GPR88 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 26, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Polar ICL2 Q 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 281 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 281 - G.H5 F 354 G.H5.26
Hydrophobic TM3 L 141 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 Y 212 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 219 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 219 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Polar TM3 L 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 218 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 281 - G.H5 K 345 G.H5.17
Hydrophobic TM5 V 226 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 226 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 V 286 6x37 G.H5 L 353 G.H5.25
Polar TM4 Q 154 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 Q 154 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 154 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL4 R 339 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 142 3x54 G.H5 C 351 G.H5.23
Hydrophobic H8 N 340 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 281 - G.H5 L 348 G.H5.20
Van-der-waals ICL4 R 339 - G.H5 G 352 G.H5.24
Hydrophobic TM5 I 215 5x61 G.H5 L 353 G.H5.25
Polar ICL2 Q 150 34x54 G.HN E 28 G.HN.52
Hydrophobic TM5 V 219 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 S 222 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 222 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 226 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 226 5x72 G.H5 D 341 G.H5.13