5-HT2B receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SRR

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.NEURON.2022.08.006

PUBLICATION DATE

Sept. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

Lysergide - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 N 164 - G.H5 N 239 G.H5.19
Hydrophobic TM3 I 157 3x54 G.H5 L 240 G.H5.20
Polar TM2 T 89 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM6 N 318 6x29 G.H5 L 240 G.H5.20
Hydrophobic TM6 L 326 6x37 G.H5 L 245 G.H5.25
Hydrophobic ICL2 I 161 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 P 160 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 P 160 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 I 161 - G.S3 V 79 G.S3.01
Hydrophobic TM5 L 244 5x65 G.H5 L 240 G.H5.20
Polar ICL2 N 164 - G.hns1 R 31 G.hns1.02
Polar ICL2 Q 165 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 Q 165 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 E 319 6x30 G.H5 L 240 G.H5.20
Hydrophobic ICL4 F 383 - G.H5 V 246 G.H5.26
Van-der-waals ICL4 F 383 - G.H5 V 246 G.H5.26
Hydrophobic TM3 A 156 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 156 3x53 G.H5 Y 243 G.H5.23
Polar H8 N 384 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 N 384 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 N 384 8x47 G.H5 N 244 G.H5.24
Polar TM3 A 156 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 156 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM2 T 89 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 153 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM3 D 152 3x49 G.H5 Y 243 G.H5.23
Polar TM2 Y 87 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM2 Y 87 2x37 G.H5 E 242 G.H5.22
Van-der-waals TM2 Y 87 2x37 G.H5 E 242 G.H5.22
Polar ICL2 P 160 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 160 - G.H5 N 239 G.H5.19
Polar TM2 N 90 2x40 G.H5 N 244 G.H5.24
Van-der-waals TM2 N 90 2x40 G.H5 N 244 G.H5.24
Hydrophobic ICL2 I 161 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 I 161 - G.H5 F 228 G.H5.08
Hydrophobic TM6 N 318 6x29 G.H5 V 246 G.H5.26
Hydrophobic TM6 E 319 6x30 G.H5 L 236 G.H5.16
Hydrophobic ICL2 P 160 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 160 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 I 161 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 161 - G.H5 I 235 G.H5.15
Polar ICL2 Q 165 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 165 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 165 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 322 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 V 325 6x36 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 160 - G.H5 L 236 G.H5.16
Hydrophobic H8 F 387 8x50 G.H5 N 244 G.H5.24
Polar ICL2 N 167 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 N 164 - G.H5 I 235 G.H5.15
Polar TM3 R 153 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 153 3x50 G.H5 Y 243 G.H5.23