Structure information

5-HT1F receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EXD

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00527-4

PUBLICATION DATE

Aug. 4, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lasmiditan D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lasmiditan I104 3.33x33 TM3 Van der Waals
lasmiditan I104 3.33x33 TM3 hydrophobic
lasmiditan C107 3.36x36 TM3 Van der Waals
lasmiditan C107 3.36x36 TM3 polar (hydrogen bond)
lasmiditan T108 3.37x37 TM3 Van der Waals
lasmiditan I174 45.52x52 ECL2 Van der Waals
lasmiditan I174 45.52x52 ECL2 hydrophobic
lasmiditan H176 ECL2 polar (hydrogen bond with backbone)
lasmiditan H176 ECL2 Van der Waals
lasmiditan T182 5.39x40 TM5 Van der Waals
lasmiditan S185 5.42x43 TM5 Van der Waals
lasmiditan W306 6.48x48 TM6 hydrophobic
lasmiditan W306 6.48x48 TM6 Van der Waals
lasmiditan F309 6.51x51 TM6 hydrophobic
lasmiditan F309 6.51x51 TM6 Van der Waals
lasmiditan F310 6.52x52 TM6 Van der Waals
lasmiditan F310 6.52x52 TM6 hydrophobic
lasmiditan E313 6.55x55 TM6 polar (charge-assisted hydrogen bond)
lasmiditan N317 6.59x59 TM6 polar (hydrogen bond)
lasmiditan N317 6.59x59 TM6 Van der Waals
lasmiditan Y337 7.43x42 TM7 Van der Waals
lasmiditan Y337 7.43x42 TM7 hydrophobic

Ligands

lasmiditan

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Residue Diagrams

S N I T T T M L A L G S L T L S V L I K 1 C S L A V T D F L V A L V V M P F S I V Y 2 A S L H L I S C T C C T I D V S L W I D 3 A G I M I T I V W I I S V F I S M P P L 4 Y L I L I L A L P I Y F A G F T S Y I T S 5 G L I L G A F V I C W L P F F V K E L V 6 L P N I L S N L Y G L W A L F N S M E 7
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ICL1 R K L H ICL1ECL1 S W I M ECL1ICL2 A V E Y A R K R ICL2ECL2 Q G T S R D D E C I I K H D ECL2ICL3 I A K E E V N G Q V L L E S G E K S T K S V S T S Y V L E K S L S D P S T D F D K I H S T V R S L R S E F K H E K S W R R Q ICL3ECL3 D K C K I ECL3N-term M D F L N S S D Q N L T S E E L L N R N-termC-term V R C R C C-term M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D T P K H A G I M I T I V W I I S V F I S M P P L F W R H H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H K R Q A S R K I S G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F Q K F K K A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1F receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 C107
3x37 3.37x37 T108
ECL2
45x52 45.52x52 I174
TM5
5x40 5.39x40 T182
5x43 5.42x43 S185
TM6
6x48 6.48x48 W306
6x51 6.51x51 F309
6x52 6.52x52 F310
6x55 6.55x55 E313
6x59 6.59x59 N317
TM7
7x42 7.43x42 Y337