C5a1 receptor (c5ar1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a1 receptor
GENE
C5AR1 (C5AR, C5R1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
S
|
F
|
N
|
Y
|
T
|
T
|
P
|
D
|
10 |
Y
|
G
|
H
|
Y
|
D
|
D
|
K
|
D
|
T
|
L
|
20 |
D
|
L
|
N
|
T
|
P
|
V
|
D
|
K
|
T
|
S
|
30 |
TM1 | |||||||||
N
|
T
|
L
|
R
|
V
|
P
|
D
|
I
|
L
|
A
|
40 |
L
|
V
|
I
|
F
|
A
|
V
|
V
|
F
|
L
|
V
|
50 |
G
|
V
|
L
|
G
|
N
|
A
|
L
|
V
|
V
|
W
|
60 |
ICL1 | |||||||||
V
|
T
|
A
|
F
|
E
|
A
|
K
|
R
|
T
|
I
|
70 |
TM2 | |||||||||
N
|
A
|
I
|
W
|
F
|
L
|
N
|
L
|
A
|
V
|
80 |
A
|
D
|
F
|
L
|
S
|
C
|
L
|
A
|
L
|
P
|
90 |
I
|
L
|
F
|
T
|
S
|
I
|
V
|
Q
|
H
|
H
|
100 |
ECL1 | TM3 | ||||||||
H
|
W
|
P
|
F
|
G
|
G
|
A
|
A
|
C
|
S
|
110 |
I
|
L
|
P
|
S
|
L
|
I
|
L
|
L
|
N
|
M
|
120 |
Y
|
A
|
S
|
I
|
L
|
L
|
L
|
A
|
T
|
I
|
130 |
S
|
A
|
D
|
R
|
F
|
L
|
L
|
V
|
F
|
K
|
140 |
ICL2 | |||||||||
P
|
I
|
W
|
C
|
Q
|
N
|
F
|
R
|
G
|
A
|
150 |
TM4 | |||||||||
G
|
L
|
A
|
W
|
I
|
A
|
C
|
A
|
V
|
A
|
160 |
W
|
G
|
L
|
A
|
L
|
L
|
L
|
T
|
I
|
P
|
170 |
ECL2 | |||||||||
S
|
F
|
L
|
Y
|
R
|
V
|
V
|
R
|
E
|
E
|
180 |
Y
|
F
|
P
|
P
|
K
|
V
|
L
|
C
|
G
|
V
|
190 |
TM5 | |||||||||
D
|
Y
|
S
|
H
|
D
|
K
|
R
|
R
|
E
|
R
|
200 |
A
|
V
|
A
|
I
|
V
|
R
|
L
|
V
|
L
|
G
|
210 |
F
|
L
|
W
|
P
|
L
|
L
|
T
|
L
|
T
|
I
|
220 |
C
|
Y
|
T
|
F
|
I
|
L
|
L
|
R
|
T
|
W
|
230 |
ICL3 | TM6 | ||||||||
S
|
R
|
R
|
A
|
T
|
R
|
S
|
T
|
K
|
T
|
240 |
L
|
K
|
V
|
V
|
V
|
A
|
V
|
V
|
A
|
S
|
250 |
F
|
F
|
I
|
F
|
W
|
L
|
P
|
Y
|
Q
|
V
|
260 |
T
|
G
|
I
|
M
|
M
|
S
|
F
|
L
|
E
|
P
|
270 |
ECL3 | TM7 | ||||||||
S
|
S
|
P
|
T
|
F
|
L
|
L
|
L
|
K
|
K
|
280 |
L
|
D
|
S
|
L
|
C
|
V
|
S
|
F
|
A
|
Y
|
290 |
I
|
N
|
C
|
C
|
I
|
N
|
P
|
I
|
I
|
Y
|
300 |
H8 | |||||||||
V
|
V
|
A
|
G
|
Q
|
G
|
F
|
Q
|
G
|
R
|
310 |
C-term | |||||||||
L
|
R
|
K
|
S
|
L
|
P
|
S
|
L
|
L
|
R
|
320 |
N
|
V
|
L
|
T
|
E
|
E
|
S
|
V
|
V
|
R
|
330 |
E
|
S
|
K
|
S
|
F
|
T
|
R
|
S
|
T
|
V
|
340 |
D
|
T
|
M
|
A
|
Q
|
K
|
T
|
Q
|
A
|
V
|
350 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
C5a des-Arg, C5a, ribosomal protein S19, C3a