Y1 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 31, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

neuropeptide Y, peptide YY, pancreatic polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Ionic TM5 R 241 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 342 G.H5.13
Ionic TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 E 257 6x29 G.H5 F 355 G.H5.26
Polar TM3 L 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 138 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 141 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 C 352 G.H5.23
Polar TM3 E 137 3x49 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 145 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 145 - G.H5 T 341 G.H5.12
Hydrophobic TM6 M 264 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 264 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 265 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 234 5x61 G.H5 L 354 G.H5.25
Polar ICL2 G 147 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 147 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 349 G.H5.20
Hydrophobic H8 K 325 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 R 146 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 R 146 - G.H5 F 337 G.H5.08
Hydrophobic TM3 I 142 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 I 345 G.H5.16
Hydrophobic H8 N 324 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 C 352 G.H5.23
Polar TM4 N 151 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 M 248 5x75 G.S6 Y 321 G.S6.02
Hydrophobic TM5 L 238 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 145 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 145 - G.H5 I 345 G.H5.16
Polar TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 261 6x33 G.H5 L 354 G.H5.25
Ionic TM6 R 254 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 L 349 G.H5.20
Polar ICL2 P 145 - G.H5 N 348 G.H5.19
Hydrophobic TM5 R 241 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM6 Y 253 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 I 261 6x33 G.H5 F 355 G.H5.26