TAS2R14 - Gi1

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 10, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

flufenamic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 M 205 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 111 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 M 212 5x72 G.H5 A 338 G.H5.10
Hydrophobic H8 K 285 8x48 G.H5 F 354 G.H5.26
Ionic TM5 R 209 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 209 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 L 353 G.H5.25
Hydrophobic H8 K 285 8x48 G.H5 L 353 G.H5.25
Polar TM5 H 208 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 H 208 5x68 G.H5 T 340 G.H5.12
Hydrophobic H8 N 284 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 284 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 F 106 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 208 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 208 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 T 215 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 R 209 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 209 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Ionic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar H8 R 288 8x51 G.H5 L 353 G.H5.25
Van-der-waals H8 R 288 8x51 G.H5 L 353 G.H5.25
Polar TM5 T 215 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 T 215 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 T 215 5x75 G.H5 D 337 G.H5.09
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 N 113 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 W 124 - G.HN E 28 G.HN.52
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Polar H8 K 285 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 K 285 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 K 285 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM5 M 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Polar ICL2 N 113 - G.H5 T 340 G.H5.12
Hydrophobic TM5 M 212 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 212 5x72 G.H5 D 337 G.H5.09
Aromatic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 124 - G.hns1 R 32 G.hns1.03