Refined structure (7T6B) of G13 - S1P2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (59.7%), 152 from model (40.3%)
Residue sidechains - 196 from structure (52.0%), 181 from model (48.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 A G.HN.02 AF2 AF2
G.HN 3 D G.HN.03 Structure AF2
G.HN 4 F G.HN.04 Structure AF2
G.HN 5 L G.HN.05 Structure Structure
G.HN 6 P G.HN.06 Structure AF2
G.HN 7 S G.HN.09 Structure AF2
G.HN 8 R G.HN.10 Structure AF2
G.HN 9 S G.HN.11 Structure AF2
G.HN 10 V G.HN.12 Structure AF2
G.HN 11 L G.HN.13 Structure AF2
G.HN 12 S G.HN.14 Structure AF2
G.HN 13 V G.HN.15 Structure Structure
G.HN 14 C G.HN.16 Structure AF2
G.HN 15 F G.HN.17 Structure AF2
G.HN 16 P G.HN.18 Structure AF2
G.HN 17 G G.HN.19 Structure AF2
G.HN 18 C G.HN.20 Structure AF2
G.HN 19 L G.HN.21 Structure AF2
G.HN 20 L G.HN.22 Structure AF2
G.HN 21 T G.HN.23 Structure AF2
G.HN 22 S G.HN.24 Structure AF2
G.HN 23 G G.HN.25 Structure AF2
G.HN 24 E G.HN.33 Structure AF2
G.HN 25 A G.HN.34 Structure AF2
G.HN 26 E G.HN.35 Structure AF2
G.HN 27 Q G.HN.36 Structure AF2
G.HN 28 Q G.HN.37 Structure AF2
G.HN 29 R G.HN.38 Structure AF2
G.HN 30 K G.HN.39 Structure AF2
G.HN 31 S G.HN.40 Structure AF2
G.HN 32 K G.HN.41 AF2 AF2
G.HN 33 E G.HN.42 AF2 AF2
G.HN 34 I G.HN.43 AF2 AF2
G.HN 35 D G.HN.44 AF2 AF2
G.HN 36 K G.HN.45 AF2 AF2
G.HN 37 C G.HN.46 AF2 AF2
G.HN 38 L G.HN.47 AF2 AF2
G.HN 39 S G.HN.48 AF2 AF2
G.HN 40 R G.HN.49 AF2 AF2
G.HN 41 E G.HN.50 AF2 AF2
G.HN 42 K G.HN.51 AF2 AF2
G.HN 43 T G.HN.52 AF2 AF2
G.HN 44 Y G.HN.53 AF2 AF2
G.hns1 45 V G.hns1.01 AF2 AF2
G.hns1 46 K G.hns1.02 AF2 AF2
G.hns1 47 R G.hns1.03 Structure Structure
G.S1 48 L G.S1.01 Structure Structure
G.S1 49 V G.S1.02 Structure Structure
G.S1 50 K G.S1.03 Structure Structure
G.S1 51 I G.S1.04 Structure Structure
G.S1 52 L G.S1.05 Structure Structure
G.S1 53 L G.S1.06 Structure Structure
G.S1 54 L G.S1.07 Structure Structure
G.s1h1 55 G G.s1h1.01 Structure Structure
G.s1h1 56 A G.s1h1.02 Structure Structure
G.s1h1 57 G G.s1h1.03 Structure Structure
G.s1h1 58 E G.s1h1.04 Structure Structure
G.s1h1 59 S G.s1h1.05 Structure Structure
G.s1h1 60 G G.s1h1.06 Structure Structure
G.H1 61 K G.H1.01 Structure Structure
G.H1 62 S G.H1.02 Structure Structure
G.H1 63 T G.H1.03 Structure Structure
G.H1 64 F G.H1.04 Structure Structure
G.H1 65 L G.H1.05 Structure Structure
G.H1 66 K G.H1.06 Structure Structure
G.H1 67 Q G.H1.07 Structure Structure
G.H1 68 M G.H1.08 Structure Structure
G.H1 69 R G.H1.09 Structure Structure
G.H1 70 I G.H1.10 Structure Structure
G.H1 71 I G.H1.11 Structure Structure
G.H1 72 H G.H1.12 Structure Structure
G.h1ha 73 G G.h1ha.01 AF2 AF2
G.h1ha 74 Q G.h1ha.02 AF2 AF2
G.h1ha 75 D G.h1ha.03 AF2 AF2
G.h1ha 76 F G.h1ha.04 AF2 AF2
G.h1ha 77 D G.h1ha.05 AF2 AF2
H.HA 78 Q H.HA.01 AF2 AF2
H.HA 79 R H.HA.02 AF2 AF2
H.HA 80 A H.HA.03 AF2 AF2
H.HA 81 R H.HA.04 AF2 AF2
H.HA 82 E H.HA.05 AF2 AF2
H.HA 83 E H.HA.06 AF2 AF2
H.HA 84 F H.HA.07 AF2 AF2
H.HA 85 R H.HA.08 AF2 AF2
H.HA 86 P H.HA.09 AF2 AF2
H.HA 87 T H.HA.10 AF2 AF2
H.HA 88 I H.HA.11 AF2 AF2
H.HA 89 Y H.HA.12 AF2 AF2
H.HA 90 S H.HA.13 AF2 AF2
H.HA 91 N H.HA.14 AF2 AF2
H.HA 92 V H.HA.15 AF2 AF2
H.HA 93 I H.HA.16 AF2 AF2
H.HA 94 K H.HA.17 AF2 AF2
H.HA 95 G H.HA.18 AF2 AF2
H.HA 96 M H.HA.19 AF2 AF2
H.HA 97 R H.HA.20 AF2 AF2
H.HA 98 V H.HA.21 AF2 AF2
H.HA 99 L H.HA.22 AF2 AF2
H.HA 100 V H.HA.23 AF2 AF2
H.HA 101 D H.HA.24 AF2 AF2
H.HA 102 A H.HA.25 AF2 AF2
H.HA 103 R H.HA.26 AF2 AF2
H.HA 104 E H.HA.27 AF2 AF2
H.HA 105 K H.HA.28 AF2 AF2
H.HA 106 L H.HA.29 AF2 AF2
H.hahb 107 H H.hahb.01 AF2 AF2
H.hahb 108 I H.hahb.04 AF2 AF2
H.hahb 109 P H.hahb.05 AF2 AF2
H.hahb 110 W H.hahb.06 AF2 AF2
H.hahb 111 G H.hahb.07 AF2 AF2
H.hahb 112 D H.hahb.08 AF2 AF2
H.hahb 113 N H.hahb.09 AF2 AF2
H.HB 114 S H.HB.01 AF2 AF2
H.HB 115 N H.HB.02 AF2 AF2
H.HB 116 Q H.HB.03 AF2 AF2
H.HB 117 Q H.HB.04 AF2 AF2
H.HB 118 H H.HB.05 AF2 AF2
H.HB 119 G H.HB.06 AF2 AF2
H.HB 120 D H.HB.07 AF2 AF2
H.HB 121 K H.HB.08 AF2 AF2
H.HB 122 M H.HB.09 AF2 AF2
H.HB 123 M H.HB.10 AF2 AF2
H.HB 124 S H.HB.11 AF2 AF2
H.HB 125 F H.HB.12 AF2 AF2
H.HB 126 D H.HB.13 AF2 AF2
H.HB 127 T H.HB.14 AF2 AF2
H.hbhc 128 R H.hbhc.01 AF2 AF2
H.hbhc 129 A H.hbhc.02 AF2 AF2
H.hbhc 130 P H.hbhc.03 AF2 AF2
H.hbhc 131 M H.hbhc.04 AF2 AF2
H.hbhc 132 A H.hbhc.05 AF2 AF2
H.hbhc 133 A H.hbhc.06 AF2 AF2
H.hbhc 134 Q H.hbhc.07 AF2 AF2
H.hbhc 135 G H.hbhc.08 AF2 AF2
H.hbhc 136 M H.hbhc.09 AF2 AF2
H.hbhc 137 V H.hbhc.10 AF2 AF2
H.hbhc 138 E H.hbhc.11 AF2 AF2
H.hbhc 139 T H.hbhc.12 AF2 AF2
H.hbhc 140 R H.hbhc.13 AF2 AF2
H.hbhc 141 V H.hbhc.14 AF2 AF2
H.hbhc 142 F H.hbhc.15 AF2 AF2
H.HC 143 L H.HC.01 AF2 AF2
H.HC 144 Q H.HC.02 AF2 AF2
H.HC 145 Y H.HC.03 AF2 AF2
H.HC 146 L H.HC.04 AF2 AF2
H.HC 147 P H.HC.05 AF2 AF2
H.HC 148 A H.HC.06 AF2 AF2
H.HC 149 I H.HC.07 AF2 AF2
H.HC 150 R H.HC.08 AF2 AF2
H.HC 151 A H.HC.09 AF2 AF2
H.HC 152 L H.HC.10 AF2 AF2
H.HC 153 W H.HC.11 AF2 AF2
H.HC 154 A H.HC.12 AF2 AF2
H.hchd 155 D H.hchd.01 AF2 AF2
H.HD 156 S H.HD.01 AF2 AF2
H.HD 157 G H.HD.02 AF2 AF2
H.HD 158 I H.HD.03 AF2 AF2
H.HD 159 Q H.HD.04 AF2 AF2
H.HD 160 N H.HD.05 AF2 AF2
H.HD 161 A H.HD.06 AF2 AF2
H.HD 162 Y H.HD.07 AF2 AF2
H.HD 163 D H.HD.08 AF2 AF2
H.HD 164 R H.HD.09 AF2 AF2
H.HD 165 R H.HD.10 AF2 AF2
H.HD 166 R H.HD.11 AF2 AF2
H.HD 167 E H.HD.12 AF2 AF2
H.hdhe 168 F H.hdhe.01 AF2 AF2
H.hdhe 169 Q H.hdhe.02 AF2 AF2
H.hdhe 170 L H.hdhe.03 AF2 AF2
H.hdhe 171 G H.hdhe.04 AF2 AF2
H.hdhe 172 E H.hdhe.05 AF2 AF2
H.HE 173 S H.HE.01 AF2 AF2
H.HE 174 V H.HE.02 AF2 AF2
H.HE 175 K H.HE.03 AF2 AF2
H.HE 176 Y H.HE.04 AF2 AF2
H.HE 177 F H.HE.05 AF2 AF2
H.HE 178 L H.HE.06 AF2 AF2
H.HE 179 D H.HE.07 AF2 AF2
H.HE 180 N H.HE.08 AF2 AF2
H.HE 181 L H.HE.09 AF2 AF2
H.HE 182 D H.HE.10 AF2 AF2
H.HE 183 K H.HE.11 AF2 AF2
H.HE 184 L H.HE.12 AF2 AF2
H.HE 185 G H.HE.13 AF2 AF2
H.hehf 186 E H.hehf.01 AF2 AF2
H.hehf 187 P H.hehf.02 AF2 AF2
H.hehf 188 D H.hehf.03 AF2 AF2
H.hehf 189 Y H.hehf.04 AF2 AF2
H.hehf 190 I H.hehf.05 AF2 AF2
H.hehf 191 P H.hehf.06 AF2 AF2
H.hehf 192 S H.hehf.07 AF2 AF2
H.HF 193 Q H.HF.01 AF2 AF2
H.HF 194 Q H.HF.02 AF2 AF2
H.HF 195 D H.HF.03 AF2 AF2
H.HF 196 I H.HF.04 AF2 AF2
H.HF 197 L H.HF.05 AF2 AF2
H.HF 198 L H.HF.06 AF2 AF2
G.hfs2 199 A G.hfs2.01 AF2 AF2
G.hfs2 200 R G.hfs2.02 AF2 AF2
G.hfs2 201 R G.hfs2.03 AF2 AF2
G.hfs2 202 P G.hfs2.04 AF2 AF2
G.hfs2 203 T G.hfs2.05 AF2 AF2
G.hfs2 204 K G.hfs2.06 Structure Structure
G.hfs2 205 G G.hfs2.07 Structure Structure
G.S2 206 I G.S2.01 Structure Structure
G.S2 207 H G.S2.02 Structure Structure
G.S2 208 E G.S2.03 Structure Structure
G.S2 209 Y G.S2.04 Structure Structure
G.S2 210 D G.S2.05 Structure Structure
G.S2 211 F G.S2.06 Structure Structure
G.S2 212 E G.S2.07 Structure Structure
G.S2 213 I G.S2.08 Structure Structure
G.s2s3 214 K G.s2s3.01 Structure Structure
G.s2s3 215 N G.s2s3.02 Structure Structure
G.S3 216 V G.S3.01 Structure Structure
G.S3 217 P G.S3.02 Structure Structure
G.S3 218 F G.S3.03 Structure Structure
G.S3 219 K G.S3.04 Structure Structure
G.S3 220 M G.S3.05 Structure Structure
G.S3 221 V G.S3.06 Structure Structure
G.S3 222 D G.S3.07 Structure Structure
G.S3 223 V G.S3.08 Structure Structure
G.s3h2 224 G G.s3h2.01 Structure Structure
G.s3h2 225 G G.s3h2.02 Structure Structure
G.s3h2 226 Q G.s3h2.03 AF2 AF2
G.H2 227 R G.H2.01 AF2 AF2
G.H2 228 S G.H2.02 AF2 AF2
G.H2 229 E G.H2.03 AF2 AF2
G.H2 230 R G.H2.04 Structure Structure
G.H2 231 K G.H2.05 Structure Structure
G.H2 232 R G.H2.06 Structure Structure
G.H2 233 W G.H2.07 Structure Structure
G.H2 234 F G.H2.08 Structure Structure
G.H2 235 E G.H2.09 Structure Structure
G.H2 236 C G.H2.10 Structure Structure
G.h2s4 237 F G.h2s4.01 Structure Structure
G.h2s4 238 D G.h2s4.02 Structure Structure
G.h2s4 239 S G.h2s4.03 Structure Structure
G.h2s4 240 V G.h2s4.04 Structure Structure
G.h2s4 241 T G.h2s4.05 Structure Structure
G.S4 242 S G.S4.01 Structure Structure
G.S4 243 I G.S4.02 Structure Structure
G.S4 244 L G.S4.03 Structure Structure
G.S4 245 F G.S4.04 Structure Structure
G.S4 246 L G.S4.05 Structure Structure
G.S4 247 V G.S4.06 Structure Structure
G.S4 248 S G.S4.07 Structure Structure
G.s4h3 249 S G.s4h3.01 Structure Structure
G.s4h3 250 S G.s4h3.02 Structure Structure
G.s4h3 251 E G.s4h3.03 Structure Structure
G.s4h3 252 F G.s4h3.04 Structure Structure
G.s4h3 253 D G.s4h3.05 Structure Structure
G.s4h3 254 Q G.s4h3.06 Structure Structure
G.s4h3 255 V G.s4h3.07 Structure Structure
G.s4h3 256 L G.s4h3.08 Structure Structure
G.s4h3 257 M G.s4h3.09 Structure Structure
G.s4h3 258 E G.s4h3.10 Structure Structure
G.s4h3 259 D G.s4h3.11 Structure Structure
G.s4h3 260 R G.s4h3.12 Structure Structure
G.s4h3 261 L G.s4h3.13 Structure Structure
G.s4h3 262 T G.s4h3.14 Structure Structure
G.s4h3 263 N G.s4h3.15 Structure Structure
G.H3 264 R G.H3.01 Structure Structure
G.H3 265 L G.H3.02 Structure Structure
G.H3 266 T G.H3.03 Structure Structure
G.H3 267 E G.H3.04 Structure Structure
G.H3 268 S G.H3.05 Structure Structure
G.H3 269 L G.H3.06 Structure Structure
G.H3 270 N G.H3.07 Structure Structure
G.H3 271 I G.H3.08 Structure Structure
G.H3 272 F G.H3.09 Structure Structure
G.H3 273 E G.H3.10 Structure Structure
G.H3 274 T G.H3.11 Structure Structure
G.H3 275 I G.H3.12 Structure Structure
G.H3 276 V G.H3.13 Structure Structure
G.H3 277 N G.H3.14 Structure Structure
G.H3 278 N G.H3.15 Structure Structure
G.H3 279 R G.H3.16 Structure Structure
G.H3 280 V G.H3.17 Structure Structure
G.H3 281 F G.H3.18 Structure Structure
G.h3s5 282 S G.h3s5.01 Structure Structure
G.h3s5 283 N G.h3s5.02 Structure Structure
G.h3s5 284 V G.h3s5.03 Structure Structure
G.S5 285 S G.S5.01 Structure Structure
G.S5 286 I G.S5.02 Structure Structure
G.S5 287 I G.S5.03 Structure Structure
G.S5 288 L G.S5.04 Structure Structure
G.S5 289 F G.S5.05 Structure Structure
G.S5 290 L G.S5.06 Structure Structure
G.S5 291 N G.S5.07 Structure Structure
G.s5hg 292 K G.s5hg.01 Structure Structure
G.HG 293 T G.HG.01 Structure Structure
G.HG 294 D G.HG.02 Structure Structure
G.HG 295 L G.HG.03 Structure Structure
G.HG 296 L G.HG.04 Structure Structure
G.HG 297 E G.HG.05 Structure Structure
G.HG 298 E G.HG.06 Structure Structure
G.HG 299 K G.HG.07 Structure Structure
G.HG 300 V G.HG.08 Structure Structure
G.HG 301 Q G.HG.09 Structure Structure
G.HG 302 I G.HG.12 Structure AF2
G.HG 303 V G.HG.13 Structure Structure
G.HG 304 S G.HG.14 Structure Structure
G.HG 305 I G.HG.15 Structure Structure
G.HG 306 K G.HG.16 Structure Structure
G.HG 307 D G.HG.17 Structure Structure
G.hgh4 308 Y G.hgh4.01 Structure Structure
G.hgh4 309 F G.hgh4.02 Structure Structure
G.hgh4 310 L G.hgh4.03 Structure Structure
G.hgh4 311 E G.hgh4.04 Structure Structure
G.hgh4 312 F G.hgh4.05 Structure Structure
G.hgh4 313 E G.hgh4.06 Structure Structure
G.hgh4 314 G G.hgh4.07 Structure Structure
G.hgh4 315 D G.hgh4.08 Structure Structure
G.H4 316 P G.H4.01 Structure Structure
G.H4 317 H G.H4.02 Structure Structure
G.H4 318 C G.H4.03 Structure Structure
G.H4 319 L G.H4.04 Structure Structure
G.H4 320 R G.H4.05 Structure Structure
G.H4 321 D G.H4.06 Structure Structure
G.H4 322 V G.H4.07 Structure Structure
G.H4 323 Q G.H4.08 Structure Structure
G.H4 324 K G.H4.09 Structure Structure
G.H4 325 F G.H4.10 Structure Structure
G.H4 326 L G.H4.11 Structure Structure
G.H4 327 V G.H4.12 Structure Structure
G.H4 328 E G.H4.13 Structure Structure
G.H4 329 C G.H4.14 Structure Structure
G.H4 330 F G.H4.15 Structure Structure
G.H4 331 R G.H4.16 Structure Structure
G.H4 332 N G.H4.17 Structure AF2
G.h4s6 333 K G.h4s6.01 Structure Structure
G.h4s6 334 R G.h4s6.08 Structure Structure
G.h4s6 335 R G.h4s6.09 Structure Structure
G.h4s6 336 D G.h4s6.10 Structure Structure
G.h4s6 337 Q G.h4s6.11 Structure Structure
G.h4s6 338 Q G.h4s6.12 Structure Structure
G.h4s6 339 Q G.h4s6.13 Structure Structure
G.h4s6 340 K G.h4s6.19 Structure Structure
G.h4s6 341 P G.h4s6.20 Structure Structure
G.S6 342 L G.S6.01 Structure Structure
G.S6 343 Y G.S6.02 Structure Structure
G.S6 344 H G.S6.03 Structure Structure
G.S6 345 H G.S6.04 Structure Structure
G.S6 346 F G.S6.05 Structure Structure
G.s6h5 347 T G.s6h5.01 Structure Structure
G.s6h5 348 T G.s6h5.02 Structure Structure
G.s6h5 349 A G.s6h5.03 Structure Structure
G.s6h5 350 I G.s6h5.04 Structure Structure
G.s6h5 351 N G.s6h5.05 Structure Structure
G.H5 352 T G.H5.01 Structure Structure
G.H5 353 E G.H5.02 Structure Structure
G.H5 354 N G.H5.03 Structure Structure
G.H5 355 I G.H5.04 Structure Structure
G.H5 356 R G.H5.05 Structure Structure
G.H5 357 L G.H5.06 Structure Structure
G.H5 358 V G.H5.07 Structure Structure
G.H5 359 F G.H5.08 Structure Structure
G.H5 360 R G.H5.09 Structure Structure
G.H5 361 D G.H5.10 Structure Structure
G.H5 362 V G.H5.11 Structure Structure
G.H5 363 K G.H5.12 Structure Structure
G.H5 364 D G.H5.13 Structure Structure
G.H5 365 T G.H5.14 Structure Structure
G.H5 366 I G.H5.15 Structure Structure
G.H5 367 L G.H5.16 Structure Structure
G.H5 368 H G.H5.17 Structure Structure
G.H5 369 D G.H5.18 Structure Structure
G.H5 370 N G.H5.19 Structure Structure
G.H5 371 L G.H5.20 Structure Structure
G.H5 372 K G.H5.21 Structure Structure
G.H5 373 Q G.H5.22 Structure Structure
G.H5 374 L G.H5.23 Structure Structure
G.H5 375 M G.H5.24 Structure Structure
G.H5 376 L G.H5.25 Structure Structure
G.H5 377 Q G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 264 from structure (84.1%), 50 from model (15.9%)
Residue sidechains - 264 from structure (84.1%), 50 from model (15.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 Y - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 Y - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 N - Structure Structure
N-term 13 K - Structure Structure
N-term 14 V - Structure Structure
N-term 15 Q - Structure Structure
N-term 16 E - Structure Structure
N-term 17 H - Structure Structure
N-term 18 Y - Structure Structure
N-term 19 N - Structure Structure
N-term 20 Y - Structure Structure
N-term 21 T - Structure Structure
N-term 22 K - Structure Structure
N-term 23 E - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 T - AF2 AF2
N-term 28 Q - AF2 AF2
N-term 29 E - AF2 AF2
TM1 30 T 1.29x29 AF2 AF2
TM1 31 T 1.30x30 Structure Structure
TM1 32 S 1.31x31 Structure Structure
TM1 33 R 1.32x32 Structure Structure
TM1 34 Q 1.33x33 Structure Structure
TM1 35 V 1.34x34 Structure Structure
TM1 36 A 1.35x35 Structure Structure
TM1 37 S 1.36x36 Structure Structure
TM1 38 A 1.37x37 Structure Structure
TM1 39 F 1.38x38 Structure Structure
TM1 40 I 1.39x39 Structure Structure
TM1 41 V 1.40x40 Structure Structure
TM1 42 I 1.41x41 Structure Structure
TM1 43 L 1.42x42 Structure Structure
TM1 44 C 1.43x43 Structure Structure
TM1 45 C 1.44x44 Structure Structure
TM1 46 A 1.45x45 Structure Structure
TM1 47 I 1.46x46 Structure Structure
TM1 48 V 1.47x47 Structure Structure
TM1 49 V 1.48x48 Structure Structure
TM1 50 E 1.49x49 Structure Structure
TM1 51 N 1.50x50 Structure Structure
TM1 52 L 1.51x51 Structure Structure
TM1 53 L 1.52x52 Structure Structure
TM1 54 V 1.53x53 Structure Structure
TM1 55 L 1.54x54 Structure Structure
TM1 56 I 1.55x55 Structure Structure
TM1 57 A 1.56x56 Structure Structure
TM1 58 V 1.57x57 Structure Structure
TM1 59 A 1.58x58 Structure Structure
TM1 60 R 1.59x59 Structure Structure
TM1 61 N 1.60x60 Structure Structure
ICL1 62 S 12.48x48 Structure Structure
ICL1 63 K 12.49x49 Structure Structure
ICL1 64 F 12.50x50 Structure Structure
ICL1 65 H 12.51x51 Structure Structure
TM2 66 S 2.37x37 Structure Structure
TM2 67 A 2.38x38 Structure Structure
TM2 68 M 2.39x39 Structure Structure
TM2 69 Y 2.40x40 Structure Structure
TM2 70 L 2.41x41 Structure Structure
TM2 71 F 2.42x42 Structure Structure
TM2 72 L 2.43x43 Structure Structure
TM2 73 G 2.44x44 Structure Structure
TM2 74 N 2.45x45 Structure Structure
TM2 75 L 2.46x46 Structure Structure
TM2 76 A 2.47x47 Structure Structure
TM2 77 A 2.48x48 Structure Structure
TM2 78 S 2.49x49 Structure Structure
TM2 79 D 2.50x50 Structure Structure
TM2 80 L 2.51x51 Structure Structure
TM2 81 L 2.52x52 Structure Structure
TM2 82 A 2.53x53 Structure Structure
TM2 83 G 2.54x54 Structure Structure
TM2 84 V 2.55x55 Structure Structure
TM2 85 A 2.56x56 Structure Structure
TM2 86 F 2.57x57 Structure Structure
TM2 87 V 2.58x58 Structure Structure
TM2 88 A 2.59x59 Structure Structure
TM2 89 N 2.60x60 Structure Structure
TM2 90 T 2.61x61 Structure Structure
TM2 91 L 2.62x62 Structure Structure
TM2 92 L 2.63x63 Structure Structure
TM2 93 S 2.64x64 Structure Structure
ECL1 94 G 23.47x47 Structure Structure
ECL1 95 S 23.48x48 Structure Structure
ECL1 96 V 23.49x49 Structure Structure
ECL1 97 T 23.50x50 Structure Structure
ECL1 98 L 23.51x501 Structure Structure
ECL1 99 R 23.52x51 Structure Structure
ECL1 100 L 23.53x52 Structure Structure
TM3 101 T 3.21x21 Structure Structure
TM3 102 P 3.22x22 Structure Structure
TM3 103 V 3.23x23 Structure Structure
TM3 104 Q 3.24x24 Structure Structure
TM3 105 W 3.25x25 Structure Structure
TM3 106 F 3.26x26 Structure Structure
TM3 107 A 3.27x27 Structure Structure
TM3 108 R 3.28x28 Structure Structure
TM3 109 E 3.29x29 Structure Structure
TM3 110 G 3.30x30 Structure Structure
TM3 111 S 3.31x31 Structure Structure
TM3 112 A 3.32x32 Structure Structure
TM3 113 F 3.33x33 Structure Structure
TM3 114 I 3.34x34 Structure Structure
TM3 115 T 3.35x35 Structure Structure
TM3 116 L 3.36x36 Structure Structure
TM3 117 S 3.37x37 Structure Structure
TM3 118 A 3.38x38 Structure Structure
TM3 119 S 3.39x39 Structure Structure
TM3 120 V 3.40x40 Structure Structure
TM3 121 F 3.41x41 Structure Structure
TM3 122 S 3.42x42 Structure Structure
TM3 123 L 3.43x43 Structure Structure
TM3 124 L 3.44x44 Structure Structure
TM3 125 A 3.45x45 Structure Structure
TM3 126 I 3.46x46 Structure Structure
TM3 127 A 3.47x47 Structure Structure
TM3 128 I 3.48x48 Structure Structure
TM3 129 E 3.49x49 Structure Structure
TM3 130 R 3.50x50 Structure Structure
TM3 131 H 3.51x51 Structure Structure
TM3 132 V 3.52x52 Structure Structure
TM3 133 A 3.53x53 Structure Structure
TM3 134 I 3.54x54 Structure Structure
TM3 135 A 3.55x55 Structure Structure
TM3 136 K 3.56x56 Structure Structure
ICL2 137 V 34.50x50 Structure Structure
ICL2 138 K 34.51x51 Structure Structure
ICL2 139 L 34.52x52 Structure Structure
ICL2 140 Y 34.53x53 Structure Structure
ICL2 141 G 34.54x54 Structure Structure
ICL2 142 S 34.55x55 Structure Structure
ICL2 143 D 34.56x56 Structure Structure
TM4 144 K 4.38x38 Structure Structure
TM4 145 S 4.39x39 Structure Structure
TM4 146 C 4.40x40 Structure Structure
TM4 147 R 4.41x41 Structure Structure
TM4 148 M 4.42x42 Structure Structure
TM4 149 L 4.43x43 Structure Structure
TM4 150 L 4.44x44 Structure Structure
TM4 151 L 4.45x45 Structure Structure
TM4 152 I 4.46x46 Structure Structure
TM4 153 G 4.47x47 Structure Structure
TM4 154 A 4.48x48 Structure Structure
TM4 155 S 4.49x49 Structure Structure
TM4 156 W 4.50x50 Structure Structure
TM4 157 L 4.51x51 Structure Structure
TM4 158 I 4.52x52 Structure Structure
TM4 159 S 4.53x53 Structure Structure
TM4 160 L 4.54x54 Structure Structure
TM4 161 V 4.55x55 Structure Structure
TM4 162 L 4.56x56 Structure Structure
TM4 163 G 4.57x57 Structure Structure
TM4 164 G 4.58x58 Structure Structure
TM4 165 L 4.59x59 Structure Structure
TM4 166 P 4.60x60 Structure Structure
TM4 167 I 4.61x61 Structure Structure
TM4 168 L 4.62x62 Structure Structure
TM4 169 G 4.63x63 Structure Structure
ECL2 170 W - Structure Structure
ECL2 171 N - Structure Structure
ECL2 172 C - Structure Structure
ECL2 173 L - Structure Structure
ECL2 174 G - Structure Structure
ECL2 175 H - Structure Structure
ECL2 176 L - Structure Structure
ECL2 177 E - Structure Structure
ECL2 178 A - Structure Structure
ECL2 179 C - Structure Structure
ECL2 180 S - Structure Structure
ECL2 181 T - Structure Structure
ECL2 182 V - Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 P - Structure Structure
ECL2 185 L - Structure Structure
ECL2 186 Y - Structure Structure
TM5 187 A 5.36x36 Structure Structure
TM5 188 K 5.37x37 Structure Structure
TM5 189 H 5.38x38 Structure Structure
TM5 190 Y 5.39x39 Structure Structure
TM5 191 V 5.40x40 Structure Structure
TM5 192 L 5.41x41 Structure Structure
TM5 193 C 5.42x42 Structure Structure
TM5 194 V 5.43x43 Structure Structure
TM5 195 V 5.44x44 Structure Structure
TM5 196 T 5.45x45 Structure Structure
TM5 197 I 5.46x46 Structure Structure
TM5 198 F 5.47x47 Structure Structure
TM5 199 S 5.48x48 Structure Structure
TM5 200 I 5.49x49 Structure Structure
TM5 201 I 5.50x50 Structure Structure
TM5 202 L 5.51x51 Structure Structure
TM5 203 L 5.52x52 Structure Structure
TM5 204 A 5.53x53 Structure Structure
TM5 205 I 5.54x54 Structure Structure
TM5 206 V 5.55x55 Structure Structure
TM5 207 A 5.56x56 Structure Structure
TM5 208 L 5.57x57 Structure Structure
TM5 209 Y 5.58x58 Structure Structure
TM5 210 V 5.59x59 Structure Structure
TM5 211 R 5.60x60 Structure Structure
TM5 212 I 5.61x61 Structure Structure
TM5 213 Y 5.62x62 Structure Structure
TM5 214 C 5.63x63 Structure Structure
TM5 215 V 5.64x64 Structure Structure
TM5 216 V 5.65x65 Structure Structure
TM5 217 R 5.66x66 Structure Structure
TM5 218 S 5.67x67 Structure Structure
TM5 219 S 5.68x68 Structure Structure
ICL3 220 H - AF2 AF2
ICL3 221 A - AF2 AF2
ICL3 222 D - AF2 AF2
ICL3 223 M - AF2 AF2
TM6 224 A 6.26x26 AF2 AF2
TM6 225 A 6.27x27 AF2 AF2
TM6 226 P 6.28x28 AF2 AF2
TM6 227 Q 6.29x29 Structure Structure
TM6 228 T 6.30x30 Structure Structure
TM6 229 L 6.31x31 Structure Structure
TM6 230 A 6.32x32 Structure Structure
TM6 231 L 6.33x33 Structure Structure
TM6 232 L 6.34x34 Structure Structure
TM6 233 K 6.35x35 Structure Structure
TM6 234 T 6.36x36 Structure Structure
TM6 235 V 6.37x37 Structure Structure
TM6 236 T 6.38x38 Structure Structure
TM6 237 I 6.39x39 Structure Structure
TM6 238 V 6.40x40 Structure Structure
TM6 239 L 6.41x41 Structure Structure
TM6 240 G 6.42x42 Structure Structure
TM6 241 V 6.43x43 Structure Structure
TM6 242 F 6.44x44 Structure Structure
TM6 243 I 6.45x45 Structure Structure
TM6 244 V 6.46x46 Structure Structure
TM6 245 C 6.47x47 Structure Structure
TM6 246 W 6.48x48 Structure Structure
TM6 247 L 6.49x49 Structure Structure
TM6 248 P 6.50x50 Structure Structure
TM6 249 A 6.51x51 Structure Structure
TM6 250 F 6.52x52 Structure Structure
TM6 251 S 6.53x53 Structure Structure
TM6 252 I 6.54x54 Structure Structure
TM6 253 L 6.55x55 Structure Structure
TM6 254 L 6.56x56 Structure Structure
TM6 255 L 6.57x57 Structure Structure
TM6 256 D 6.58x58 Structure Structure
TM6 257 Y 6.59x59 Structure Structure
TM6 258 A 6.60x60 Structure Structure
TM6 259 C 6.61x61 Structure Structure
ECL3 260 P - Structure Structure
ECL3 261 V - Structure Structure
ECL3 262 H - Structure Structure
ECL3 263 S - Structure Structure
ECL3 264 C - Structure Structure
TM7 265 P 7.30x29 Structure Structure
TM7 266 I 7.31x30 Structure Structure
TM7 267 L 7.32x31 Structure Structure
TM7 268 Y 7.33x32 Structure Structure
TM7 269 K 7.34x33 Structure Structure
TM7 270 A 7.35x34 Structure Structure
TM7 271 H 7.36x35 Structure Structure
TM7 272 Y 7.37x36 Structure Structure
TM7 273 F 7.38x37 Structure Structure
TM7 274 F 7.39x38 Structure Structure
TM7 275 A 7.40x39 Structure Structure
TM7 276 V 7.41x40 Structure Structure
TM7 277 S 7.42x41 Structure Structure
TM7 278 T 7.43x42 Structure Structure
TM7 279 L 7.44x43 Structure Structure
TM7 280 N 7.45x45 Structure Structure
TM7 281 S 7.46x46 Structure Structure
TM7 282 L 7.47x47 Structure Structure
TM7 283 L 7.48x48 Structure Structure
TM7 284 N 7.49x49 Structure Structure
TM7 285 P 7.50x50 Structure Structure
TM7 286 V 7.51x51 Structure Structure
TM7 287 I 7.52x52 Structure Structure
TM7 288 Y 7.53x53 Structure Structure
TM7 289 T 7.54x54 Structure Structure
TM7 290 W 7.55x55 Structure Structure
TM7 291 R 7.56x56 AF2 AF2
H8 292 S 8.47x47 AF2 AF2
H8 293 R 8.48x48 AF2 AF2
H8 294 D 8.49x49 AF2 AF2
H8 295 L 8.50x50 AF2 AF2
H8 296 R 8.51x51 AF2 AF2
H8 297 R 8.52x52 AF2 AF2
H8 298 E 8.53x53 AF2 AF2
H8 299 V 8.54x54 AF2 AF2
H8 300 L 8.55x55 AF2 AF2
H8 301 R 8.56x56 AF2 AF2
H8 302 P 8.57x57 AF2 AF2
H8 303 L 8.58x58 AF2 AF2
H8 304 Q 8.59x59 AF2 AF2
C-term 305 C - AF2 AF2
C-term 306 W - AF2 AF2
C-term 307 R - AF2 AF2
C-term 308 P - AF2 AF2
C-term 309 G - AF2 AF2
C-term 310 V - AF2 AF2
C-term 311 G - AF2 AF2
C-term 312 V - AF2 AF2
C-term 313 Q - AF2 AF2
C-term 314 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 139 34x52 G.H5 N 370 G.H5.19
Van-der-waals ICL2 L 139 34x52 G.H5 N 370 G.H5.19
Hydrophobic TM6 L 232 6x34 G.H5 L 371 G.H5.20
Van-der-waals TM6 L 232 6x34 G.H5 L 371 G.H5.20
Hydrophobic ICL3 M 223 - G.S6 L 342 G.S6.01
Van-der-waals ICL3 M 223 - G.S6 L 342 G.S6.01
Hydrophobic H8 R 293 8x48 G.H5 K 372 G.H5.21
Hydrophobic TM3 I 134 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 134 3x54 G.H5 L 371 G.H5.20
Polar H8 S 292 8x47 G.H5 M 375 G.H5.24
Hydrophobic H8 S 292 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 S 292 8x47 G.H5 M 375 G.H5.24
Hydrophobic TM2 Y 69 2x40 G.H5 M 375 G.H5.24
Van-der-waals TM2 Y 69 2x40 G.H5 M 375 G.H5.24
Hydrophobic ICL2 K 138 34x51 G.HN K 42 G.HN.51
Van-der-waals ICL2 K 138 34x51 G.HN K 42 G.HN.51
Hydrophobic TM5 V 216 5x65 G.H5 L 367 G.H5.16
Polar ICL2 K 138 34x51 G.H5 N 370 G.H5.19
Van-der-waals ICL2 K 138 34x51 G.H5 N 370 G.H5.19
Hydrophobic ICL2 V 137 34x50 G.HN K 42 G.HN.51
Van-der-waals ICL2 V 137 34x50 G.HN K 42 G.HN.51
Polar ICL2 Y 140 34x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 Y 140 34x53 G.H5 N 370 G.H5.19
Van-der-waals ICL2 Y 140 34x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 K 138 34x51 G.HN L 38 G.HN.47
Van-der-waals ICL2 K 138 34x51 G.HN L 38 G.HN.47
Hydrophobic TM5 I 212 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM5 I 212 5x61 G.H5 L 376 G.H5.25
Hydrophobic TM5 Y 209 5x58 G.H5 L 376 G.H5.25
Hydrophobic TM6 V 235 6x37 G.H5 Q 377 G.H5.26
Van-der-waals TM6 V 235 6x37 G.H5 Q 377 G.H5.26
Hydrophobic ICL3 M 223 - G.H4 R 331 G.H4.16
Polar ICL2 V 137 34x50 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 V 137 34x50 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 V 137 34x50 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 Y 140 34x53 G.H5 L 374 G.H5.23
Van-der-waals ICL2 Y 140 34x53 G.H5 L 374 G.H5.23
Hydrophobic ICL2 V 137 34x50 G.S3 V 216 G.S3.01
Hydrophobic ICL2 L 139 34x52 G.H5 I 366 G.H5.15
Hydrophobic TM3 A 133 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 L 374 G.H5.23
Hydrophobic ICL3 M 223 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 M 223 - G.S6 Y 343 G.S6.02
Hydrophobic TM2 M 68 2x39 G.H5 M 375 G.H5.24
Hydrophobic TM5 V 216 5x65 G.H5 L 371 G.H5.20
Polar TM3 A 133 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 I 134 3x54 G.H5 L 374 G.H5.23
Polar TM6 A 224 6x26 G.H5 H 368 G.H5.17
Hydrophobic TM6 A 224 6x26 G.H5 H 368 G.H5.17
Van-der-waals TM6 A 224 6x26 G.H5 H 368 G.H5.17
Hydrophobic ICL2 V 137 34x50 G.HN T 43 G.HN.52
Van-der-waals ICL2 V 137 34x50 G.HN T 43 G.HN.52
Hydrophobic ICL2 Y 140 34x53 G.H5 Q 373 G.H5.22
Van-der-waals ICL2 Y 140 34x53 G.H5 Q 373 G.H5.22
Hydrophobic TM6 T 228 6x30 G.H5 L 371 G.H5.20
Van-der-waals TM6 T 228 6x30 G.H5 L 371 G.H5.20
Polar TM6 T 228 6x30 G.H5 Q 377 G.H5.26
Van-der-waals TM6 T 228 6x30 G.H5 Q 377 G.H5.26
Hydrophobic TM3 I 134 3x54 G.H5 L 376 G.H5.25
Hydrophobic ICL2 K 138 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM6 A 224 6x26 G.H5 D 364 G.H5.13
Van-der-waals TM6 A 224 6x26 G.H5 D 364 G.H5.13
Hydrophobic TM2 M 68 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 M 68 2x39 G.H5 L 374 G.H5.23
Hydrophobic TM2 L 72 2x43 G.H5 M 375 G.H5.24
Polar TM2 S 66 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 S 66 2x37 G.H5 Q 373 G.H5.22
Van-der-waals TM2 S 66 2x37 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 L 139 34x52 G.H5 D 369 G.H5.18
Van-der-waals ICL2 L 139 34x52 G.H5 D 369 G.H5.18
Hydrophobic TM5 S 219 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 S 219 5x68 G.H5 L 367 G.H5.16
Hydrophobic H8 L 295 8x50 G.H5 M 375 G.H5.24
Hydrophobic ICL3 M 223 - G.h4s6 P 341 G.h4s6.20
Hydrophobic TM6 T 228 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 T 228 6x30 G.H5 H 368 G.H5.17
Polar ICL3 A 221 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 A 221 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 A 221 - G.H5 D 364 G.H5.13
Polar TM3 K 136 3x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 139 34x52 G.HN K 42 G.HN.51
Van-der-waals ICL2 L 139 34x52 G.HN K 42 G.HN.51
Polar TM3 R 130 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 L 376 G.H5.25
Hydrophobic ICL2 K 138 34x51 G.HN S 39 G.HN.48
Van-der-waals ICL2 K 138 34x51 G.HN S 39 G.HN.48
Hydrophobic TM7 R 291 7x56 G.H5 M 375 G.H5.24
Van-der-waals TM7 R 291 7x56 G.H5 M 375 G.H5.24