C5a1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7Y65

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-023-00779-2

PUBLICATION DATE

March 1, 2023

3D VIEW

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LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

C5a - Agonist

PHYSIOLOGICAL LIGANDS

C5a des-Arg, C5a, ribosomal protein S19, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 T 235 - G.H5 F 354 G.H5.26
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Polar ICL2 N 146 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 146 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 I 225 5x61 G.H5 L 353 G.H5.25
Polar ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Polar TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 N 71 2x39 G.H5 C 351 G.H5.23
Polar TM6 K 239 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 239 6x32 G.H5 G 352 G.H5.24
Polar TM6 K 239 6x32 G.H5 L 353 G.H5.25
Polar ICL2 Q 145 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 145 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 K 239 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 141 - G.H5 I 343 G.H5.15
Hydrophobic TM3 L 137 3x53 G.H5 C 351 G.H5.23
Polar ICL3 S 237 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 S 237 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 S 237 - G.H5 F 354 G.H5.26
Ionic ICL3 R 232 - G.H5 D 341 G.H5.13
Polar ICL3 R 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 232 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 235 - G.H5 I 344 G.H5.16
Polar ICL2 R 148 - G.hns1 R 32 G.hns1.03
Polar ICL2 N 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 141 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 A 234 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 A 234 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 142 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 V 244 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 141 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 142 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 142 - G.H5 F 336 G.H5.08
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 235 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 A 234 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 A 234 - G.H5 K 345 G.H5.17
Hydrophobic TM5 T 229 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 T 235 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 T 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 Q 145 - G.H5 I 343 G.H5.15