CXCR4 (cxcr4_human)

FAMILY

Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR4

GENE

CXCR4

ORGANISM

Human (Homo sapiens)

ALT. NAMES

C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
G
I
S
I
Y
T
S
D
10
                   
N
Y
T
E
E
M
G
S
G
D
20
                   
Y
D
S
M
K
E
P
C
F
R
30
TM1              
E
E
N
A
N
F
N
K
I
F
40
                   
L
P
T
I
Y
S
I
I
F
L
50
                   
T
G
I
V
G
N
G
L
V
I
60
            ICL1
L
V
M
G
Y
Q
K
K
L
R
70
TM2              
S
M
T
D
K
Y
R
L
H
L
80
                   
S
V
A
D
L
L
F
V
I
T
90
                   
L
P
F
W
A
V
D
A
V
A
100
ECL1 TM3      
N
W
Y
F
G
N
F
L
C
K
110
                   
A
V
H
V
I
Y
T
V
N
L
120
                   
Y
S
S
V
L
I
L
A
F
I
130
                   
S
L
D
R
Y
L
A
I
V
H
140
ICL2            
A
T
N
S
Q
R
P
R
K
L
150
TM4              
L
A
E
K
V
V
Y
V
G
V
160
                   
W
I
P
A
L
L
L
T
I
P
170
          ECL2  
D
F
I
F
A
N
V
S
E
A
180
                   
D
D
R
Y
I
C
D
R
F
Y
190
    TM5          
P
N
D
L
W
V
V
V
F
Q
200
                   
F
Q
H
I
M
V
G
L
I
L
210
                   
P
G
I
V
I
L
S
C
Y
C
220
                   
I
I
I
S
K
L
S
H
S
K
230
ICL3 TM6      
G
H
Q
K
R
K
A
L
K
T
240
                   
T
V
I
L
I
L
A
F
F
A
250
                   
C
W
L
P
Y
Y
I
G
I
S
260
                   
I
D
S
F
I
L
L
E
I
I
270
ECL3 TM7      
K
Q
G
C
E
F
E
N
T
V
280
                   
H
K
W
I
S
I
T
E
A
L
290
                   
A
F
F
H
C
C
L
N
P
I
300
          H8      
L
Y
A
F
L
G
A
K
F
K
310
                   
T
S
A
Q
H
A
L
T
S
V
320
C-term        
S
R
G
S
S
L
K
I
L
S
330
                   
K
G
K
R
G
G
H
S
S
V
340
                   
S
T
E
S
E
S
S
S
F
H
350
   
S
S

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K K L R ICL1ECL1 N W Y F ECL1ICL2 A T N S Q R P R ICL2ECL2 N V S E A D D R Y I C D R F Y P N ECL2ICL3 K G H Q ICL3ECL3 I I K Q ECL3N-term M E G I S I Y T S D N Y T E E M G S G D Y D S M K E P C F N-termC-term S V S R G S S L K I L S K G K R G G H S S V S T E S E S S S F H S S C-term R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H K L L A E K V V Y V G V W I P A L L L T I P D F I F A D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K A Q H F K T S A L T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V I G T L F I I S Y I T P L F I K 1 L H L S V A D L L F V I T L P F W A V D 2 F A L I L V S S Y L N V T Y I V H V A K 3 E K V V Y V G V W I P A L L L T I P D 4 Y C S L I V I G P L I L G V M I H Q F Q F 5 V I L I L A F F A C W L P Y Y I G I S I 6 I P N L C C H F F A L A E T I S I W K 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1060 mutation data points available.

PHYSIOLOGICAL LIGANDS

CXCL12, CXCL12γ, CXCL12α, CXCL12φ, CXCL12ε, CXCL12δ, CXCL12β

STRUCTURE MODELS

cxcr4_human active,

cxcr4_human inactive

STRUCTURES

Found 6 structure(s) - view all details on the Structures page

PDBs: 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 4RWS