GPCRdb

Refined structure (8JEF) of G_i1 - HCA₃ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2025-03-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 204 from structure (57.6%), 150 from model (42.4%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	AF2	AF2
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	AF2
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	Structure
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	AF2
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	AF2
G.s4h3	233	V	G.s4h3.07	Structure	AF2
G.s4h3	234	L	G.s4h3.08	AF2	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	AF2	AF2
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	Structure
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	AF2
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	Structure
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	AF2
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	AF2
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	AF2	AF2

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (88.8%), 36 from model (11.2%)
Residue sidechains - 235 from structure (73.4%), 85 from model (26.6%)

Showing 1 to 320 of 320 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	N	-	AF2	AF2
N-term	3	R	-	AF2	AF2
N-term	4	H	-	AF2	AF2
N-term	5	H	-	AF2	AF2
N-term	6	L	-	AF2	AF2
N-term	7	Q	-	AF2	AF2
N-term	8	D	-	AF2	AF2
N-term	9	H	-	AF2	AF2
N-term	10	F	-	AF2	AF2
N-term	11	L	-	AF2	AF2
N-term	12	E	-	AF2	AF2
N-term	13	I	-	AF2	AF2
N-term	14	D	-	AF2	AF2
N-term	15	K	-	AF2	AF2
N-term	16	K	-	AF2	AF2
N-term	17	N	-	Structure	AF2
N-term	18	C	-	Structure	Structure
N-term	19	C	-	Structure	Structure
N-term	20	V	-	Structure	AF2
N-term	21	F	-	Structure	Structure
N-term	22	R	-	Structure	Structure
TM1	23	D	1.28x28	Structure	Structure
TM1	24	D	1.29x29	Structure	Structure
TM1	25	F	1.30x30	Structure	Structure
TM1	26	I	1.31x31	Structure	AF2
TM1	27	A	1.32x32	Structure	Structure
TM1	28	K	1.33x33	Structure	AF2
TM1	29	V	1.34x34	Structure	Structure
TM1	30	L	1.35x35	Structure	Structure
TM1	31	P	1.36x36	Structure	Structure
TM1	32	P	1.37x37	Structure	Structure
TM1	33	V	1.38x38	Structure	AF2
TM1	34	L	1.39x39	Structure	Structure
TM1	35	G	1.40x40	Structure	Structure
TM1	36	L	1.41x41	Structure	AF2
TM1	37	E	1.42x42	Structure	Structure
TM1	38	F	1.43x43	Structure	AF2
TM1	39	I	1.44x44	Structure	AF2
TM1	40	F	1.45x45	Structure	AF2
TM1	41	G	1.46x46	Structure	Structure
TM1	42	L	1.47x47	Structure	Structure
TM1	43	L	1.48x48	Structure	AF2
TM1	44	G	1.49x49	Structure	Structure
TM1	45	N	1.50x50	Structure	Structure
TM1	46	G	1.51x51	Structure	Structure
TM1	47	L	1.52x52	Structure	AF2
TM1	48	A	1.53x53	Structure	Structure
TM1	49	L	1.54x54	Structure	Structure
TM1	50	W	1.55x55	Structure	AF2
TM1	51	I	1.56x56	Structure	Structure
TM1	52	F	1.57x57	Structure	Structure
TM1	53	C	1.58x58	Structure	Structure
TM1	54	F	1.59x59	Structure	AF2
TM1	55	H	1.60x60	Structure	AF2
ICL1	56	L	-	Structure	Structure
ICL1	57	K	-	Structure	AF2
ICL1	58	S	-	Structure	Structure
ICL1	59	W	-	Structure	Structure
TM2	60	K	2.37x37	Structure	Structure
TM2	61	S	2.38x38	Structure	Structure
TM2	62	S	2.39x39	Structure	Structure
TM2	63	R	2.40x40	Structure	Structure
TM2	64	I	2.41x41	Structure	Structure
TM2	65	F	2.42x42	Structure	Structure
TM2	66	L	2.43x43	Structure	Structure
TM2	67	F	2.44x44	Structure	Structure
TM2	68	N	2.45x45	Structure	Structure
TM2	69	L	2.46x46	Structure	Structure
TM2	70	A	2.47x47	Structure	Structure
TM2	71	V	2.48x48	Structure	Structure
TM2	72	A	2.49x49	Structure	Structure
TM2	73	D	2.50x50	Structure	Structure
TM2	74	F	2.51x51	Structure	AF2
TM2	75	L	2.52x52	Structure	Structure
TM2	76	L	2.53x53	Structure	Structure
TM2	77	I	2.54x54	Structure	Structure
TM2	78	I	2.55x55	Structure	Structure
TM2	79	C	2.56x56	Structure	Structure
TM2	80	L	2.57x57	Structure	Structure
TM2	81	P	2.58x58	Structure	Structure
TM2	82	F	2.59x59	Structure	Structure
TM2	83	V	2.60x60	Structure	AF2
TM2	84	M	2.61x61	Structure	AF2
TM2	85	D	2.62x62	Structure	AF2
TM2	86	Y	2.63x63	Structure	Structure
TM2	87	Y	2.64x64	Structure	AF2
TM2	88	V	2.65x65	Structure	AF2
TM2	89	R	2.66x66	Structure	AF2
ECL1	90	R	-	Structure	AF2
ECL1	91	S	-	Structure	Structure
ECL1	92	D	23.49x49	Structure	AF2
ECL1	93	W	23.50x50	Structure	Structure
ECL1	94	K	23.51x51	Structure	AF2
ECL1	95	F	23.52x52	Structure	Structure
TM3	96	G	3.21x21	Structure	Structure
TM3	97	D	3.22x22	Structure	Structure
TM3	98	I	3.23x23	Structure	Structure
TM3	99	P	3.24x24	Structure	Structure
TM3	100	C	3.25x25	Structure	Structure
TM3	101	R	3.26x26	Structure	Structure
TM3	102	L	3.27x27	Structure	Structure
TM3	103	V	3.28x28	Structure	Structure
TM3	104	L	3.29x29	Structure	Structure
TM3	105	F	3.30x30	Structure	Structure
TM3	106	M	3.31x31	Structure	Structure
TM3	107	F	3.32x32	Structure	Structure
TM3	108	A	3.33x33	Structure	Structure
TM3	109	M	3.34x34	Structure	Structure
TM3	110	N	3.35x35	Structure	AF2
TM3	111	R	3.36x36	Structure	Structure
TM3	112	Q	3.37x37	Structure	Structure
TM3	113	G	3.38x38	Structure	Structure
TM3	114	S	3.39x39	Structure	Structure
TM3	115	I	3.40x40	Structure	Structure
TM3	116	I	3.41x41	Structure	Structure
TM3	117	F	3.42x42	Structure	Structure
TM3	118	L	3.43x43	Structure	Structure
TM3	119	T	3.44x44	Structure	Structure
TM3	120	V	3.45x45	Structure	Structure
TM3	121	V	3.46x46	Structure	Structure
TM3	122	A	3.47x47	Structure	Structure
TM3	123	V	3.48x48	Structure	Structure
TM3	124	D	3.49x49	Structure	Structure
TM3	125	R	3.50x50	Structure	Structure
TM3	126	Y	3.51x51	Structure	Structure
TM3	127	F	3.52x52	Structure	Structure
TM3	128	R	3.53x53	Structure	Structure
TM3	129	V	3.54x54	Structure	Structure
TM3	130	V	3.55x55	Structure	Structure
TM3	131	H	3.56x56	Structure	Structure
ICL2	132	P	34.50x50	Structure	Structure
ICL2	133	H	34.51x51	Structure	Structure
ICL2	134	H	34.52x52	Structure	Structure
ICL2	135	A	34.53x53	Structure	Structure
ICL2	136	L	34.54x54	Structure	Structure
ICL2	137	N	34.55x55	Structure	Structure
ICL2	138	K	34.56x56	Structure	Structure
ICL2	139	I	34.57x57	Structure	Structure
TM4	140	S	4.38x38	Structure	Structure
TM4	141	N	4.39x39	Structure	Structure
TM4	142	W	4.40x40	Structure	Structure
TM4	143	T	4.41x41	Structure	Structure
TM4	144	A	4.42x42	Structure	Structure
TM4	145	A	4.43x43	Structure	Structure
TM4	146	I	4.44x44	Structure	Structure
TM4	147	I	4.45x45	Structure	Structure
TM4	148	S	4.46x46	Structure	Structure
TM4	149	C	4.47x47	Structure	Structure
TM4	150	L	4.48x48	Structure	Structure
TM4	151	L	4.49x49	Structure	Structure
TM4	152	W	4.50x50	Structure	Structure
TM4	153	G	4.51x51	Structure	Structure
TM4	154	I	4.52x52	Structure	Structure
TM4	155	T	4.53x53	Structure	Structure
TM4	156	V	4.54x54	Structure	Structure
TM4	157	G	4.55x55	Structure	Structure
TM4	158	L	4.56x56	Structure	Structure
TM4	159	T	4.57x57	Structure	Structure
TM4	160	V	4.58x58	Structure	Structure
TM4	161	H	4.59x59	Structure	Structure
TM4	162	L	4.60x60	Structure	Structure
TM4	163	L	4.61x61	Structure	Structure
TM4	164	K	4.62x62	Structure	AF2
TM4	165	K	4.63x63	Structure	AF2
TM4	166	K	4.64x64	Structure	AF2
ECL2	167	L	-	Structure	AF2
ECL2	168	L	-	Structure	Structure
ECL2	169	I	-	Structure	Structure
ECL2	170	Q	-	Structure	AF2
ECL2	171	N	-	Structure	AF2
ECL2	172	G	-	Structure	Structure
ECL2	173	T	-	Structure	AF2
ECL2	174	A	-	Structure	Structure
ECL2	175	N	-	Structure	Structure
ECL2	176	V	-	Structure	Structure
ECL2	177	C	45.50x50	Structure	Structure
ECL2	178	I	45.51x51	Structure	AF2
ECL2	179	S	45.52x52	Structure	Structure
ECL2	180	F	-	Structure	Structure
ECL2	181	S	-	Structure	Structure
ECL2	182	I	-	Structure	Structure
ECL2	183	C	-	Structure	Structure
ECL2	184	H	-	Structure	AF2
ECL2	185	T	-	Structure	Structure
ECL2	186	F	-	Structure	Structure
TM5	187	R	5.37x38	Structure	AF2
TM5	188	W	5.38x39	Structure	AF2
TM5	189	H	5.39x40	Structure	Structure
TM5	190	E	5.40x41	Structure	AF2
TM5	191	A	5.41x42	Structure	Structure
TM5	192	M	5.42x43	Structure	AF2
TM5	193	F	5.43x44	Structure	Structure
TM5	194	L	5.44x45	Structure	Structure
TM5	195	L	5.45x46	Structure	Structure
TM5	196	E	5.46x461	Structure	Structure
TM5	197	F	5.47x47	Structure	Structure
TM5	198	F	5.48x48	Structure	Structure
TM5	199	L	5.49x49	Structure	AF2
TM5	200	P	5.50x50	Structure	Structure
TM5	201	L	5.51x51	Structure	Structure
TM5	202	G	5.52x52	Structure	Structure
TM5	203	I	5.53x53	Structure	Structure
TM5	204	I	5.54x54	Structure	Structure
TM5	205	L	5.55x55	Structure	Structure
TM5	206	F	5.56x56	Structure	Structure
TM5	207	C	5.57x57	Structure	Structure
TM5	208	S	5.58x58	Structure	Structure
TM5	209	A	5.59x59	Structure	Structure
TM5	210	R	5.60x60	Structure	Structure
TM5	211	I	5.61x61	Structure	Structure
TM5	212	I	5.62x62	Structure	Structure
TM5	213	W	5.63x63	Structure	Structure
TM5	214	S	5.64x64	Structure	Structure
TM5	215	L	5.65x65	Structure	Structure
TM5	216	R	5.66x66	Structure	Structure
TM5	217	Q	5.67x67	Structure	Structure
TM5	218	R	5.68x68	Structure	Structure
ICL3	219	Q	-	Structure	Structure
ICL3	220	M	-	Structure	Structure
ICL3	221	D	-	Structure	Structure
ICL3	222	R	-	Structure	Structure
ICL3	223	H	-	Structure	Structure
ICL3	224	A	-	Structure	Structure
TM6	225	K	6.29x29	Structure	Structure
TM6	226	I	6.30x30	Structure	Structure
TM6	227	K	6.31x31	Structure	Structure
TM6	228	R	6.32x32	Structure	Structure
TM6	229	A	6.33x33	Structure	Structure
TM6	230	I	6.34x34	Structure	Structure
TM6	231	T	6.35x35	Structure	Structure
TM6	232	F	6.36x36	Structure	Structure
TM6	233	I	6.37x37	Structure	Structure
TM6	234	M	6.38x38	Structure	Structure
TM6	235	V	6.39x39	Structure	Structure
TM6	236	V	6.40x40	Structure	Structure
TM6	237	A	6.41x41	Structure	Structure
TM6	238	I	6.42x42	Structure	Structure
TM6	239	V	6.43x43	Structure	Structure
TM6	240	F	6.44x44	Structure	Structure
TM6	241	V	6.45x45	Structure	Structure
TM6	242	I	6.46x46	Structure	Structure
TM6	243	C	6.47x47	Structure	Structure
TM6	244	F	6.48x48	Structure	Structure
TM6	245	L	6.49x49	Structure	Structure
TM6	246	P	6.50x50	Structure	Structure
TM6	247	S	6.51x51	Structure	Structure
TM6	248	V	6.52x52	Structure	Structure
TM6	249	V	6.53x53	Structure	Structure
TM6	250	V	6.54x54	Structure	Structure
TM6	251	R	6.55x55	Structure	Structure
TM6	252	I	6.56x56	Structure	Structure
TM6	253	H	6.57x57	Structure	Structure
TM6	254	I	6.58x58	Structure	Structure
TM6	255	F	6.59x59	Structure	Structure
TM6	256	W	6.60x60	Structure	AF2
TM6	257	L	6.61x61	Structure	Structure
TM6	258	L	6.62x62	Structure	Structure
TM6	259	H	6.63x63	Structure	Structure
TM6	260	T	6.64x64	Structure	AF2
TM6	261	S	6.65x65	Structure	Structure
ECL3	262	G	-	Structure	Structure
ECL3	263	T	-	Structure	AF2
ECL3	264	Q	-	Structure	AF2
ECL3	265	N	-	Structure	AF2
ECL3	266	C	-	Structure	Structure
ECL3	267	E	-	Structure	AF2
TM7	268	V	7.27x26	Structure	AF2
TM7	269	Y	7.28x27	Structure	Structure
TM7	270	R	7.29x28	Structure	Structure
TM7	271	S	7.30x29	Structure	Structure
TM7	272	V	7.31x30	Structure	Structure
TM7	273	D	7.32x31	Structure	Structure
TM7	274	L	7.33x32	Structure	Structure
TM7	275	A	7.34x33	Structure	Structure
TM7	276	F	7.35x34	Structure	Structure
TM7	277	F	7.36x35	Structure	AF2
TM7	278	I	7.37x36	Structure	Structure
TM7	279	T	7.38x37	Structure	Structure
TM7	280	L	7.39x38	Structure	Structure
TM7	281	S	7.40x39	Structure	Structure
TM7	282	F	7.41x40	Structure	Structure
TM7	283	T	7.42x41	Structure	Structure
TM7	284	Y	7.43x42	Structure	Structure
TM7	285	M	7.44x43	Structure	Structure
TM7	286	N	7.45x45	Structure	Structure
TM7	287	S	7.46x46	Structure	Structure
TM7	288	M	7.47x47	Structure	Structure
TM7	289	L	7.48x48	Structure	Structure
TM7	290	D	7.49x49	Structure	Structure
TM7	291	P	7.50x50	Structure	Structure
TM7	292	V	7.51x51	Structure	Structure
TM7	293	V	7.52x52	Structure	AF2
TM7	294	Y	7.53x53	Structure	Structure
TM7	295	Y	7.54x54	Structure	Structure
TM7	296	F	7.55x55	Structure	Structure
TM7	297	S	7.56x56	Structure	Structure
H8	298	S	8.47x47	Structure	Structure
H8	299	P	8.48x48	Structure	Structure
H8	300	S	8.49x49	Structure	Structure
H8	301	F	8.50x50	AF2	AF2
H8	302	P	8.51x51	AF2	AF2
H8	303	N	8.52x52	AF2	AF2
H8	304	F	8.53x53	AF2	AF2
H8	305	F	8.54x54	AF2	AF2
H8	306	S	8.55x55	AF2	AF2
H8	307	T	8.56x56	AF2	AF2
H8	308	L	8.57x57	AF2	AF2
H8	309	I	8.58x58	AF2	AF2
H8	310	N	8.59x59	AF2	AF2
C-term	311	R	-	AF2	AF2
C-term	312	C	-	AF2	AF2
C-term	313	L	-	AF2	AF2
C-term	314	Q	-	AF2	AF2
C-term	315	R	-	AF2	AF2
C-term	316	K	-	AF2	AF2
C-term	317	I	-	AF2	AF2
C-term	318	T	-	AF2	AF2
C-term	319	G	-	AF2	AF2
C-term	320	E	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	TM6	K	225	6x29	G.H5	F	354	G.H5.26
Aromatic	TM6	R	228	6x32	G.H5	F	354	G.H5.26
Hydrophobic	TM6	A	229	6x33	G.H5	L	353	G.H5.25
Hydrophobic	H8	P	299	8x48	G.H5	L	353	G.H5.25
Hydrophobic	TM6	K	225	6x29	G.H5	F	354	G.H5.26
Hydrophobic	TM3	R	128	3x53	G.H5	N	347	G.H5.19
Hydrophobic	ICL2	H	133	34x51	G.H5	T	340	G.H5.12
Hydrophobic	ICL3	M	220	-	G.H5	K	345	G.H5.17
Hydrophobic	TM2	R	63	2x40	G.H5	G	352	G.H5.24
Hydrophobic	TM3	R	128	3x53	G.H5	C	351	G.H5.23
Hydrophobic	ICL3	A	224	-	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	P	132	34x50	G.H5	T	340	G.H5.12
Hydrophobic	TM6	K	225	6x29	G.H5	K	349	G.H5.21
Hydrophobic	TM6	K	225	6x29	G.H5	K	345	G.H5.17
Hydrophobic	ICL2	H	133	34x51	G.H5	F	336	G.H5.08
Hydrophobic	TM6	I	233	6x37	G.H5	L	353	G.H5.25
Hydrophobic	TM2	S	62	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM5	R	218	5x68	G.H5	I	344	G.H5.16
Hydrophobic	ICL3	H	223	-	G.h4s6	T	316	G.h4s6.10
Hydrophobic	ICL2	P	132	34x50	G.H5	I	344	G.H5.16
Hydrophobic	TM5	R	218	5x68	G.H5	T	340	G.H5.12
Hydrophobic	ICL3	H	223	-	G.h4s6	D	315	G.h4s6.09
Hydrophobic	TM6	K	225	6x29	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	H	133	34x51	G.S3	L	194	G.S3.01
Hydrophobic	TM3	R	125	3x50	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	K	138	34x56	G.hns1	R	32	G.hns1.03
Hydrophobic	TM5	L	215	5x65	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	P	132	34x50	G.H5	I	343	G.H5.15
Hydrophobic	TM2	K	60	2x37	G.H5	D	350	G.H5.22
Hydrophobic	H8	P	299	8x48	G.H5	F	354	G.H5.26
Hydrophobic	TM5	L	215	5x65	G.H5	L	348	G.H5.20
Hydrophobic	H8	S	300	8x49	G.H5	G	352	G.H5.24
Hydrophobic	TM5	R	218	5x68	G.H5	D	341	G.H5.13
Hydrophobic	ICL2	H	133	34x51	G.H5	I	343	G.H5.15
Hydrophobic	ICL3	M	220	-	G.H5	I	344	G.H5.16
Hydrophobic	TM6	R	228	6x32	G.H5	F	354	G.H5.26
Hydrophobic	TM3	V	129	3x54	G.H5	L	348	G.H5.20
Hydrophobic	H8	S	298	8x47	G.H5	G	352	G.H5.24
Ionic	ICL3	H	223	-	G.h4s6	E	318	G.h4s6.12
Ionic	TM2	K	60	2x37	G.H5	D	350	G.H5.22
Ionic	TM5	R	218	5x68	G.H5	D	341	G.H5.13
Polar	TM3	R	128	3x53	G.H5	N	347	G.H5.19
Polar	ICL2	H	133	34x51	G.H5	T	340	G.H5.12
Polar	TM2	R	63	2x40	G.H5	C	351	G.H5.23
Polar	TM2	R	63	2x40	G.H5	G	352	G.H5.24
Polar	ICL2	P	132	34x50	G.H5	N	347	G.H5.19
Polar	TM2	S	62	2x39	G.H5	C	351	G.H5.23
Polar	ICL3	H	223	-	G.h4s6	T	316	G.h4s6.10
Polar	TM6	R	228	6x32	G.H5	L	353	G.H5.25
Polar	ICL3	H	223	-	G.h4s6	D	315	G.h4s6.09
Polar	H8	S	300	8x49	G.H5	G	352	G.H5.24
Polar	TM5	R	218	5x68	G.H5	D	341	G.H5.13
Polar	H8	S	298	8x47	G.H5	G	352	G.H5.24
Van-der-waals	TM6	A	229	6x33	G.H5	L	353	G.H5.25
Van-der-waals	H8	P	299	8x48	G.H5	L	353	G.H5.25
Van-der-waals	TM6	K	225	6x29	G.H5	F	354	G.H5.26
Van-der-waals	TM3	R	128	3x53	G.H5	N	347	G.H5.19
Van-der-waals	ICL2	H	133	34x51	G.H5	T	340	G.H5.12
Van-der-waals	ICL3	M	220	-	G.H5	K	345	G.H5.17
Van-der-waals	TM2	R	63	2x40	G.H5	G	352	G.H5.24
Van-der-waals	TM3	R	128	3x53	G.H5	C	351	G.H5.23
Van-der-waals	ICL2	P	132	34x50	G.H5	N	347	G.H5.19
Van-der-waals	TM6	K	225	6x29	G.H5	K	349	G.H5.21
Van-der-waals	TM2	S	62	2x39	G.H5	C	351	G.H5.23
Van-der-waals	ICL2	P	132	34x50	G.H5	I	344	G.H5.16
Van-der-waals	TM5	R	218	5x68	G.H5	T	340	G.H5.12
Van-der-waals	ICL3	H	223	-	G.h4s6	D	315	G.h4s6.09
Van-der-waals	TM6	K	225	6x29	G.H5	L	348	G.H5.20
Van-der-waals	TM3	R	125	3x50	G.H5	L	353	G.H5.25
Van-der-waals	ICL2	P	132	34x50	G.H5	I	343	G.H5.15
Van-der-waals	H8	P	299	8x48	G.H5	F	354	G.H5.26
Van-der-waals	TM5	R	218	5x68	G.H5	D	341	G.H5.13
Van-der-waals	ICL2	H	133	34x51	G.H5	I	343	G.H5.15
Van-der-waals	TM6	R	228	6x32	G.H5	F	354	G.H5.26
Van-der-waals	TM3	V	129	3x54	G.H5	L	348	G.H5.20
Van-der-waals	H8	S	298	8x47	G.H5	G	352	G.H5.24

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Main reference

Refined structure (8JEF) of Gi1 - HCA3 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8JEF) of G_i1 - HCA₃ receptor

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