C5a1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HK5

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41589-023-01339-W

PUBLICATION DATE

May 10, 2023

3D VIEW

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LIGAND INTERACTIONS

110 interactions (Click to see)

LIGANDS

C5a - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

C5a des-Arg, ribosomal protein S19, C5a, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 142 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 F 147 34x56 G.hns1 R 32 G.hns1.03
Polar ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 N 146 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 146 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL3 T 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 235 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 T 235 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 237 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 S 237 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 142 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 K 239 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 239 6x32 G.H5 L 353 G.H5.25
Polar ICL2 C 144 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 236 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 236 - G.H5 F 354 G.H5.26
Polar TM3 L 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 244 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 T 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 T 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 A 234 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 Q 145 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM3 L 137 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 137 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 T 229 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 A 234 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 A 234 - G.H5 K 345 G.H5.17
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Polar ICL2 R 148 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 148 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 148 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 A 234 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03
Polar ICL3 R 233 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 233 - G.h4s6 K 314 G.h4s6.08
Polar TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 234 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 A 234 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 235 - G.H5 I 344 G.H5.16
Hydrophobic TM6 K 239 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 243 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 I 142 34x51 G.H5 I 343 G.H5.15
Polar ICL2 Q 145 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 145 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 141 34x50 G.H5 T 340 G.H5.12
Van-der-waals TM6 K 239 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 I 142 34x51 G.H5 F 336 G.H5.08
Ionic ICL3 R 232 - G.H5 D 341 G.H5.13
Polar ICL3 R 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 232 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 232 - G.H5 D 341 G.H5.13