CB1 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WV9

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41589-022-01038-Y

PUBLICATION DATE

June 15, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

15 interactions (Click to see)

LIGANDS

CP55940 - Agonist pubchem gtoplig chembl_ligand gtoplig ,

6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole - PAM pubchem

PHYSIOLOGICAL LIGANDS

anandamide, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 315 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 K 315 - G.S6 I 320 G.S6.01
Hydrophobic TM3 R 214 3x50 G.H5 C 352 G.H5.23
Polar TM2 S 152 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 152 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 221 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 221 - G.H5 I 345 G.H5.16
Hydrophobic TM5 H 304 5x68 G.H5 I 345 G.H5.16
Polar TM3 D 213 3x49 G.H5 C 352 G.H5.23
Hydrophobic TM3 D 213 3x49 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 221 - G.H5 I 344 G.H5.15
Hydrophobic ICL3 Q 314 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 Q 314 - G.S6 Y 321 G.S6.02
Hydrophobic H8 S 401 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 S 401 8x47 G.H5 F 355 G.H5.26
Hydrophobic TM2 R 150 2x37 G.H5 D 351 G.H5.22
Ionic ICL3 K 315 - G.H4 E 309 G.H4.16
Ionic TM5 R 311 5x75 G.H5 D 338 G.H5.09
Polar ICL3 K 315 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 K 315 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 K 315 - G.S6 Y 321 G.S6.02
Polar TM3 S 217 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 S 217 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 S 217 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 214 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL3 T 313 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 T 313 - G.H5 F 335 G.H5.06
Hydrophobic TM6 M 337 6x29 G.H5 I 345 G.H5.16
Hydrophobic TM6 R 340 6x32 G.H5 F 355 G.H5.26
Polar H8 S 401 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 S 401 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 401 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM6 M 337 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 218 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 349 G.H5.20
Hydrophobic H8 D 403 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 D 403 8x49 G.H5 K 350 G.H5.21
Hydrophobic ICL2 R 226 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 226 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 345 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL3 K 315 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 K 315 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL4 R 400 - G.H5 F 355 G.H5.26
Hydrophobic TM3 I 218 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL3 Q 314 - G.S6 T 322 G.S6.03
Van-der-waals ICL3 Q 314 - G.S6 T 322 G.S6.03
Hydrophobic TM6 M 337 6x29 G.H5 F 355 G.H5.26
Polar H8 K 402 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 K 402 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 K 402 8x48 G.H5 F 355 G.H5.26
Hydrophobic TM6 L 341 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM5 I 297 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 M 308 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 M 308 5x72 G.H5 D 342 G.H5.13
Hydrophobic ICL2 L 222 - G.S3 L 195 G.S3.01
Polar ICL2 P 221 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 221 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 221 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 Y 224 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 222 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 222 - G.H5 I 344 G.H5.15
Polar TM6 T 344 6x36 G.H5 L 354 G.H5.25
Polar ICL2 K 225 - G.H5 N 348 G.H5.19
Polar ICL2 Y 224 - G.H5 C 352 G.H5.23
Hydrophobic ICL2 Y 224 - G.H5 C 352 G.H5.23
Van-der-waals ICL2 Y 224 - G.H5 C 352 G.H5.23
Hydrophobic TM6 L 341 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 341 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 341 6x33 G.H5 L 349 G.H5.20
Polar TM3 S 217 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 217 3x53 G.H5 N 348 G.H5.19