Refined structure (7XMT) of Gi1 - SST4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 224 from structure (63.3%), 130 from model (36.7%)
Residue sidechains - 196 from structure (55.4%), 158 from model (44.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure AF2
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure AF2
G.s4h3 237 D G.s4h3.11 Structure AF2
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure AF2
G.s4h3 240 M G.s4h3.14 Structure AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure AF2
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 264 from structure (78.3%), 73 from model (21.7%)
Residue sidechains - 236 from structure (70.0%), 101 from model (30.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 E - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 W - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 N - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 E - AF2 AF2
N-term 34 E - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 V - AF2 AF2
N-term 37 A - AF2 AF2
N-term 38 G - AF2 AF2
N-term 39 P - AF2 AF2
N-term 40 G - AF2 AF2
N-term 41 D - AF2 AF2
N-term 42 A - AF2 AF2
N-term 43 R - AF2 AF2
TM1 44 A 1.29x29 AF2 AF2
TM1 45 A 1.30x30 AF2 AF2
TM1 46 G 1.31x31 AF2 AF2
TM1 47 M 1.32x32 Structure AF2
TM1 48 V 1.33x33 Structure Structure
TM1 49 A 1.34x34 Structure Structure
TM1 50 I 1.35x35 Structure Structure
TM1 51 Q 1.36x36 Structure AF2
TM1 52 C 1.37x37 Structure Structure
TM1 53 I 1.38x38 Structure Structure
TM1 54 Y 1.39x39 Structure Structure
TM1 55 A 1.40x40 Structure Structure
TM1 56 L 1.41x41 Structure AF2
TM1 57 V 1.42x42 Structure Structure
TM1 58 C 1.43x43 Structure Structure
TM1 59 L 1.44x44 Structure AF2
TM1 60 V 1.45x45 Structure AF2
TM1 61 G 1.46x46 Structure Structure
TM1 62 L 1.47x47 Structure AF2
TM1 63 V 1.48x48 Structure Structure
TM1 64 G 1.49x49 Structure Structure
TM1 65 N 1.50x50 Structure Structure
TM1 66 A 1.51x51 Structure Structure
TM1 67 L 1.52x52 Structure AF2
TM1 68 V 1.53x53 Structure Structure
TM1 69 I 1.54x54 Structure Structure
TM1 70 F 1.55x55 Structure AF2
TM1 71 V 1.56x56 Structure Structure
TM1 72 I 1.57x57 Structure Structure
TM1 73 L 1.58x58 Structure Structure
TM1 74 R 1.59x59 Structure AF2
TM1 75 Y 1.60x60 Structure AF2
ICL1 76 A 12.48x48 Structure Structure
ICL1 77 K 12.49x49 Structure AF2
ICL1 78 M 12.50x50 Structure AF2
ICL1 79 K 12.51x51 Structure AF2
TM2 80 T 2.37x37 Structure Structure
TM2 81 A 2.38x38 Structure Structure
TM2 82 T 2.39x39 Structure Structure
TM2 83 N 2.40x40 Structure Structure
TM2 84 I 2.41x41 Structure Structure
TM2 85 Y 2.42x42 Structure Structure
TM2 86 L 2.43x43 Structure Structure
TM2 87 L 2.44x44 Structure Structure
TM2 88 N 2.45x45 Structure Structure
TM2 89 L 2.46x46 Structure Structure
TM2 90 A 2.47x47 Structure Structure
TM2 91 V 2.48x48 Structure Structure
TM2 92 A 2.49x49 Structure Structure
TM2 93 D 2.50x50 Structure AF2
TM2 94 E 2.51x51 Structure Structure
TM2 95 L 2.52x52 Structure Structure
TM2 96 F 2.53x53 Structure Structure
TM2 97 M 2.54x54 Structure Structure
TM2 98 L 2.55x55 Structure Structure
TM2 99 S 2.56x56 Structure Structure
TM2 100 V 2.57x57 Structure Structure
TM2 101 P 2.58x58 Structure Structure
TM2 102 F 2.59x59 Structure Structure
TM2 103 V 2.60x60 Structure Structure
TM2 104 A 2.61x61 Structure Structure
TM2 105 S 2.62x62 Structure Structure
TM2 106 S 2.63x63 Structure Structure
TM2 107 A 2.64x64 Structure Structure
TM2 108 A 2.65x65 Structure Structure
TM2 109 L 2.66x66 Structure Structure
ECL1 110 R - Structure Structure
ECL1 111 H 23.49x49 Structure Structure
ECL1 112 W 23.50x50 Structure Structure
ECL1 113 P 23.51x51 Structure Structure
ECL1 114 F 23.52x52 Structure Structure
TM3 115 G 3.21x21 Structure Structure
TM3 116 S 3.22x22 Structure Structure
TM3 117 V 3.23x23 Structure Structure
TM3 118 L 3.24x24 Structure Structure
TM3 119 C 3.25x25 Structure Structure
TM3 120 R 3.26x26 Structure AF2
TM3 121 A 3.27x27 Structure Structure
TM3 122 V 3.28x28 Structure Structure
TM3 123 L 3.29x29 Structure Structure
TM3 124 S 3.30x30 Structure Structure
TM3 125 V 3.31x31 Structure Structure
TM3 126 D 3.32x32 Structure Structure
TM3 127 G 3.33x33 Structure Structure
TM3 128 L 3.34x34 Structure Structure
TM3 129 N 3.35x35 Structure Structure
TM3 130 M 3.36x36 Structure Structure
TM3 131 F 3.37x37 Structure Structure
TM3 132 T 3.38x38 Structure Structure
TM3 133 S 3.39x39 Structure Structure
TM3 134 V 3.40x40 Structure Structure
TM3 135 F 3.41x41 Structure Structure
TM3 136 C 3.42x42 Structure Structure
TM3 137 L 3.43x43 Structure Structure
TM3 138 T 3.44x44 Structure Structure
TM3 139 V 3.45x45 Structure Structure
TM3 140 L 3.46x46 Structure Structure
TM3 141 S 3.47x47 Structure Structure
TM3 142 V 3.48x48 Structure Structure
TM3 143 D 3.49x49 Structure Structure
TM3 144 R 3.50x50 Structure Structure
TM3 145 Y 3.51x51 Structure Structure
TM3 146 V 3.52x52 Structure Structure
TM3 147 A 3.53x53 Structure Structure
TM3 148 V 3.54x54 Structure Structure
TM3 149 V 3.55x55 Structure Structure
TM3 150 H 3.56x56 Structure Structure
ICL2 151 P 34.50x50 Structure Structure
ICL2 152 L 34.51x51 Structure Structure
ICL2 153 R 34.52x52 Structure Structure
ICL2 154 A 34.53x53 Structure Structure
ICL2 155 A 34.54x54 Structure Structure
ICL2 156 T 34.55x55 Structure Structure
ICL2 157 Y 34.56x56 Structure Structure
ICL2 158 R 34.57x57 Structure Structure
TM4 159 R 4.38x38 Structure Structure
TM4 160 P 4.39x39 Structure Structure
TM4 161 S 4.40x40 Structure Structure
TM4 162 V 4.41x41 Structure Structure
TM4 163 A 4.42x42 Structure Structure
TM4 164 K 4.43x43 Structure Structure
TM4 165 L 4.44x44 Structure Structure
TM4 166 I 4.45x45 Structure Structure
TM4 167 N 4.46x46 Structure Structure
TM4 168 L 4.47x47 Structure Structure
TM4 169 G 4.48x48 Structure Structure
TM4 170 V 4.49x49 Structure Structure
TM4 171 W 4.50x50 Structure Structure
TM4 172 L 4.51x51 Structure Structure
TM4 173 A 4.52x52 Structure Structure
TM4 174 S 4.53x53 Structure Structure
TM4 175 L 4.54x54 Structure Structure
TM4 176 L 4.55x55 Structure Structure
TM4 177 V 4.56x56 Structure AF2
TM4 178 T 4.57x57 Structure Structure
TM4 179 L 4.58x59 Structure Structure
TM4 180 P 4.59x60 Structure Structure
TM4 181 I 4.60x61 Structure Structure
TM4 182 A 4.61x62 Structure Structure
TM4 183 I 4.62x63 Structure Structure
TM4 184 F 4.63x64 Structure Structure
TM4 185 A 4.64x65 Structure Structure
ECL2 186 D - Structure AF2
ECL2 187 T - Structure Structure
ECL2 188 R - Structure Structure
ECL2 189 P - Structure Structure
ECL2 190 A - AF2 AF2
ECL2 191 R - AF2 AF2
ECL2 192 G - AF2 AF2
ECL2 193 G - AF2 AF2
ECL2 194 Q - AF2 AF2
ECL2 195 A - AF2 AF2
ECL2 196 V - AF2 AF2
ECL2 197 A - Structure Structure
ECL2 198 C 45.50x50 Structure Structure
ECL2 199 N 45.51x51 Structure Structure
ECL2 200 L 45.52x52 Structure Structure
ECL2 201 Q - Structure Structure
ECL2 202 W - Structure Structure
ECL2 203 P - Structure Structure
TM5 204 H 5.31x32 Structure AF2
TM5 205 P 5.32x33 Structure Structure
TM5 206 A 5.33x34 Structure Structure
TM5 207 W 5.34x35 Structure AF2
TM5 208 S 5.35x36 Structure Structure
TM5 209 A 5.36x37 Structure Structure
TM5 210 V 5.37x38 Structure Structure
TM5 211 F 5.38x39 Structure Structure
TM5 212 V 5.39x40 Structure Structure
TM5 213 V 5.40x41 Structure Structure
TM5 214 Y 5.41x42 Structure Structure
TM5 215 T 5.42x43 Structure Structure
TM5 216 F 5.43x44 Structure Structure
TM5 217 L 5.44x45 Structure Structure
TM5 218 L 5.45x46 Structure Structure
TM5 219 G 5.46x461 Structure Structure
TM5 220 F 5.47x47 Structure Structure
TM5 221 L 5.48x48 Structure Structure
TM5 222 L 5.49x49 Structure Structure
TM5 223 P 5.50x50 Structure Structure
TM5 224 V 5.51x51 Structure Structure
TM5 225 L 5.52x52 Structure Structure
TM5 226 A 5.53x53 Structure Structure
TM5 227 I 5.54x54 Structure Structure
TM5 228 G 5.55x55 Structure Structure
TM5 229 L 5.56x56 Structure Structure
TM5 230 C 5.57x57 Structure Structure
TM5 231 Y 5.58x58 Structure Structure
TM5 232 L 5.59x59 Structure Structure
TM5 233 L 5.60x60 Structure Structure
TM5 234 I 5.61x61 Structure Structure
TM5 235 V 5.62x62 Structure Structure
TM5 236 G 5.63x63 Structure Structure
TM5 237 K 5.64x64 Structure Structure
TM5 238 M 5.65x65 Structure Structure
TM5 239 R 5.66x66 Structure Structure
TM5 240 A 5.67x67 Structure Structure
TM5 241 V 5.68x68 Structure Structure
ICL3 242 A - Structure Structure
ICL3 243 L - Structure Structure
ICL3 244 R - Structure Structure
ICL3 245 A - Structure Structure
ICL3 246 G - Structure Structure
TM6 247 W 6.23x23 Structure Structure
TM6 248 Q 6.24x24 Structure Structure
TM6 249 Q 6.25x25 Structure AF2
TM6 250 R 6.26x26 Structure Structure
TM6 251 R 6.27x27 Structure AF2
TM6 252 R 6.28x28 Structure Structure
TM6 253 S 6.29x29 Structure Structure
TM6 254 E 6.30x30 Structure Structure
TM6 255 K 6.31x31 Structure Structure
TM6 256 K 6.32x32 Structure Structure
TM6 257 I 6.33x33 Structure Structure
TM6 258 T 6.34x34 Structure Structure
TM6 259 R 6.35x35 Structure Structure
TM6 260 L 6.36x36 Structure Structure
TM6 261 V 6.37x37 Structure Structure
TM6 262 L 6.38x38 Structure Structure
TM6 263 M 6.39x39 Structure Structure
TM6 264 V 6.40x40 Structure AF2
TM6 265 V 6.41x41 Structure Structure
TM6 266 V 6.42x42 Structure Structure
TM6 267 V 6.43x43 Structure Structure
TM6 268 F 6.44x44 Structure Structure
TM6 269 V 6.45x45 Structure Structure
TM6 270 L 6.46x46 Structure Structure
TM6 271 C 6.47x47 Structure Structure
TM6 272 W 6.48x48 Structure Structure
TM6 273 M 6.49x49 Structure AF2
TM6 274 P 6.50x50 Structure Structure
TM6 275 F 6.51x51 Structure Structure
TM6 276 Y 6.52x52 Structure Structure
TM6 277 V 6.53x53 Structure Structure
TM6 278 V 6.54x54 Structure Structure
TM6 279 Q 6.55x55 Structure Structure
TM6 280 L 6.56x56 Structure Structure
TM6 281 L 6.57x57 Structure Structure
TM6 282 N 6.58x58 Structure Structure
TM6 283 L 6.59x59 Structure Structure
TM6 284 F 6.60x60 Structure AF2
TM6 285 V 6.61x61 AF2 AF2
ECL3 286 T - AF2 AF2
ECL3 287 S - AF2 AF2
ECL3 288 L - Structure Structure
ECL3 289 D - Structure Structure
TM7 290 A 7.32x31 Structure Structure
TM7 291 T 7.33x32 Structure Structure
TM7 292 V 7.34x33 Structure Structure
TM7 293 N 7.35x34 Structure Structure
TM7 294 H 7.36x35 Structure AF2
TM7 295 V 7.37x36 Structure Structure
TM7 296 S 7.38x37 Structure Structure
TM7 297 L 7.39x38 Structure Structure
TM7 298 I 7.40x39 Structure AF2
TM7 299 L 7.41x40 Structure Structure
TM7 300 S 7.42x41 Structure Structure
TM7 301 Y 7.43x42 Structure Structure
TM7 302 A 7.44x43 Structure Structure
TM7 303 N 7.45x45 Structure Structure
TM7 304 S 7.46x46 Structure Structure
TM7 305 C 7.47x47 Structure Structure
TM7 306 A 7.48x48 Structure Structure
TM7 307 N 7.49x49 Structure Structure
TM7 308 P 7.50x50 Structure Structure
TM7 309 I 7.51x51 Structure Structure
TM7 310 L 7.52x52 Structure Structure
TM7 311 Y 7.53x53 Structure Structure
TM7 312 G 7.54x54 Structure Structure
TM7 313 F 7.55x55 Structure AF2
TM7 314 L 7.56x56 Structure Structure
H8 315 S 8.47x47 Structure Structure
H8 316 D 8.48x48 Structure Structure
H8 317 N 8.49x49 Structure Structure
H8 318 F 8.50x50 Structure AF2
H8 319 R 8.51x51 Structure Structure
H8 320 R 8.52x52 Structure Structure
H8 321 F 8.53x53 AF2 AF2
H8 322 F 8.54x54 AF2 AF2
H8 323 Q 8.55x55 AF2 AF2
H8 324 R 8.56x56 AF2 AF2
H8 325 V 8.57x57 AF2 AF2
H8 326 L 8.58x58 AF2 AF2
H8 327 C 8.59x59 AF2 AF2
C-term 328 L - AF2 AF2
C-term 329 R - AF2 AF2
C-term 330 C - AF2 AF2
C-term 331 C - AF2 AF2
C-term 332 L - AF2 AF2
C-term 333 L - AF2 AF2
C-term 334 E - AF2 AF2
C-term 335 G - AF2 AF2
C-term 336 A - AF2 AF2
C-term 337 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 155 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 155 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 R 251 6x27 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 S 253 6x29 G.H5 F 354 G.H5.26
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 152 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic H8 S 315 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 315 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 N 317 8x49 G.H5 G 352 G.H5.24
Polar H8 N 317 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 317 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 241 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL3 R 244 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 244 - G.H5 D 337 G.H5.09
Van-der-waals ICL2 P 151 34x50 G.H5 N 347 G.H5.19
Polar H8 D 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 D 316 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 D 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL3 A 245 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 V 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 82 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 238 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 148 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 241 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 260 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 260 6x36 G.H5 L 353 G.H5.25
Polar H8 N 317 8x49 G.H5 F 354 G.H5.26
Ionic TM4 R 159 4x38 G.HN E 28 G.HN.52
Polar TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 159 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 159 4x38 G.HN E 28 G.HN.52
Polar TM6 S 253 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 253 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 257 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 257 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 238 5x65 G.H5 K 345 G.H5.17
Van-der-waals TM5 M 238 5x65 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 257 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 257 6x33 G.H5 F 354 G.H5.26
Polar ICL2 R 158 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 158 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 158 34x57 G.H5 D 350 G.H5.22
Polar H8 S 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 315 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 A 245 - G.H5 D 337 G.H5.09
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 148 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 W 247 6x23 G.S6 Y 320 G.S6.02
Polar TM6 W 247 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 W 247 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 W 247 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 257 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 241 5x68 G.H5 I 344 G.H5.16
Polar TM2 T 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 82 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 82 2x39 G.H5 D 350 G.H5.22