GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X8R

RESOLUTION

2.6 Å

REFERENCE

10.1073/PNAS.2200155119

PUBLICATION DATE

June 29, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

46 interactions (Click to see)

LIGANDS

CHEMBL2158411 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37), glucagon



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 331 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 327 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 254 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 254 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 334 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 260 - G.hns1 A 39 G.hns1.03
Polar TM6 R 348 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 348 6x37 G.H5 E 392 G.H5.24
Aromatic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 N 338 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 N 338 5x68 G.H5 R 385 G.H5.17
Polar TM6 R 348 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 348 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 330 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 356 6x45 G.H5 L 393 G.H5.25
Polar TM4 Q 263 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 Q 263 4x40 G.HN Q 35 G.HN.52
Polar TM6 R 348 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM7 Y 402 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Polar H8 N 407 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 406 8x47 G.H5 E 392 G.H5.24
Polar TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 337 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 359 6x48 G.H5 Y 391 G.H5.23
Ionic ICL2 E 262 - G.HN K 34 G.HN.51
Polar ICL2 E 262 - G.HN K 34 G.HN.51
Hydrophobic ICL2 E 262 - G.HN K 34 G.HN.51
Van-der-waals ICL2 E 262 - G.HN K 34 G.HN.51
Hydrophobic TM5 V 331 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 334 5x64 G.H5 L 394 G.H5.26
Van-der-waals TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 257 - G.H5 I 383 G.H5.15
Ionic ICL2 E 262 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 262 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 262 - G.hns1 R 38 G.hns1.02
Polar TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 251 3x54 G.H5 L 393 G.H5.25
Polar TM5 N 338 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 N 338 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 255 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM6 S 352 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 257 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 257 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 E 262 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 262 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 F 260 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 F 260 - G.hns1 R 38 G.hns1.02
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Polar TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 387 G.H5.19
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 384 G.H5.16