Refined structure (8XBE) of Gi1 - GPR34

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 204 from structure (57.6%), 150 from model (42.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (83.5%), 59 from model (16.5%)
Residue sidechains - 297 from structure (83.2%), 60 from model (16.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 R - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 H - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 I - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 M - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 W - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 Y - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 H - AF2 AF2
N-term 22 R - AF2 AF2
N-term 23 M - AF2 AF2
N-term 24 R - AF2 AF2
N-term 25 F - AF2 AF2
N-term 26 I - AF2 AF2
N-term 27 T - AF2 AF2
N-term 28 N - AF2 AF2
N-term 29 H - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 D - AF2 AF2
N-term 32 Q - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 Q - AF2 AF2
N-term 36 N - AF2 AF2
N-term 37 F - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 A - AF2 AF2
N-term 40 T - AF2 AF2
N-term 41 P - AF2 AF2
N-term 42 N - AF2 AF2
N-term 43 V - AF2 AF2
N-term 44 T - AF2 AF2
N-term 45 T - Structure Structure
N-term 46 C - Structure Structure
N-term 47 P - Structure Structure
N-term 48 M - Structure Structure
N-term 49 D - Structure Structure
N-term 50 E - Structure Structure
N-term 51 K - Structure Structure
TM1 52 L 1.30x30 Structure Structure
TM1 53 L 1.31x31 Structure Structure
TM1 54 S 1.32x32 Structure Structure
TM1 55 T 1.33x33 Structure Structure
TM1 56 V 1.34x34 Structure Structure
TM1 57 L 1.35x35 Structure Structure
TM1 58 T 1.36x36 Structure Structure
TM1 59 T 1.37x37 Structure Structure
TM1 60 S 1.38x38 Structure Structure
TM1 61 Y 1.39x39 Structure Structure
TM1 62 S 1.40x40 Structure Structure
TM1 63 V 1.41x41 Structure Structure
TM1 64 I 1.42x42 Structure Structure
TM1 65 F 1.43x43 Structure Structure
TM1 66 I 1.44x44 Structure Structure
TM1 67 V 1.45x45 Structure Structure
TM1 68 G 1.46x46 Structure Structure
TM1 69 L 1.47x47 Structure Structure
TM1 70 V 1.48x48 Structure Structure
TM1 71 G 1.49x49 Structure Structure
TM1 72 N 1.50x50 Structure Structure
TM1 73 I 1.51x51 Structure Structure
TM1 74 I 1.52x52 Structure Structure
TM1 75 A 1.53x53 Structure Structure
TM1 76 L 1.54x54 Structure Structure
TM1 77 Y 1.55x55 Structure Structure
TM1 78 V 1.56x56 Structure Structure
TM1 79 F 1.57x57 Structure Structure
TM1 80 L 1.58x58 Structure Structure
TM1 81 G 1.59x59 Structure Structure
TM1 82 I 1.60x60 Structure Structure
TM1 83 H 1.61x61 Structure Structure
ICL1 84 R - Structure Structure
ICL1 85 K - Structure Structure
ICL1 86 R - Structure Structure
TM2 87 N 2.37x37 Structure Structure
TM2 88 S 2.38x38 Structure Structure
TM2 89 I 2.39x39 Structure Structure
TM2 90 Q 2.40x40 Structure Structure
TM2 91 I 2.41x41 Structure Structure
TM2 92 Y 2.42x42 Structure Structure
TM2 93 L 2.43x43 Structure Structure
TM2 94 L 2.44x44 Structure Structure
TM2 95 N 2.45x45 Structure Structure
TM2 96 V 2.46x46 Structure Structure
TM2 97 A 2.47x47 Structure Structure
TM2 98 I 2.48x48 Structure Structure
TM2 99 A 2.49x49 Structure Structure
TM2 100 D 2.50x50 Structure Structure
TM2 101 L 2.51x51 Structure Structure
TM2 102 L 2.52x52 Structure Structure
TM2 103 L 2.53x53 Structure Structure
TM2 104 I 2.54x54 Structure Structure
TM2 105 F 2.55x55 Structure Structure
TM2 106 C 2.56x56 Structure Structure
TM2 107 L 2.57x57 Structure Structure
TM2 108 P 2.58x58 Structure Structure
TM2 109 F 2.59x59 Structure Structure
TM2 110 R 2.60x60 Structure Structure
TM2 111 I 2.61x61 Structure Structure
TM2 112 M 2.62x62 Structure Structure
TM2 113 Y 2.63x63 Structure Structure
TM2 114 H 2.64x64 Structure Structure
TM2 115 I 2.65x65 Structure Structure
TM2 116 N 2.66x66 Structure Structure
TM2 117 Q 2.67x67 Structure Structure
ECL1 118 N - Structure Structure
ECL1 119 K 23.49x49 Structure Structure
ECL1 120 W 23.50x50 Structure Structure
ECL1 121 T 23.51x51 Structure Structure
ECL1 122 L 23.52x52 Structure Structure
TM3 123 G 3.21x21 Structure Structure
TM3 124 V 3.22x22 Structure Structure
TM3 125 I 3.23x23 Structure Structure
TM3 126 L 3.24x24 Structure Structure
TM3 127 C 3.25x25 Structure Structure
TM3 128 K 3.26x26 Structure Structure
TM3 129 V 3.27x27 Structure Structure
TM3 130 V 3.28x28 Structure Structure
TM3 131 G 3.29x29 Structure Structure
TM3 132 T 3.30x30 Structure Structure
TM3 133 L 3.31x31 Structure Structure
TM3 134 F 3.32x32 Structure Structure
TM3 135 Y 3.33x33 Structure Structure
TM3 136 M 3.34x34 Structure Structure
TM3 137 N 3.35x35 Structure Structure
TM3 138 M 3.36x36 Structure Structure
TM3 139 Y 3.37x37 Structure Structure
TM3 140 I 3.38x38 Structure Structure
TM3 141 S 3.39x39 Structure Structure
TM3 142 I 3.40x40 Structure Structure
TM3 143 I 3.41x41 Structure Structure
TM3 144 L 3.42x42 Structure Structure
TM3 145 L 3.43x43 Structure Structure
TM3 146 G 3.44x44 Structure Structure
TM3 147 F 3.45x45 Structure Structure
TM3 148 I 3.46x46 Structure Structure
TM3 149 S 3.47x47 Structure Structure
TM3 150 L 3.48x48 Structure Structure
TM3 151 D 3.49x49 Structure Structure
TM3 152 R 3.50x50 Structure Structure
TM3 153 Y 3.51x51 Structure Structure
TM3 154 I 3.52x52 Structure Structure
TM3 155 K 3.53x53 Structure Structure
TM3 156 I 3.54x54 Structure Structure
TM3 157 N 3.55x55 Structure Structure
TM3 158 R 3.56x56 Structure Structure
TM3 159 S 3.57x57 Structure Structure
ICL2 160 I - Structure Structure
ICL2 161 Q - Structure Structure
ICL2 162 Q - Structure Structure
ICL2 163 R - Structure Structure
ICL2 164 K - Structure AF2
ICL2 165 A - Structure Structure
ICL2 166 I - Structure Structure
ICL2 167 T - Structure Structure
ICL2 168 T - Structure Structure
TM4 169 K 4.40x40 Structure Structure
TM4 170 Q 4.41x41 Structure Structure
TM4 171 S 4.42x42 Structure Structure
TM4 172 I 4.43x43 Structure Structure
TM4 173 Y 4.44x44 Structure Structure
TM4 174 V 4.45x45 Structure Structure
TM4 175 C 4.46x46 Structure Structure
TM4 176 C 4.47x47 Structure Structure
TM4 177 I 4.48x48 Structure Structure
TM4 178 V 4.49x49 Structure Structure
TM4 179 W 4.50x50 Structure Structure
TM4 180 M 4.51x51 Structure Structure
TM4 181 L 4.52x52 Structure Structure
TM4 182 A 4.53x53 Structure Structure
TM4 183 L 4.54x54 Structure Structure
TM4 184 G 4.55x55 Structure Structure
TM4 185 G 4.56x56 Structure Structure
TM4 186 F 4.57x57 Structure Structure
TM4 187 L 4.58x58 Structure Structure
TM4 188 T 4.59x59 Structure Structure
TM4 189 M 4.60x60 Structure Structure
TM4 190 I 4.61x61 Structure Structure
TM4 191 I 4.62x62 Structure Structure
TM4 192 L 4.63x63 Structure Structure
TM4 193 T 4.64x64 Structure Structure
TM4 194 L 4.65x65 Structure Structure
TM4 195 K 4.66x66 Structure Structure
TM4 196 K 4.67x67 Structure Structure
TM4 197 G 4.68x68 Structure Structure
ECL2 198 G - Structure Structure
ECL2 199 H - Structure Structure
ECL2 200 N - Structure Structure
ECL2 201 S - Structure Structure
ECL2 202 T - Structure Structure
ECL2 203 M - Structure Structure
ECL2 204 C 45.50x50 Structure Structure
ECL2 205 F 45.51x51 Structure Structure
ECL2 206 H 45.52x52 Structure Structure
ECL2 207 Y - Structure Structure
ECL2 208 R - Structure Structure
ECL2 209 D - Structure Structure
ECL2 210 K - Structure Structure
ECL2 211 H - Structure Structure
ECL2 212 N - Structure Structure
ECL2 213 A - Structure Structure
TM5 214 K 5.34x34 Structure Structure
TM5 215 G 5.35x35 Structure Structure
TM5 216 E 5.36x36 Structure Structure
TM5 217 A 5.37x37 Structure Structure
TM5 218 I 5.38x38 Structure Structure
TM5 219 F 5.39x39 Structure Structure
TM5 220 N 5.40x40 Structure Structure
TM5 221 F 5.41x41 Structure Structure
TM5 222 I 5.42x42 Structure Structure
TM5 223 L 5.43x43 Structure Structure
TM5 224 V 5.44x44 Structure Structure
TM5 225 V 5.45x45 Structure Structure
TM5 226 M 5.46x46 Structure Structure
TM5 227 F 5.47x47 Structure Structure
TM5 228 W 5.48x48 Structure Structure
TM5 229 L 5.49x49 Structure Structure
TM5 230 I 5.50x50 Structure Structure
TM5 231 F 5.51x51 Structure Structure
TM5 232 L 5.52x52 Structure Structure
TM5 233 L 5.53x53 Structure Structure
TM5 234 I 5.54x54 Structure Structure
TM5 235 I 5.55x55 Structure Structure
TM5 236 L 5.56x56 Structure Structure
TM5 237 S 5.57x57 Structure Structure
TM5 238 Y 5.58x58 Structure Structure
TM5 239 I 5.59x59 Structure Structure
TM5 240 K 5.60x60 Structure Structure
TM5 241 I 5.61x61 Structure Structure
TM5 242 G 5.62x62 Structure Structure
TM5 243 K 5.63x63 Structure Structure
TM5 244 N 5.64x64 Structure Structure
TM5 245 L 5.65x65 Structure Structure
TM5 246 L 5.66x66 Structure Structure
TM5 247 R 5.67x67 Structure Structure
TM5 248 I 5.68x68 Structure Structure
TM5 249 S 5.69x69 Structure Structure
TM5 250 K 5.70x70 Structure Structure
ICL3 251 R - Structure Structure
ICL3 252 R - Structure Structure
ICL3 253 S - Structure Structure
ICL3 254 K - Structure Structure
ICL3 255 F - Structure Structure
ICL3 256 P - Structure Structure
ICL3 257 N - Structure Structure
TM6 258 S 6.27x28 Structure Structure
TM6 259 G 6.28x29 Structure Structure
TM6 260 K 6.29x30 Structure Structure
TM6 261 Y 6.30x31 Structure Structure
TM6 262 A 6.31x32 Structure Structure
TM6 263 T 6.32x33 Structure Structure
TM6 264 T 6.33x34 Structure Structure
TM6 265 A 6.34x35 Structure Structure
TM6 266 R 6.35x36 Structure Structure
TM6 267 N 6.36x37 Structure Structure
TM6 268 S 6.37x38 Structure Structure
TM6 269 F 6.38x39 Structure Structure
TM6 270 I 6.39x40 Structure Structure
TM6 271 V 6.40x41 Structure Structure
TM6 272 L 6.41x42 Structure Structure
TM6 273 I 6.42x43 Structure Structure
TM6 274 I 6.43x44 Structure Structure
TM6 275 F 6.44x45 Structure Structure
TM6 276 T 6.45x46 Structure Structure
TM6 277 I 6.46x461 Structure Structure
TM6 278 C 6.47x47 Structure Structure
TM6 279 F 6.48x48 Structure Structure
TM6 280 V 6.49x49 Structure Structure
TM6 281 P 6.50x50 Structure Structure
TM6 282 Y 6.51x51 Structure Structure
TM6 283 H 6.52x52 Structure Structure
TM6 284 A 6.53x53 Structure Structure
TM6 285 F 6.54x54 Structure Structure
TM6 286 R 6.55x55 Structure Structure
TM6 287 F 6.56x56 Structure Structure
TM6 288 I 6.57x57 Structure Structure
TM6 289 Y 6.58x58 Structure Structure
TM6 290 I 6.59x59 Structure Structure
TM6 291 S 6.60x60 Structure Structure
TM6 292 S 6.61x61 Structure Structure
ECL3 293 Q - Structure Structure
ECL3 294 L - Structure Structure
ECL3 295 N - Structure Structure
ECL3 296 V - Structure Structure
ECL3 297 S - Structure Structure
TM7 298 S 7.24x23 Structure Structure
TM7 299 C 7.25x24 Structure Structure
TM7 300 Y 7.26x25 Structure Structure
TM7 301 W 7.27x26 Structure Structure
TM7 302 K 7.28x27 Structure Structure
TM7 303 E 7.29x28 Structure Structure
TM7 304 I 7.30x29 Structure Structure
TM7 305 V 7.31x30 Structure Structure
TM7 306 H 7.32x31 Structure Structure
TM7 307 K 7.33x32 Structure Structure
TM7 308 T 7.34x33 Structure Structure
TM7 309 N 7.35x34 Structure Structure
TM7 310 E 7.36x35 Structure Structure
TM7 311 I 7.37x36 Structure Structure
TM7 312 M 7.38x37 Structure Structure
TM7 313 L 7.39x38 Structure Structure
TM7 314 V 7.40x39 Structure Structure
TM7 315 L 7.41x40 Structure Structure
TM7 316 S 7.42x41 Structure Structure
TM7 317 S 7.43x42 Structure Structure
TM7 318 F 7.44x43 Structure Structure
TM7 319 N 7.45x45 Structure Structure
TM7 320 S 7.46x46 Structure Structure
TM7 321 C 7.47x47 Structure Structure
TM7 322 L 7.48x48 Structure Structure
TM7 323 D 7.49x49 Structure Structure
TM7 324 P 7.50x50 Structure Structure
TM7 325 V 7.51x51 Structure Structure
TM7 326 M 7.52x52 Structure Structure
TM7 327 Y 7.53x53 Structure Structure
TM7 328 F 7.54x54 Structure Structure
TM7 329 L 7.55x55 Structure Structure
TM7 330 M 7.56x56 Structure Structure
H8 331 S 8.47x47 Structure Structure
H8 332 S 8.48x48 Structure Structure
H8 333 N 8.49x49 Structure Structure
H8 334 I 8.50x50 Structure Structure
H8 335 R 8.51x51 Structure Structure
H8 336 K 8.52x52 Structure Structure
H8 337 I 8.53x53 Structure Structure
H8 338 M 8.54x54 Structure Structure
H8 339 C 8.55x55 Structure Structure
H8 340 Q 8.56x56 Structure Structure
H8 341 L 8.57x57 Structure Structure
H8 342 L 8.58x58 Structure Structure
H8 343 F 8.59x59 AF2 AF2
H8 344 R 8.60x60 AF2 AF2
H8 345 R 8.61x61 AF2 AF2
H8 346 F 8.62x62 AF2 AF2
H8 347 Q 8.63x63 AF2 AF2
C-term 348 G - AF2 AF2
C-term 349 E - AF2 AF2
C-term 350 P - AF2 AF2
C-term 351 S - AF2 AF2
C-term 352 R - AF2 AF2
C-term 353 S - AF2 AF2
C-term 354 E - AF2 AF2
C-term 355 S - AF2 AF2
C-term 356 T - AF2 AF2
C-term 357 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 164 - G.HN G 27 G.HN.51
Van-der-waals ICL2 K 164 - G.HN G 27 G.HN.51
Hydrophobic H8 S 331 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 F 354 G.H5.26
Ionic ICL2 K 164 - G.HN E 28 G.HN.52
Polar ICL2 K 164 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 164 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 164 - G.HN E 28 G.HN.52
Polar H8 S 331 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 260 6x30 G.H5 K 345 G.H5.17
Polar TM3 K 155 3x53 G.H5 N 347 G.H5.19
Polar C-term S 357 - G.H3 N 255 G.H3.14
Hydrophobic C-term S 357 - G.H3 N 255 G.H3.14
Van-der-waals C-term S 357 - G.H3 N 255 G.H3.14
Polar ICL3 K 254 - G.S6 Y 320 G.S6.02
Aromatic ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 254 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic TM7 M 330 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 353 G.H5.25
Polar ICL2 K 164 - G.HN R 24 G.HN.48
Van-der-waals ICL2 K 164 - G.HN R 24 G.HN.48
Hydrophobic ICL2 K 164 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Polar TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x30 G.H5 F 354 G.H5.26
Polar TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Polar H8 S 332 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 S 332 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Q 161 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 161 - G.H5 I 343 G.H5.15
Ionic N-term R 2 - G.HN D 20 G.HN.44
Polar N-term R 2 - G.HN D 20 G.HN.44
Hydrophobic ICL2 Q 161 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 161 - G.hns1 R 32 G.hns1.03
Polar ICL3 N 257 - G.S6 Y 320 G.S6.02
Hydrophobic C-term E 354 - G.h4s6 K 312 G.h4s6.03
Van-der-waals C-term E 354 - G.h4s6 K 312 G.h4s6.03
Hydrophobic TM7 M 330 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 M 330 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Ionic TM6 K 260 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 260 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 260 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL3 P 256 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 P 256 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 T 264 6x34 G.H5 L 348 G.H5.20
Polar TM2 N 87 2x37 G.H5 D 350 G.H5.22
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23
Polar ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term T 356 - G.h4s6 R 313 G.h4s6.04
Hydrophobic TM6 T 264 6x34 G.H5 L 353 G.H5.25
Van-der-waals ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic C-term T 356 - G.H3 K 257 G.H3.16
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 271 6x41 G.H5 L 353 G.H5.25
Ionic H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 166 - G.HN E 28 G.HN.52
Van-der-waals ICL2 I 166 - G.HN E 28 G.HN.52
Hydrophobic ICL3 P 256 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 256 - G.S6 Y 320 G.S6.02
Aromatic H8 R 335 8x51 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Hydrophobic ICL3 K 254 - G.H5 A 338 G.H5.10
Ionic ICL3 K 254 - G.H5 D 341 G.H5.13
Polar ICL3 K 254 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 254 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 254 - G.H5 D 341 G.H5.13
Polar N-term R 2 - G.HN S 16 G.HN.40
Van-der-waals N-term R 2 - G.HN S 16 G.HN.40
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 264 6x34 G.H5 F 354 G.H5.26