CXCR4 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8K3Z

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

July 17, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

69 interactions (Click to see)

LIGANDS

Stromal cell-derived factor 1 - Agonist

PHYSIOLOGICAL LIGANDS

CXCL12φ, CXCL12δ, CXCL12α, CXCL12, CXCL12γ, CXCL12β, CXCL12ε



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 234 6x30 G.H5 L 348 G.H5.20
Polar TM2 T 73 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 73 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 73 2x39 G.H5 C 351 G.H5.23
Ionic H8 K 308 8x49 G.H5 D 350 G.H5.22
Polar H8 K 308 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 308 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 308 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 244 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 145 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 I 222 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 141 - G.H5 I 344 G.H5.16
Ionic TM4 K 149 4x38 G.HN E 28 G.HN.52
Polar TM4 K 149 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 K 149 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 149 4x38 G.HN E 28 G.HN.52
Polar TM3 A 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 138 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 Q 233 - G.H5 F 354 G.H5.26
Ionic ICL3 K 230 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL2 A 141 - G.H5 N 347 G.H5.19
Hydrophobic TM6 A 237 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 353 G.H5.25
Polar TM2 T 73 2x39 G.H5 D 350 G.H5.22
Polar TM6 T 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 146 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 K 308 8x49 G.H5 K 349 G.H5.21
Polar ICL3 H 232 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 H 232 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 H 232 - G.h4s6 D 315 G.h4s6.09
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 237 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 Q 233 - G.H5 K 345 G.H5.17
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 142 - G.S3 L 194 G.S3.01
Hydrophobic TM3 I 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 234 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 141 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 141 - G.H5 I 343 G.H5.15
Polar ICL3 Q 233 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 K 230 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 K 230 - G.h4s6 K 314 G.h4s6.08
Polar ICL3 K 230 - G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 K 236 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 142 - G.H5 I 343 G.H5.15
Hydrophobic TM5 L 226 5x65 G.H5 L 348 G.H5.20
Ionic TM6 K 234 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 234 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 234 6x30 G.H5 D 341 G.H5.13