H 7.29x28 Structure Structure
TM7 285 S 7.30x29 Structure Structure
TM7 286 F 7.31x30 Structure Structure
TM7 287 Q 7.32x31 Structure Structure
TM7 288 I 7.33x32 Structure Structure
TM7 289 S 7.34x33 Structure Structure
TM7 290 L 7.35x34 Structure Structure
TM7 291 H 7.36x35 Structure Structure
TM7 292 F 7.37x36 Structure Structure
TM7 293 T 7.38x37 Structure Structure
TM7 294 V 7.39x38 Structure Structure
TM7 295 C 7.40x39 Structure Structure
TM7 296 L 7.41x40 Structure Structure
TM7 297 M 7.42x41 Structure Structure
TM7 298 N 7.43x42 Structure Structure
TM7 299 F 7.44x43 Structure Structure
TM7 300 N 7.45x45 Structure Structure
TM7 301 C 7.46x46 Structure Structure
TM7 302 C 7.47x47 Structure Structure
TM7 303 M 7.48x48 Structure Structure
TM7 304 D 7.49x49 Structure Structure
TM7 305 P 7.50x50 Structure Structure
TM7 306 F 7.51x51 Structure Structure
TM7 307 I 7.52x52 Structure Structure
TM7 308 Y 7.53x53 Structure Structure
TM7 309 F 7.54x54 Structure Structure
TM7 310 F 7.55x55 Structure Structure
TM7 311 A 7.56x56 Structure Structure
H8 312 C 8.47x47 Structure Structure
H8 313 K 8.48x48 Structure Structure
H8 314 G 8.49x49 Structure Structure
H8 315 Y 8.50x50 Structure Structure
H8 316 K 8.51x51 Structure Structure
H8 317 R 8.52x52 AF2 AF2
H8 318 K 8.53x53 AF2 AF2
H8 319 V 8.54x54 AF2 AF2
H8 320 M 8.55x55 AF2 AF2
H8 321 R 8.56x56 AF2 AF2
H8 322 M 8.57x57 AF2 AF2
H8 323 L 8.58x58 AF2 AF2
H8 324 K 8.59x59 AF2 AF2
H8 325 R 8.60x60 AF2 AF2
C-term 326 Q - AF2 AF2
C-term 327 V - AF2 AF2
C-term 328 S - AF2 AF2
C-term 329 V - AF2 AF2
C-term 330 S - AF2 AF2
C-term 331 I - AF2 AF2
C-term 332 S - AF2 AF2
C-term 333 S - AF2 AF2
C-term 334 A - AF2 AF2
C-term 335 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 232 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 L 232 - G.H5 A 338 G.H5.10
Hydrophobic TM4 R 144 4x38 G.HN R 24 G.HN.48
Hydrophobic H8 K 313 8x48 G.H5 K 345 G.H5.17
Van-der-waals H8 K 313 8x48 G.H5 K 345 G.H5.17
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM7 A 311 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 A 311 7x56 G.H5 L 353 G.H5.25
Hydrophobic H8 K 313 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 K 313 8x48 G.H5 K 349 G.H5.21
Polar TM5 N 230 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 N 230 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 R 129 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 129 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 133 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 133 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 232 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 232 - G.H5 D 337 G.H5.09
Hydrophobic TM5 I 219 5x61 G.H5 L 353 G.H5.25
Polar H8 K 313 8x48 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 V 238 6x29 G.H5 K 345 G.H5.17
Polar H8 C 312 8x47 G.H5 G 352 G.H5.24
Ionic TM4 R 144 4x38 G.HN E 28 G.HN.52
Polar TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 144 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL3 L 232 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 232 - G.H5 F 334 G.H5.06
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 P 231 - G.H5 D 337 G.H5.09
Hydrophobic TM6 I 246 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 246 6x37 G.H5 L 353 G.H5.25
Polar TM7 A 311 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 A 311 7x56 G.H5 F 354 G.H5.26
Polar TM2 N 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 238 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 238 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Polar TM6 T 245 6x36 G.H5 L 353 G.H5.25
Polar ICL3 T 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 233 - G.H5 D 341 G.H5.13
Polar TM3 A 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 141 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 141 34x55 G.HN E 28 G.HN.52
Hydrophobic TM6 A 242 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 133 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 C 351 G.H5.23
Polar H8 K 313 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 313 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 313 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 132 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 R 317 8x52 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 R 317 8x52 G.h4s6 T 316 G.h4s6.10
Ionic H8 R 317 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 R 317 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 R 317 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 R 317 8x52 G.h4s6 D 315 G.h4s6.09
Polar ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 137 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals H8 C 312 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 N 230 5x72 G.H5 T 340 G.H5.12
Hydrophobic ICL3 L 232 - G.S6 Y 320 G.S6.02
Hydrophobic TM7 A 311 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 A 311 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 T 226 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 226 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 241 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 249 6x40 G.H5 L 353 G.H5.25