H3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YUU

RESOLUTION

2.7 Å

REFERENCE

10.1002/ADVS.202310120

PUBLICATION DATE

June 5, 2024

3D VIEW

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LIGAND INTERACTIONS

16 interactions (Click to see)

LIGANDS

histamine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank gtoplig

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 69 2x39 G.H5 C 351 G.H5.23
Polar ICL2 R 143 34x54 G.hns1 R 32 G.hns1.03
Polar TM5 R 232 5x72 G.S6 I 319 G.S6.01
Van-der-waals TM5 R 232 5x72 G.S6 I 319 G.S6.01
Polar TM3 S 135 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 135 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 135 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 139 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 139 34x50 G.H5 I 344 G.H5.16
Polar TM3 D 131 3x49 G.H5 C 351 G.H5.23
Polar H8 H 416 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 H 416 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 H 416 8x47 G.H5 D 350 G.H5.22
Ionic TM6 R 349 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 349 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 349 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL2 R 143 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 R 232 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 232 5x72 G.S6 Y 320 G.S6.02
Polar TM3 S 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 135 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 143 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 A 144 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 V 356 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 356 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Polar ICL2 A 139 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 A 139 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 F 348 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 F 348 6x25 G.h4s6 D 315 G.h4s6.09
Polar ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Polar H8 H 416 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 416 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 416 8x47 G.H5 C 351 G.H5.23
Polar ICL2 R 143 34x54 G.S1 E 33 G.S1.01
Ionic TM6 R 349 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 349 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM3 R 132 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 140 34x51 G.S3 L 194 G.S3.01
Polar TM6 K 355 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 355 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 136 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 225 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 225 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 F 344 6x21 G.h4s6 K 314 G.h4s6.08
Polar TM6 R 352 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 352 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 352 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 144 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 144 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 D 353 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 D 353 6x30 G.H5 F 354 G.H5.26
Hydrophobic H8 H 417 8x48 G.H5 D 350 G.H5.22
Polar ICL2 S 141 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 141 34x52 G.hns1 R 32 G.hns1.03
Polar H8 H 417 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 H 417 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 H 417 8x48 G.H5 K 349 G.H5.21
Polar TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 136 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 139 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 221 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 356 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 356 6x33 G.H5 L 353 G.H5.25
Ionic TM5 R 232 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 232 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 232 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 228 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 228 5x68 G.H5 I 344 G.H5.16
Ionic TM5 R 228 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 228 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 228 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 228 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 228 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 360 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 360 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 225 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 225 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 140 34x51 G.H5 I 343 G.H5.15