SST4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Aug. 3, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

J-2156 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

CST-17, SRIF-28, cortistatin-14, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL4 S 315 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 S 315 - G.H5 F 354 G.H5.26
Hydrophobic TM2 T 82 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 245 5x72 G.S6 Y 320 G.S6.02
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 238 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 238 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 158 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 158 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 158 - G.H5 D 350 G.H5.22
Hydrophobic TM6 I 257 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 257 6x33 G.H5 L 353 G.H5.25
Polar H8 N 317 8x49 G.H5 F 354 G.H5.26
Van-der-waals ICL2 P 151 - G.H5 N 347 G.H5.19
Hydrophobic TM5 M 238 5x65 G.H5 K 345 G.H5.17
Van-der-waals TM5 M 238 5x65 G.H5 K 345 G.H5.17
Hydrophobic TM5 A 245 5x72 G.H5 D 337 G.H5.09
Polar TM6 S 253 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 253 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 260 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 260 6x36 G.H5 L 353 G.H5.25
Polar ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 A 155 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 155 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 152 - G.hns1 R 32 G.hns1.03
Polar H8 D 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 D 316 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 D 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 F 264 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 257 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 241 5x68 G.H5 I 344 G.H5.16
Ionic TM4 R 159 4x38 G.HN E 28 G.HN.52
Polar TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 159 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic H8 N 317 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM5 R 244 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 244 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 V 148 3x54 G.H5 C 351 G.H5.23
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 257 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 257 6x33 G.H5 F 354 G.H5.26
Polar H8 N 317 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 317 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 148 3x54 G.H5 N 347 G.H5.19
Polar ICL4 S 315 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 315 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 315 - G.H5 G 352 G.H5.24
Hydrophobic TM6 S 253 6x29 G.H5 F 354 G.H5.26
Polar TM2 T 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 82 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 W 247 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 241 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 241 5x68 G.H5 T 340 G.H5.12