MRGPRD - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7Y12

RESOLUTION

3.1 Å

REFERENCE

10.1038/S42003-022-03668-3

PUBLICATION DATE

July 20, 2022

3D VIEW

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LIGAND INTERACTIONS

3 interactions (Click to see)

LIGANDS

β-alanine - Agonist pubchem gtoplig chembl_ligand drugbank pubchem

PHYSIOLOGICAL LIGANDS

β-alanine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 213 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 213 - G.H5 K 345 G.H5.17
Polar H8 R 282 8x49 G.H5 N 346 G.H5.18
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL4 G 280 - G.H5 C 351 G.H5.23
Hydrophobic ICL4 G 280 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 G 280 - G.H5 G 352 G.H5.24
Hydrophobic TM6 L 219 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 219 6x33 G.H5 L 348 G.H5.20
Ionic H8 R 282 8x49 G.H5 D 350 G.H5.22
Polar H8 R 282 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 282 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 282 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL1 F 61 - G.H5 D 350 G.H5.22
Polar ICL2 C 135 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 C 135 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 134 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 134 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 131 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 I 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 L 201 5x59 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 353 G.H5.25
Polar ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 218 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 218 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 R 218 6x32 G.H5 G 352 G.H5.24
Polar ICL1 N 59 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 N 59 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 N 59 - G.H5 D 350 G.H5.22
Polar ICL2 K 134 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 133 34x53 G.H5 N 347 G.H5.19
Polar TM6 R 218 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 218 6x32 G.H5 F 354 G.H5.26
Polar TM6 R 218 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 218 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 218 6x32 G.H5 L 353 G.H5.25
Polar ICL3 R 214 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 R 214 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 214 - G.h4s6 K 314 G.h4s6.08
Polar TM3 S 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 347 G.H5.19
Polar ICL2 K 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 134 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 H 136 34x56 G.hns1 R 32 G.hns1.03
Polar TM6 L 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 219 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 222 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 222 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 P 216 6x30 G.H5 F 354 G.H5.26
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 H 136 34x56 G.s2s3 D 193 G.s2s3.02
Polar ICL3 R 214 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 R 214 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 R 214 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 R 213 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 213 - G.H5 F 354 G.H5.26
Polar ICL2 R 137 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 137 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL1 F 61 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 F 61 - G.H5 C 351 G.H5.23
Ionic TM4 R 139 4x39 G.HN E 28 G.HN.52
Polar TM4 R 139 4x39 G.HN E 28 G.HN.52
Hydrophobic ICL2 I 131 34x51 G.H5 I 343 G.H5.15
Hydrophobic H8 R 282 8x49 G.H5 K 349 G.H5.21