FFA2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8T3S

RESOLUTION

3.1 Å

REFERENCE

10.1126/SCIADV.ADJ2384

PUBLICATION DATE

Jan. 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

2 interactions (Click to see)

LIGANDS

butyric acid - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

butyric acid, trans-2-methylcrotonic acid, propanoic acid, acetic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 107 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 107 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 107 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM2 V 44 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 Y 243 G.H5.23
Polar ICL3 Q 215 - G.H5 Q 237 G.H5.17
Hydrophobic ICL3 Q 215 - G.H5 Q 237 G.H5.17
Van-der-waals ICL3 Q 215 - G.H5 Q 237 G.H5.17
Ionic TM6 R 217 6x31 G.H5 D 233 G.H5.13
Polar TM6 R 217 6x31 G.H5 D 233 G.H5.13
Van-der-waals TM6 R 217 6x31 G.H5 D 233 G.H5.13
Hydrophobic TM2 A 42 2x37 G.H5 E 242 G.H5.22
Hydrophobic ICL2 V 115 34x51 G.S1 L 34 G.S1.02
Hydrophobic ICL2 K 118 34x54 G.H5 M 238 G.H5.18
Van-der-waals ICL2 K 118 34x54 G.H5 M 238 G.H5.18
Hydrophobic TM5 Q 209 5x68 G.H5 L 236 G.H5.16
Polar ICL3 Q 215 - G.h4s6 G 207 G.h4s6.11
Hydrophobic ICL3 Q 215 - G.h4s6 G 207 G.h4s6.11
Van-der-waals ICL3 Q 215 - G.h4s6 G 207 G.h4s6.11
Hydrophobic ICL2 V 115 34x51 G.S3 V 79 G.S3.01
Polar TM6 R 217 6x31 G.H5 Q 237 G.H5.17
Hydrophobic TM6 R 217 6x31 G.H5 Q 237 G.H5.17
Van-der-waals TM6 R 217 6x31 G.H5 Q 237 G.H5.17
Hydrophobic TM3 V 111 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 V 111 3x54 G.H5 L 236 G.H5.16
Ionic ICL2 R 121 34x57 G.H5 E 242 G.H5.22
Polar ICL2 R 121 34x57 G.H5 E 242 G.H5.22
Hydrophobic ICL2 R 121 34x57 G.H5 E 242 G.H5.22
Van-der-waals ICL2 R 121 34x57 G.H5 E 242 G.H5.22
Hydrophobic ICL1 Q 40 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 111 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 K 118 34x54 G.H5 I 235 G.H5.15
Van-der-waals ICL2 K 118 34x54 G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 114 34x50 G.H5 L 236 G.H5.16
Van-der-waals ICL2 P 114 34x50 G.H5 L 236 G.H5.16
Hydrophobic ICL2 Y 117 34x53 G.H5 N 239 G.H5.19
Van-der-waals ICL2 Y 117 34x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 V 115 34x51 G.H5 F 228 G.H5.08
Hydrophobic ICL2 K 118 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 K 118 34x54 G.H5 N 239 G.H5.19
Hydrophobic TM3 R 107 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 107 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 119 34x55 G.S1 L 34 G.S1.02
Hydrophobic ICL2 V 115 34x51 G.H5 K 232 G.H5.12
Hydrophobic ICL3 A 214 - G.h4s6 I 210 G.h4s6.20
Van-der-waals ICL3 A 214 - G.h4s6 I 210 G.h4s6.20
Polar C-term S 276 - G.H5 N 244 G.H5.24
Hydrophobic TM5 F 202 5x61 G.H5 L 240 G.H5.20
Polar TM3 G 110 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 G 110 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM6 R 216 6x30 G.H5 V 246 G.H5.26
Polar ICL2 Q 116 34x52 G.s2s3 D 77 G.s2s3.01
Hydrophobic TM6 L 223 6x37 G.H5 L 245 G.H5.25
Hydrophobic TM2 H 45 2x40 G.H5 E 242 G.H5.22
Hydrophobic ICL2 P 114 34x50 G.H5 K 232 G.H5.12
Hydrophobic TM5 M 206 5x65 G.H5 L 240 G.H5.20
Van-der-waals TM5 M 206 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 217 6x31 G.H5 L 240 G.H5.20
Polar ICL2 R 121 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 121 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 121 34x57 G.hns1 R 31 G.hns1.02
Polar ICL2 P 114 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 114 34x50 G.H5 N 239 G.H5.19
Hydrophobic TM5 F 202 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 F 202 5x61 G.H5 L 245 G.H5.25
Polar ICL2 Y 117 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 117 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 Y 117 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 V 115 34x51 G.H5 I 235 G.H5.15
Hydrophobic TM6 R 217 6x31 G.H5 L 236 G.H5.16
Polar ICL2 S 120 34x56 G.hns1 R 32 G.hns1.03
Polar TM3 E 106 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 106 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 E 106 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 114 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 114 34x50 G.H5 I 235 G.H5.15
Hydrophobic ICL2 L 119 34x55 G.S3 V 79 G.S3.01
Hydrophobic TM6 A 220 6x34 G.H5 V 246 G.H5.26
Polar TM7 F 273 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM7 F 273 7x53 G.H5 N 244 G.H5.24
Van-der-waals TM7 F 273 7x53 G.H5 N 244 G.H5.24
Polar TM3 G 110 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 G 110 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 G 110 3x53 G.H5 Y 243 G.H5.23
Polar ICL2 L 119 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 119 34x55 G.hns1 R 31 G.hns1.02