5-HT1F receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Aug. 4, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 L 211 5x68 G.H5 D 341 G.H5.13
Polar TM6 K 290 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 290 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 290 6x32 G.H5 F 354 G.H5.26
Ionic H8 E 352 8x48 G.H5 K 349 G.H5.21
Polar H8 E 352 8x48 G.H5 K 349 G.H5.21
Polar TM7 F 350 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 350 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 350 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 204 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 211 5x68 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 211 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 208 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 208 5x65 G.H5 L 353 G.H5.25
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 125 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 211 5x68 G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 129 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 V 129 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 129 34x51 G.S3 L 194 G.S3.01
Polar TM6 K 290 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 290 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 125 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 125 3x54 G.H5 N 347 G.H5.19
Aromatic TM6 R 287 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 287 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 287 6x29 G.H5 F 354 G.H5.26
Polar H8 N 351 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 351 8x47 G.H5 D 350 G.H5.22
Polar TM6 R 287 6x29 G.h4s6 D 315 G.h4s6.09
Polar ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 211 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 204 5x61 G.H5 L 348 G.H5.20
Polar TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 294 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 A 291 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 291 6x33 G.H5 L 353 G.H5.25